PROJEKTPLAN – T5 Examensarbete på grundnivå (Kandidat)
(Obs! All information skall rymmas på denna sida) ________________________________________________________________________________________________ STUDENT Namn: Jonathan Björnsson
Adress: LU, BMC, Sölveg 19, 22184 Lund, Sweden
Adress: LU, BMC, Sölveg 19, 22184 Lund, Sweden
PROJEKTTITEL A field study to characterize the typical type 2 diabetes patients in Nepal regarding etiology, life style, modes of diagnosis, treatment, co-morbid conditions and complications. ______________________________________________________________________________________________ Sammanfattning (målsättning/frågeställning, arbetsplan, betydelse) Projektplanen formuleras av studenten i samråd med handledaren. Examinator utses av handledaren. Obs! Ska rymmas inom nedan ruta på denna sidan! (använd enkelt radavstånd och teckenstorlek 10 pkt) Diabetes Mellitus is a chronic, metabolic disease that causes high blood glucose levels. In Sweden, the prevalence of diabetes is 3-4 %, and more than 80% of these patients have type-2 diabetes (T2D), which is characterized by insulin- resistance and relative insulin deficiency. T2D is usually present in patients over 40 years of age, and is strongly related (80%) with obesity, physical inactivity and to some extent hereditary. One method to diagnose T2D is to measure fasting plasma glucose concentration on at least two different time points. If the measured value exceeds 7.0 mM/L the patient is diagnosed with diabetes. Initially it is treated with life-style modification, often in combination with an oral antidiabetic agent called Metformin. The comprehensive treatment goal is to achieve a HbA1c level below 6,5% and to establish a healthy lipid profile. Poorly managed diabetes can lead to persistent hyperglycaemia which can result in a long-term damage to various organs and cause cardiovascular disease, kidney failure, diabetic neuropathy and diabetic retinopathy. The prevalence of diabetes, especially T2D, is increasing world-wide much due to changes in life style. Our objective is to investigate the etiology, diagnosis, co-morbid conditions, complications and treatment of the typical type 2 diabetes patients in Nepal. Specifically, we will examine the: 1) Etiology: Who develops the disease? Are there any ethnic variations of great significance regarding the onset of the disease? 2) Diagnosis: How is T2D diagnosed in Nepal? What is the average fasting blood glucose in patients at first presentation? What is the average HbA1c in patients at first presentation? 3) Treatment, complications surveillance and glycemic outcomes: What types of treatments are used? Are the patients being monitored for complications and risk factors including: lipid profiles, serum creatinine, urine microalbumin, smoking, hypertension (evaluation and treatment)? Are the patients achieving target HbA1cs? and 4)Co-morbidities and complications: What are the common co-morbidities and end-organ complications for patients with T2D in Nepal? We are going to obtain data from charts regarding etiology, diagnosis and treatment. To investigate if obesity is a predisposing factor, we are going to obtain data of BMI and hip/waist-ratio. We are also going to look at the lipid profile on patients with T2D and correlate it to the BMI and hip/waist-ratio. In addition, we will obtain HbA1c, serum creatinine, HbA1c, data on co-morbid conditions and complications from chart reviews. Our study will take place in Patan, Nepal, at the Patan hospital, the major teaching hospital for the Patan Academy of Health sciences. Our main supervisor there will be Dr Arjun Karki who is appointed as the first Vice Chancellor of the Patan Academy of Health Sciences by the government of Nepal and Dr Subarna Dhital, endocrinologist at Patan Hospital. We will mainly be supervised by Dr Subarna Dhital. We expect to learn a great deal about the healthcare in Nepal, especially regarding type-2 diabetes. We also look forward to learning how to gather information and compile a report. Undertecknade åtager oss handledning och examinering av ovanstående students/studenters projektarbete. Etisk ansökan är gjord: Ja Nej den . /. 20.
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