Area of Specialization: Molecular Biology, Neurobiology, Physiology Academic Qualifications
Ph.D. (Physiology) (2006 – 2012) Faculty of Medicine, University of Toronto, Canada Thesis title: Molecular Mechanisms Involved in Insulin- and Leptin-mediated Regulation of Hypothalamic Proglucagon Gene Expression and the Action of Glucagon-like Peptides on Hypothalamic Neuropeptides M.D. (Physician) (1987 – 1993) Donetsk State Medical Institute/University, Donetsk, Ukraine (former USSR)
Professional Experience
Postdoctoral Research Fellow (2012 – 2013) Department of Physiology, Faculty of Medicine, University of Toronto, Canada Graduate Research Assistant (2006 – 2012) Department of Physiology, Faculty of Medicine, University of Toronto, Canada Research Assistant Professor / Endocrine Pharmacology Instructor (2002 – 2006) Toxicology Laboratory, Department of Biomedical Sciences, College of Veterinary Medicine, Nursing and Allied Health, Tuskegee University, USA Research Associate / Endocrine Pharmacology Instructor (2001 – 2002) Toxicology Laboratory, Department of Biomedical Sciences, College of Veterinary Medicine, Nursing and Allied Health, Tuskegee University, USA General Practitioner / Family Physician (1995 – 2000) Maharashtra Government Rural Hospital at Dodamarg, Ingesh Rural Hospital at Nerur (Kudal), and Rameshwar Clinic at Kasal, District Sindhudurg, Maharashtra, India Clinical Internship / Residency (1993 – 1995) L. T. M. General Hospital and L. T. M. Medical College, Mumbai, India Awards and Fellowships
Postdoctoral Research Fellowship (2012 – 2013) Department of Physiology, Faculty of Medicine, University of Toronto, Canada Postgraduate Scholarship (2009 – 2012) Natural Sciences and Engineering Research Council of Canada, and Ministry of Training, Colleges and Universities, Government of Ontario, Canada Open Fellowship (2006 – 2012) Department of Physiology, Faculty of Medicine, University of Toronto, Canada BBDC-Novo Nordisk Studentship Award (2006 – 2007) Banting and Best Diabetes Centre, Faculty of Medicine, University of Toronto, Canada Research Fellowship (2001 – 2006) NIH-funded projects, Tuskegee University, USA Merit Scholarship (1986 – 1993) Scholarship to study General Medicine at the Donetsk State Medical Institute, Ukraine Certification/Membership The Endocrine Society, U.S.A Medical Council of India
Maharashtra Medical Council Scientific Publications 1. Purser MJ*, Dalvi PS*, Belsham DD (2013) The cytokine ciliary neurotrophic factor
(CNTF) activates hypothalamic urocortin-expressing neurons both in vitro and in vivo. PLoS One 8(4):e61616 (*equal contribution)
2. Dalvi PS, Dalvi RR, Billups LH (2013) Potentiation of the hepatic toxicity of carbon
disulfide by chlordane. Toxicology International 20:132-37
3. Dalvi PS, Erbiceanu FD, Irwin DM, Belsham DD (2012) Direct Regulation of the
Proglucagon Gene by Insulin, Leptin and cAMP in Embryonic versus Adult Hypothalamic Neurons. Molecular Endocrinology 26:1339-55
4. Dalvi PS, Belsham DD (2012) Glucagon-Like Peptide-2 Directly Regulates Hypothalamic
Neurons Expressing Neuropeptides Linked to Appetite Control in Vivo and in Vitro. Endocrinology 153:2385-97 (This article was selected by the Endocrine Society, USA for the ‘Outstanding First Authored Paper in Endocrinology Award’ for the year 2012)
5. Dalvi PS, Nazarians-Armavil A, Purser MJ, Belsham DD (2012) Glucagon-Like Peptide-1
Receptor Agonist, Exendin-4, Regulates Feeding-Associated Neuropeptides in Hypothalamic Neurons in Vivo and in Vitro. Endocrinology 153:2208-22 (This article was selected by the editors of Endocrinology for the commentary in News and Views, Endocrionology, 2012, 153:2051-3)
