Microsoft word - acute toxins.doc

REPRODUCTIVE TOXINS
OSHA Laboratory Standard Definition: Reproductive toxin means chemicals which affect the reproductive capabilities including chromosomal damage
(mutations) and effects on fetuses (teratogenesis).
CHEMICAL NAME
CAS NUMBER
Angiotensin converting enzyme (ACE inhibitors) Bischloroethyl nitrosurea (BCNU) (carmustine) 1,4-Butanediol dimethylsulfonate (busulfan) 1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) Demeclocycline hydrochloride (internal use) Ethylene glycol monomethyl ether acetate Minocycline hydrochloride (internal use) Norethisterone acetate (norethindrone acetate) Norethisterone (norethindrone)/ethinyl estradiol Norethisterone (norethindrone)/mestranol Oxytetracycline hydrochloride (internal use) 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) Female and Male Reproductive Toxins
CHEMICAL NAME
CAS NUMBER
FEMALE REPRODUCTIVE TOXINS
MALE REPRODUCTIVE TOXINS
Lists taken from: http://www.hawaii.edu/ehso/lab/list.htm Highly Acute Toxins
Abrin N-Acetoxy-2-acetylaminofluorene Actinomycin D Aldicarb o-Aminoazobenzene 2-Aminofluorene Anabasine Apholate Arsenious Acid, Monosodium Salt Arsenic trioxide Atropine N,N-bis(2-chloromethyl)-2-Naphthylamine Bromoethyl methanesulfonate 1,4-Butanediol dimethylsulfonate Canthardin 2-Chloro-4-dimethyl-amino-6-methylpyrimidine Cyanogen Bromide Cyclophosphamide (2-bis(2-chloroethyl)-aminotetrahydro-2H-1,3,2- oxazaphosphorine-2-oxide) Diazomethane Digalen Digifolin Digoxin 7,12-Dimethylbenze[a]anthracene 3,3'-Dimethoxybenzidine 3,3'-Dimethylbenzidine Dimethylethylenimine 1,2-Dimethylhydrazine 3,3'-Dimethoxybenzidine dihydrochloride 1,4-Dinitrosopiperazine Duboisine Ethionine Ethylenimine Ethylene glycol dinitrate Ethyl methanesulfonate Fluroactetic acid Gitalin Heroin Hexaethyl tetraphosphate Hydrazoic acid Hydrocyanic acid N-Hydroxy-2-acetylaminofluorene Hyoscyamine Inorganic arsenic Isobenzan K-Strophanthin Lanatoside Lysergic acid diethylamide 3-Methylcholanthrene Methyl chloromethyl ether 4,4'-Methylene bis-(2-chloraniline) Methylhydrazine Methyl methanesulfonate Nicotine salicylate N-[4-(5-Nitr o-2-furyl)-2-thiazoly]-formamide Nitroglycerin N-Nitroquinoline-1-oxide N-Nitrosodimethylamine N-Nitroso-N-methylurethane Pantopon Parathion Paroxon Phosphine Phosphorodithioic acid Phosphorous (Yellow) Propylenimine 2-Propylpiperidine Ricin Scopolamine Sarin Sodium Azide Sodium Selenate Sulfotepp Tabun Tepp 2,3,7,8-Tetrachlorodibenzofuran Thimet m-Toluenediamine Uracil mustard Compounds with a high level of acute toxicity are defined by LD50 and LC50 levels. SELECT CARCINOGENS
*This list is based on the OSHA Select Carcinogen definition at the bottom of this
document as of October 2009.
OSHA - Occupational Safety and Health Administration, U.S. Department of Labor
Group ORC: OSHA Regulated Carcinogen
Group S: OSHA Select Carcinogen
IARC - International Agency for Research on Cancer
Group 1: Carcinogenic to humans
Group 2A: Probably carcinogenic to humans
Group 2B: Possibly carcinogenic to humans
NTP - National Toxicology Program, Public Health Service, U.S. Department of Health
and Human Services
Group 1: Known to be Human Carcinogens (K)
Group 2: Reasonably Anticipated to be Human Carcinogens (R)
CHEMICAL NAME
CAS NUMBER
OSHA IARC NTP
