Campus Address:
Department of Pharmaceutical Sciences--206TF School of Pharmacy
Telephone: Office -- (617) 373-4182 (or 373-3202)
EDUCATION Institution Degree/Date
PROFESSIONAL EXPERIENCE
Research Assistant, Department of Pharmacology, Cornell University Medical
Assistant Professor of Pharmacology and Physiology, Section of Pharmacology,
Northeastern University, College of Pharmacy and Allied Health Professions,
Head, Section of Pharmacology, Northeastern University, College of Pharmacy and
Director, M.S. in Pharmacology Program, Graduate School of Pharmacy and Allied
Associate Professor of Pharmacology (Tenured, 1983), Section of Pharmacology,
Northeastern University, College of Pharmacy and Allied Health Professions, 1983 -
Associate Professor of Pharmacology, Department of Pharmaceutical Sciences,
Northeastern University, Bouvé College of Pharmacy and Health Sciences, 1992 – 1998.
Associate Professor of Pharmacology, Department of Pharmaceutical Sciences,
Northeastern University, Bouvé College of Health Sciences, School of Pharmacy, 1999 -
PROFESSIONAL MEMBERSHIPS
Registered Pharmacist, State of Maine, 1970.
American Association of Colleges of Pharmacy, 1979; 1999 -
International Brain Research Organization, 1984 -
American Society for Pharmacology and Experimental Therapeutics, 1985 -
HONORARY SOCIETIES AND OTHER HONORS
American Men and Women of Science, 14th ed.
Pharmaceutical Manufacturers Association Visitation Program, Roche Laboratories,
Who's Who in Frontier Science and Technology, 1984.
RESEARCH INTERESTS
Animal models for anxiolytic-sedative-hypnotic tolerance and dependence.
Neuronal mechanisms of benzodiazepine tolerance and dependence.
GABA (subeffectiveness) hypothesis for benzodiazepine withdrawal.
Pharmacology of neurally released GABA in the substantia nigra using brain
PUBLICATIONS
Okamoto M and Boisse NR. Effect of chronic pentobarbital treatment of blood-
cerebral fluid kinetics. Eur. J. Pharmacol. 33: 205-209, 1975.
Okamoto M, Rosenberg HC, and Boisse NR. Tolerance characteristics
produced during the maximally tolerable chronic pentobarbital dosing
in the cat. J. Pharmacol. Exp. Ther. 192: 555-564, 1975.
Okamoto M, Rosenberg HC, and Boisse NR. Withdrawal characteristics following chronic pentobarbital dosing in the cat. Eur. J. Pharmacol. 40: 107-119.
Okamoto M, Rosenberg HC, and Boisse NR. "Barbiturate Withdrawal
Syndrome in Cats". In: Alcohol Intoxication and Withdrawal, Vol. 38. Milton
M. Gross, Ed., pp. 25-42, Plenum Publishing Corporation, New York, 1977.
Okamoto M, Rosenberg HC, and Boisse NR. Evaluation of anticonvulsants in
barbiturate withdrawal. J. Pharmacol. Exp. Ther. 202: 479-489, 1977.
Boisse NR and Okamoto M. Physical dependency to barbitral compared to
pentobarbital: Part I: "Chronically equivalent" dosing method. J.
Pharmacol. Exp. Ther. 204: 497-506, 1978.
Boisse NR and Okamoto M. Physical dependency to barbital compared to
pentobarbital: Part II: Tolerance characteristics. J. Pharmacol. Exp.
Publications (Cont’d)
Boisse NR and Okamoto M. Physical dependency to batbital compared to
pentobarbital: Part III: Withdrawal Characteristics. J. Pharmacol. Exp.
Boisse NR and Okamoto M. Physical dependency to barbital compared to
pentobarbital: Part IV: Influence of elimination kinetics. J. Pharmacol.
Okamoto M and Boisse NR. Comparison of ethanol and barbiturate
withdrawal. Proceedings of the 40th Annual Scientific Meeting,
Committee on Problems of Drug Dependence, pp. 444-461, 1978.
Okamoto M, Boisse NR, Rosenbert HC, and Rosen R. Characteristics of
functional tolerance during barbiturate physical dependency production.
J. Pharmacol. Exp. Ther. 207: 906-915, 1978.
Boisse NR and Okamoto M. "Ethanol as a Sedative-Hypnotic: Comparison
with Barbiturate and Non-Barbiturate Sedative Hypnotics." In: Alcohol
Tolerance and Dependence, H. Rigter and J. Crabbe, Eds., Ch. 11, pp.
265-292, Elsevier/North-Holland Biomedical Press, 1980.
Guarino JJ and Boisse NR. Physiology Experiments for the Health Professions,
Northeastern University Publishing Group, 1981.