6. Dalvi PS, Nazarians-Armavil A, Tung S, Belsham DD (2011) Immortalized Neurons for the
Study of Hypothalamic Function. American Journal of Physiology - Regulatory, Integrative and Comparative Physiology 300:R1030-52
7. Belsham DD, Fick LJ, Dalvi PS, Centeno ML, Chalmers JA, Lee PK, Wang Y, Drucker DJ,
Koletar MM (2009) Ciliary neurotrophic factor recruitment of glucagon-like peptide-1 mediates neuro-genesis, allowing immortalization of adult murine hypothalamic neurons. FASEB J 23:4256-65
8. Madadi G, Dalvi PS, Belsham DD (2008) Regulation of brain insulin mRNA by glucose
and glucagon-like peptide 1. Biochem Biophys Res Commun 376:694-99
9. Dalvi RR, Dalvi PS, Billups LH (2009) Comparative liver metabolism and toxicity of
carbon disulfide influenced by various inducers of P450 isoenzymes in rats. Toxicology International 16:83-89
10. Dalvi PS, Smith C, Mares B, Hubbard T, Brooks A, Ali K (2008) Effect of environmentally
realistic levels of mercuric chloride on hepatic P450 enzymes in rats after 14- and 90-day oral exposure. Toxicology International 15:1-6
11. Dalvi RR, Dalvi PS, Billups LH (2007) Involvement of CYP1A1 and CYP2E1 in N, N-
dimethyldithiocarbamate-mediated hepatocellular injury in rats: A possible role of oxidative stress. Current Topics in Toxicology 4:31-38
12. Goyal HO, Braden TD, Cooke PS, Szewczykowski MA, Williams CS, Dalvi P, Williams
JW (2007) Estrogen receptor alpha mediates estrogen-inducible abnormalities in the developing penis. Reproduction 133:1057-67
13. Goyal HO, Braden TD, Williams CS, Dalvi P, Mansour M, Williams JW (2005) Estrogen-
induced abnormal accumulation of fat cells in the rat penis and associated loss of fertility depends upon estrogen exposure during critical period of penile development. Toxicological Sciences 87:242-54
14. Goyal HO, Braden TD, Williams CS, Dalvi P, Mansour MM, Williams JW (2005)
Permanent induction of morphological abnormalities in the penis and penile skeletal muscles in adult rats treated neonatally with diethylstilbestrol or estradiol valerate: a dose-response study. Journal of Andrology 26:32-43
15. Dalvi RR, Dalvi PS, Lane C (2004) Cytochrome P450-mediated activation and toxicity of
chlorpyrifos in male and female rats. Veterinary and Human Toxicology 46:297-99
16. Goyal HO, Braden TD, Williams CS, Dalvi P, Williams JW, Srivastava KK (2004)
Exposure of neonatal male rats to estrogen induces abnormal morphology of the penis and loss of fertility. Reproductive Toxicology 18:265-74
17. Goyal HO, Braden TD, Williams CS, Dalvi P, Mansour MM, Mansour M, Williams JW,
Bartol FF, Wiley AA, Birch L, Prins GS (2004) Abnormal morphology of the penis in male rats exposed neonatally to diethylstilbestrol is associated with altered profile of estrogen receptor-alpha protein, but not of androgen receptor protein: a developmental and immunocytochemical study. Biology of Reproduction 70:1504-17
18. Dalvi PS, Wilder-Kofie T, Mares B, Dalvi RR, Billups LH (2003) Toxicologic implications
of the metabolism of thiram, dimethyldithiocarbamate and carbon disulfide mediated by hepatic cytochrome P450 isozymes in rats. Pesticide Biochemistry and Physiology 74:85-90
19. Dalvi PS, Wilder-Kofie T, Mares B, Lane C, Dalvi RR, Billups LH (2002) Effect of
cytochrome P450 inducers on the metabolism and toxicity of thiram in rats. Veterinary and Human Toxicology 44:331-33
20. Gawai KR, Vodela JK, Dalvi PS, Dalvi RR (1992) Comparative assessment of the effect of
aflatoxin B1 on hepatic dysfunction in some mammalian and avian species. Comparative Biochemistry and Physiology C101:415-18
21. Dalvi RR, Gawai KR, Dalvi PS (1991) Lack of in vitro and in vitro effects of fenbendazole