AF-2[2-(2-Furyl)-3-(5-nitro-2-furyl)acrylamide] 2-Amino-5-(5-nitro-2-furyl)-1,3,4-thiadiazole Amino-alpha-C (2-Amino-9h-pyrido[2,3-b]indole) Analgesic mixtures containing phenacetin Arsenic acid, disodium salt, heptahydrate Arsenic, elemental, and inorganic compounds, as As Bitumens, extracts of steam-refined and air-refined (Busulphan;Myleran) Butylated hydroxyanisole (BHA) Cadmium, elemental, and compounds, as Cd Chlorinated paraffins (C12, 60% Chlorine) Chlorinated paraffins (C23, 43% chlorine) alpha-Chlorinated toluenes (Benzal chloride, Benzyl chloride, Benzotrichloride)and bonzoyl chloride (combined exposures) 2-(4-Chloro-2-methyl phenoxy) propionic acid para-Chloro-ortho-toluidine and its strong acid salts 1-(2-Chloroethyl)-3-(4-methylcyclohexyl)-1- nitrosourea (Methyl-CCNU; Semustine) 1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) Polychlorophenols and their sodium salts (mixed 2-(o-Chlorophenyl)-2-(p-chlorophenyl)-1,1,1- trichloroethane 2-(o-Chlorophenyl)-2-(p-chlorophenyl)-1,1- Chromate(1-), Hydroxyoctaoxodizincatedi-, Potassium Chromic acid, Lead(2+) Salt (1:1) Coal tar pitch volatiles, as benzene solubles Cobalt (II) carbonate hydroxide (2:3) monohydroxide Cobalt carbonate, Cobalt dihydroxide (2:3) Cobalt, (mu-(Carbonato(2-)-O:O'))Dihydroxydi Cobalt, di-mu-carbonylhexacarbonyldi-, (Co-Co) Dantron (Chrysazin; 1,8-Dihydroxyanthraquinone, 3,3'-Dichloro-4,4'-diaminodiphenyl ether 3,3'-Dichlorobenzidine and 3,3'-Dichlorobenzidine hydrochloride 3,3'-Dichlorobenzidine dihydrochloride 3,3'-Dimethoxybenzidine (ortho-Dianisidine) trans-2-[(Dimethylamino)methylimino]-5-[2-(5-nitro-2- furyl)vinyl]-1,3,4-oxadiazole para-Dimethylaminoazobenzene Estrogens (not conjugated) Estradiol-17 beta Estrogens (not conjugated) Ethinylestradiol FireMaster BP-6 (under polybrominated biphenyls) 2-(2-Formylhydrazino)-4-(5-nitro-2-furyl)thiazole Glu-P-1 (2-Amino-6-methyldipyrido[1,2-a:3',2'- d]imidazole) Glu-P-2 (2-Aminodipyrido[1,2-a:3',2'-d]imidazole) IQ (2-Amino-3-methylimidazo[4,5-f]quinoline) Kanechlor (under polychlorinated biphenyls) Mea-alpha-c (2-Amino-3-methyl-9H-pyrido[2,3- MelQ (2-Amino-3,4-dimethylimidazo[4,5f]quinoline 2-Methyl-1-nitroanthraquinone (uncertain purity) n-Methyl-N'-nitro-N-nitrosoguanidine (MNNG) 4,4'-Methylene bis(n,n-dimethyl)benzenamine Mineral Oil, petroleum distillates with certain solvent and hydrotreatments. Consult MSDS for product status Mirex 5-(Morpholinomethyl)-3-[(5-nitrofurfurylidene)amino]- Nickel alloy, Ni 47-59,Co 17-20,Cr 13-17,Mo 4.5- 5.7,Al 3.7-4.7,Ti 3-4,Fe 0-1,C 0- 0.1 (AISI 687) Nickel biscyclopentadiene Nickel, compd with pi-Cyclopentadienyl (1:2) Nitrilotriacetic acid disodium salt monohydrate Nitrilotriacetic acid trisodium salt monohydrate N-[4-(5-Nitro-2-furyl)-2-thiazolyl]acetamide 1-[(5-Nitrofurfurylidene)amino]-2-imidazolidinone 4-(N-Nitrosomethylamino)-1-(3-pyridyl)-1-butanone (NNK) 3-(N-Nitrosomethylamino)propionitrile Palygorskite (attapulgite) (long fibres, > 5 micrometers) Panfuran S (containing dihydroxymethylfuratrizine) PhlP (2-Amino-1-methyl-6-phenyl-imidazo[4,5- b]pyridine) Piperazine Estrone Sulfate (under conjugated estrogens) Polybrominated biphenyl (FF-1) Polychlorophenols and their sodium salts (mixed exposures) Polycyclic aromatic hydrocarbons (PAHs) Sodium estrone sulfate (under conjugated estrogens) Sodium equilin sulfate (under conjugated estrogens) 2,3,7,8-Tetrachlorodibenzo-para-dioxin (TCDD) Toxins derived from Fusarium moniliforme Trichlormethine (trimustine hydrochloride) Trp-P-1 (3-Amino-1,4-dimethyl-5H-pyrido[4,3- b]indole) Trp-P-2(3-Amino-1-methyl-5H-pyrido[4,3-b]indole) Select Carcinogens Definition

A carcinogen is any substance or agent that is capable of causing cancer – the
abnormal or uncontrolled growth of new cells in any part of the body in humans or
animals. Carcinogens are chronic toxins with long latency periods that can cause
damage after repeated or long duration exposures and often do not have immediate
apparent harmful effects.
