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Bovimec insert.qxp

RESIDUE INFORMATION:Cattle must not be treated within 48 days of slaugh- ter for human consumption. Because a withdrawal time in milk has not been established, do not use in female dairy cattle of breeding age. A withdrawal Consult your veterinarian for assistance in the diagnosis, treatment and control of parasitism.
period has not been established for this product in pre-ruminating calves.
Donot use in calves to be process for veal.
BOVIMEC (ivermectin) Pour-On delivers internal and external parasite control in one convenient low-volume application. BOVIMEC Pour-On contains ivermectin, a unique chemical entity.
W A R N I N G ! N O T F O R U S E I N H U M A N S .
BOVIMEC Pour-On applied at the recommended dose level of 500 mcg/kg is indicated for the This product should not be applied to self or others because it may be irritating to human skin and effective control of these parasites.
eyes and absorbed through the skin. To minimize accidental skin contact, the user should wear a long- sleeved shirt and rubber gloves. If accidental skin contact occurs, wash immediately with soap and (adults and L4) (including inhibited stage) accidental eye exposure occurs, flush eyes immediately with water and seek medical attention.
Keep this and all drugs out of the reach of children. The Material Safety Data Sheets (MSDS) contains more detailed occupationaly safety information. To report adverse effects, obtain and MSDS or for assistance contactVirbac at 1-800-338-3659.
KEEP AW AY FROM HEAT, SPARKS, OPEN FLAME, AND OTHER SOURCES OF IGNITION.
Store away from excessive heat (104 F/40 C) and protect from light.
Use only in well-ventilated areas or outdoors.
Close container tightly when not in use.
Cattle should not be treated when hair or hide is wet since reduced efficacy may be experienced.
Do not use when rain is expected to wet cattle within six hours after treatment.
This product is for application to skin surface only. Do not give orally or parenterally.
Cloudiness in the formulation may occur when BOVIMEC (ivermectin) Pour-On is stored at temper- Allowing to warm at room temperature will restore the normal appearance without Antiparasitic activity of ivermectin will be impaired if the formulation is applied to areas of the skin with mange scabs or lesions, or with dermatoses or adherent materials, e.g., caked mud or manure.
Ivermectin has been associated with adverse reactions in sensitive dogs; therefore, BOVIMEC Pour- BOVIMEC Pour-On controls horn flies (Haematobia irritans) for up to 28 days after dosing. For On is not recommended for use in species other than cattle.
best results BOVIMEC Pour-On should be part of a parasite control program for both internal and external parasites based on the epidemiology of these parasites. Consult your veterinarian or an entomologist for the most effective timing of applications.
BOVIMEC Pour-On effectively controls all stages of cattle grubs. However, proper timing of treatment is important. For the most effective results, cattle should be treated as soon as possible after the end of the heel fly (warble fly) season. While this is not peculiar to ivermectin, destruction of Hypoderma BOVIMEC Pour-On has been proved to effectively control infections and to protect cattle from larvae (cattle grubs) at the period when these grubs are in vital areas may cause undesirable host- re-infection with Ostertagia ostertagi, Oesophagostomum radiatum, Haemonchus placei, parasite reactions. Killing Hypoderma lineatum when it is in the esophageal tissues may cause bloat; Trichostrongylus axei, Cooperia punctata and Cooperia oncophora for 14 days after treatment.
killing H. bovis when it is in the vertebral canal may cause staggering or paralysis.
Cattle should be treated either before or after these stages of grub development.
The dose rate is 1 mL for each 22 lb of body weight. The formulation should be applied along Cattle treated with BOVIMEC Pour-On at the end of the fly season may be re-treated with ivermectin the topline in a narrow strip extending from the withers to the tailhead.
during the winter without danger of grub-related reactions. For further information and advice on a planned parasite control program, consult your veterinarian.
Squeeze-Measure-Pour System (250 mL, 500 mL or 1 Liter Bottle with 25 mL Measuring Cap) Studies indicate that when ivermectin comes in contact with the soil, it readily and tightly binds to the Select the correct dose rate by rotating the adjuster cap in either direction to position the dose soil and becomes inactive over time. Free ivermectin may adversely affect fish or certain aquatic organisms. Do not permit cattle to enter lakes, streams or ponds for at least six hours after treatment.
Do not contaminate water by direct application or by the improper disposal of drug containers. Dispose Gently squeeze the bottle to fill to level (any excess will return to the bottle) and then tip and of containers in an approved landfill or by incineration.
As with other avermectins, ivermectin is excreated in the dung of treated animals and can BackPack (84.5 fl oz/2.5 L Pack and 169 fl. oz/5 L Pack).
inhibit the reproduction and growth of pest and benificial insects that use dung as a source Connect the applicator gun to the backpack as follows: Attach the open end of the draw-off of food and for reproduction. The magnitude and duration of such effects are species and tubing to the dosing equipment. (Because of the solvents used in the formulation, only the life-cycle specific. When according label directions, the product is not expected to have an Protector Drench Gun from Instrument Supplies Limited, or equivalent, is recommended. Other adverse impact on populations of dung-dependent insects.
applicators may exhibit compatibility problems resulting in locking, incorrect dosage or leakage.) Replace the shipping cap with the draw-off cap and tighten down.
BOVIMEC Pour-On is available in an 8.5 fl oz/250 mL and 33.8 fl oz/1 liter bottle with a measure- Attach draw-off tubing to the draw-off cap.
pour system, an 84.5 fl oz/2.5 L or a 169 fl oz/5 L backpack intended for use with appropriate auto- Gently prime the applicator gun, checking for leaks.
Follow the manufacturer’s directions for adjusting the dose.
When the interval between uses of the applicator gun is expected to exceed 12 hours, disconnect the gun and draw-off tubing from the product container and empty the product from the gun and tubing back into the product container.
To prevent removal of special lubricants from the BOVIMEC is a trademark of Virbac AH, Inc.
Protector Drench Gun, the gun and tubing must not be washed.
Ivermectin is a member of the macrocylic lactone class of endectocides which have a qunique mode of action. Compounds of the class bind selectively and with high affinity to glutamate-gated chloride ion channels which occur in invertebrate nerve and muscle cells. This leads to an increase in the permeability of the cell membrane to chloride ions with hyperpolarization of the nerve or mus- cle, resulting in paralysis and death of the parisite. Compounds of this class may also interact with other ligand-gated chloride channels, such as those gated by the neurotransmitter gamma- aminobutyric acid or GABA. The margin of safety for compounds of this class is attributable to the fact that mammals do not have the glutamate-gated chloride channel, the macrocyclic lactonas have a low affinity for mammalian ligand-gated chlorid channel and they do not readily cross the Studies conducted in the U.S.A. have demonstrated the safety margin for ivermectin. Based on plasma levels, the topically applied formulation is expected to be at least as well tolerated by breeding animals as is the subcutaneous formulation which had no effect on breeding performance.

Source: http://www.ecrproducts.com/images/msds/Bovimec_Insert.pdf

Doi:10.1016/s0140-6736(06)69474-9

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