on phase I and phase II biotransformation enzymes in rats, mice and chickens. Veterinary and Human Toxicology 33:548-51
22. Dalvi RR, Dalvi PS (1991) Comparison of the effects of piperine administered
intragastrically and intraperitoneally on the liver and liver mixed-function oxidases in rats. Drug Metabolism and Drug Interactions 9:23-30
23. Dalvi RR, Dalvi PS (1991) Differences in the effects of piperine and piperonyl butoxide on
hepatic drug-metabolizing enzyme system in rats. Drug and Chemical Toxicology 14:219-29
Scientific Presentations / Abstracts
1. Dalvi PS, Erbiceanu FD, Irwin DM, Belsham DD (2012) Proglucagon Gene Expression is
Regulated by Insulin, Leptin and cAMP in Mouse Embryonic and Adult Hypothalamic Neuronal Cells. The 94th Annual Meeting of the Endocrine Society, Houston, USA
2. Purser MJ, Dalvi PS, Belsham DD (2011) The effects of ciliary neurotrophic factor on
mouse hypothalamic neuropeptides. The 93rd Annual Meeting of the Endocrine Society, Boston, USA
3. Dalvi PS, Purser MJ, Belsham DD (2010) Effect of exendin-4 on appetite-regulating
neuropeptides in the mouse hypothalamic neurons. The 92nd Annual Meeting of the Endocrine Society, San Diego, USA
4. Dalvi RR, Dalvi PS, Billups LH (2008) Potentiation of the hepatotoxicity of carbon
disulfide by chlordane-induced cytochrome P450 enzymes. FASEB J. 22:1137.5
5. Goyal HO, Braden TD, Williams CS, Mansour M, Dalvi PS, Mansour MM, Williams JW
(2004) A comparative dose-response study on the effect of DES and estradiol valerate on fertility and penile morphology in rats. 37th Annual Meeting of the Society for Study of Reproduction, Vancouver, BC, Canada
6. Dalvi PS, Horton R, Collins E, Wilder-Kofie T (2003) Comparative studies on the
metabolism of chlorpyrifos in male and female rats. Experimental Biology Annual Meeting, San Diego, CA, USA
7. Dalvi PS, Wilder-Kofie T, Mares B, Lane C, Dalvi RR, Billups LH (2003) Identification of
P450 enzymes involved in the metabolism and hepatotoxicity of carbon disulfide. Annual Society of Toxicology Convention, Salt Lake City, Utah, USA
8. St. Omer VV, Dalvi PS, Dalvi RR, Mizinga K, Datiri BC, Mansour M, Billups L, Abdalla
O, Lettsome S (2002) A replicate study of the multigenerational effect of low levels of chlordane on the liver and its cytochrome P-450 enzymes in rats. International Conference on Chemical Mixtures, Atlanta, GA, USA
9. Dalvi PS, Wilder-Kofie T, Mares B, Dalvi RR, Billups LH (2002) Metabolism and toxicity
of the fungicide thiram and its metabolites in rats. Toxicologist 66:126
10. Dalvi RR, Smith C, Mares B, Hubbard T, Brooks A, Ali K, Atkinson A, Dalvi PS (2002)
Effects of low levels of mercuric chloride on hepatic P450 enzymes in rats. FASEB J A946
11. Dalvi PS, Dalvi RR, St. Omer V, Mizinga K., Datiri BC, Mansour M, Billups L, Abdalla O
(2002) Multigenerational effect of low levels of chlordane on the liver and liver enzymes in rats. FASEB J. A946
12. Wilder-Kofie T, Dalvi PS, Mares B, Dalvi RR, Billups LH (2001) Metabolism and liver
toxicity of the fungicide thiram in rats. Annual NIH/MBRS Symposium, Orlando, FL, USA
13. Dalvi RR, Dalvi PS (1991) Effect of single and repeated administration of garlic oil on
biotransformation enzymes in rats. Toxicologist 11:298
Appl Microbiol Biotechnol (2000) 54: 792±798M. Saayman á H. J. J. van Vuuren á W. H. van ZylM. Viljoen-BloomDifferential uptake of fumarate by Candida utilisReceived: 15 March 2000 / Received revision: 4 July2000 / Accepted: 9 July2000Abstract The dicarboxylic acid fumarate is an impor- of the TCA cycle (Barnett and Kornberg 1960). Previoustant intermediate in cellular processes and also s
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