The OSHA Lab Standard defines a “Select Carcinogen” as any substance, which meets
one of the following criteria:
(i) It is regulated by OSHA as a carcinogen; or (ii) It is listed under the category, "known to be carcinogens," in the Annual Report on Carcinogens published by the National Toxicology Program (NTP) (latest edition); or (iii) It is listed under Group 1 ("carcinogenic to humans") by the International Agency for Research on Cancer Monographs (IARC) (latest editions); or (iv) It is listed in either Group 2A or 2B by IARC or under the category, "reasonably anticipated to be carcinogens" by NTP, and causes statistically significant tumor incidence in experimental animals in accordance with any of the following criteria: (A) After inhalation exposure of 6-7 hours per day, 5 days per week, for a significant portion of a lifetime to dosages of less than 10 mg/m(3); (B) After repeated skin application of less than 300 (mg/kg of body weight) per week; or (C) After oral dosages of less than 50 mg/kg of body weight per day. With regard to mixtures, OSHA requires that a mixture, “shall be assumed to present a carcinogenic hazard if it contains a component in concentrations of 0.1% or greater, which is considered to be carcinogenic.” Note that the potential for carcinogens to result in cancer can also be dependent on other “lifestyle” factors such as: • Cigarette smoking • Alcohol consumption • Consumption of high fat diet • Geographic location – industrial areas and UV light exposure • Therapeutic drugs • Inherited conditions More information on carcinogens, including numerous useful web links such as a listing of OSHA regulated carcinogens, can be found on the The State of California has developed an extensive list of “.” Cal/OSHA Regulated Carcinogens
Asbestos 2-Acetylaminofluorene Acrylonitrile 4-Aminodiphenyl Benzene Benzidine and its salts 1,3-Butadiene Cadmium bis-Chloromethyl Ether Coke oven emissions Chromium(IV) compounds 1,2-Dibromo-3-chloropropane 3,3'-Dichlorobenzidine and its salts 4-Dimethylaminoazobenzene Ethylene dibromide Ethyleneimine Ethylene oxide Formaldehyde Inorganic arsenic Lead Methyl Chloromethyl Ether Methylene chloride Methylenedianiline 4,4’-Methylene bis(2-chloroaniline) alpha-Naphthylamine beta-Naphthylamine 4-Nitrobiphenyl N-Nitrosodimethylamine beta-Propiolactone Vinyl Chloride Potentially Explosive Lab Chemicals
Acetyl peroxide Acetylene Ammonium nitrate Ammonium perchlorate Ammonium picrate Ba/Pb/Hg azide (heavy metal azides) Li/K/Na azide Organic azides Benzoyl peroxide Bromopropyne Butanone peroxide Cumene peroxide Diazodinitrophenol Dinitrophenol Dinitrophenylhydrazine Dinitroresorcinol Dipicryl amine Dipicryl sulphide Dodecanoyl peroxide Ethylene oxide Lauric peroxide MEK peroxide Mercury fulminate, Silver fulminate Nitrocellulose Nitrogen trifluoride Nitrogen triiodide Nitroglycerine Nitroguanidine Nitromethane Nitrourea Picramide Picric acid (trinitrophenol) Picryl chloride Picryl sulphonic acid Propargyl bromide (neat) Sodium dinitrophenate Succinic peroxide Tetranitroaniline Trinitroaniline Trinitroanisole Trinitrobenzene Trinitrobenzenesulphonic acid Trinitrobenzoic acid Trinitrocresol Trinitronaphthalene Trinitrophenol (picric acid) Trinitroresorcinol Trinitrotoluene Urea nitrate Potentially Explosive Compound Classes
Functional Groups:
Aromatic or Aliphatic Nitramine (=N-NO2) (-NH-NO2) Explosive Salts:
Picramate salts (2-amino-4,6-dinitrophenoxide) Pyrophoric Lab Chemicals
Examples: Et3Al, Et2AlCl, EtAlCl2, Me3Al, Diethylethoxyaluminium Grignard Reagents: RMgX (R=alkyl, aryl, vinyl X=halogen) Lithium Reagents: RLi (R = alkyls, aryls, vinyls) Examples: Butyllithium, Isobutyllithium, sec-Butyllithium, tert-Butyllithium, Ethyllithium, Hexyllithium, Isopropyllithium, Methyllithium, (Trimethylsilyl)methyllithium, Phenyllithium, 2-Thienyllithium, Vinyllithium, Lithium acetylide ethylenediamine complex, Lithium (trimethylsilyl)acetylide, Lithium phenylacetylide Metal carbonyls: Lithium carbonyl, Nickel tetracarbonyl, Dicobalt octacarbonyl Metal powders (finely divided): Bismuth, Calcium, Cobalt, Hafnium, Iron, Magnesium, Low Valent Metals: Titanium dichloride Metal hydrides: Potassium Hydride, Sodium hydride, Lithium Aluminum Hydride, Diethylaluminium hydride, Diisobutylaluminum hydride, Dichloro(methyl)silane Nonmetal hydrides: Arsine, Boranes, Diethylarsine, diethylphosphine, Germane, Phosphine, phenylphosphine, Silane, Methanetellurol (CH3TeH) Non-metal alkyls: R3B, R3P, R3As; Tetramethylsilane, Tributylphosphine Used hydrogenation catalysts: Activated Copper fuel cell catalysts, e.g. Cu/ZnO/Al2O3 Finely Divided Iron Sulfides (FeS, FeS2, Fe3S4), and Potassium Sulfide (K2S), Elements: Phosphorus Cesium Lithium Potassium Sodium Sodium Potassium Alloy (NaK)

Source: http://ehs.ucla.edu/Pub/CompleteToxinsList.pdf