Okamoto M and Boisse NR. "Sedative-Hypnotic Tolerance and Physical
Dependence." In: Trends in Pharmacological Science (TIPS), Elsevier
Boisse NR, Ryan GP, and Guarino JJ. Experimental induction of benzodiazepine
physical dependence in rodents. Proceedings of the 43rd Annual Scientific
Meeting, Committee on Problems of Drug Dependence 1981, L.S. Harris, Ed.,
NIDA Research Monograph 41: 191-199, 1982.
Ryan GP and Boisse NR. Experimental induction of benzodiazepine to tolerance
and physical dependence. J. Pharmacol. Exp. Ther. 226: 100-107, 1983.
Guarino JJ, Boisse NR and Campbell MD. Physiology Experiments for the
Health Professions, Second Edition, Northeastern University, Custom
Gay MH, Ryan GP, Boisse NR, and Guarino JJ. Phenobarbital tolerance and
physical dependence: chronically equivalent dosing model. Eur. J.
Ryan GP and Boisse NR. Benzodiazepine tolerance, physical dependence
and withdrawal: electrophysiological study of spinal reflex function. J.
Pharmacol. Exp. Ther. 231: 464-471, 1984.
Publications (Cont’d)
Boisse NR and Neumeyer JL. "Non-Barbiturate Sedatives and Hypnotics." In:
Handbook of CNS Agents and Local Anesthetics, Verderame M, ed., pp.
49-74, CRC Press, Inc., Boca Raton, FL, 1986.
Neumeyer JL and Boisse NR. "Drugs Used to Treat Neuromuscular Disorders;
Antiparkinsonism Agents and Skeletal Muscle Relaxants." In: Handbook
of CNS Agents and Local Anesthetics, Verderame M., ed., pp. 171-194,
Boisse NR, Periana RM, Guarino JJ and Kruger HS. Acute chlordiazepoxide
dependence in the rat: comparisons to chronic. In: Problems of Drug
Dependence 1985, Problems of Drug Dependence, Inc. Proceedings of
the 47th Annual Scientiic Meeting, Committee on Problems of Drug
Dependence, Inc., L.S. Harris, Ed., NIDA Research Monograph 67:
Boisse NR, Periana RM, Guarino JJ, Kruger HS and Samoriski GM.
Pharmacologic characterization of acute chlordiazepoxide dependence
in the rat. J. Pharmacol. Exp. Ther. 239: 775-783, 1986.
Boisse NR, Guarino JJ and Samoriski GM. Apparent lesser physical
dependence potential of nor-diazepam compared to diazepam in the rat.
In: Problems of Drug Dependence 1986, Problems of Drug Dependence,
Inc., Proceedings of the 48th Annual Scientific Meeting, Committee on
Problems of Drug Dependence, Inc., L.S. Harris, Ed., NIDA Research
Boisse NR, Samoriski GM and Guarino JJ. Flurothyl seizure thresholds
associated with acute and chronic chlordiazepoxide dependence and
withdrawal. In: Problems of Drug Dependence 1987, Problems of Drug
Dependence, Inc., Proceedings of the 49th Annual Scientific Meeting,
Committee on Problems of Drug Dependence, Inc., L.S. Harris, Ed.,
NIDA Research Monograph 81, pp. 109-114, 1988.
Boisse NR, Quaglietta N, Samoriski GM and Guarino JJ. Tolerance and
physical dependence to a short-acting benzodiazepine, midazolam. J.
Pharmacol. Exp. Ther. 252: 1125-1133, 1990.
27. Christensen, M, Boisse, NR, Sanchez, W, and Friedmann, PD. Enhancing
vocational rehabilitation counselors’ substance abuse screening and brief
intervention practices. J. of Vocational Rehabilitation 21: 157-163, 2004.
ABSTRACTS
Okamoto M, Rosenberg HC and Boisse NR. Tolerance characteristics
produced during the maximally tolerable chronic pentobarbital dosing in the
Boisse NR and Okamoto M. Comparison of barbital and pentobarbital
tolerance during equieffective chronic treatment. Pharmacologist 16: 247,
Boisse NR and Okamoto M. Comparison of barbital and pentobarbital
tolerance during equieffective chronic treatment. Pharmacologist 17:
Okamoto M, Boisse NR and Rosenberg HC. Evaluation of anticonvulsants in
barbiturate withdrawal. Fed. Proc. 34: 3169, 1975.
Okamoto M, Rosenberg HC and Boisse NR. Comparison of ethanol and
barbiturate withdrawal syndromes. Fed. Proc. 36: 331, 1977.
Okamoto M, Boisse NR and Rosenbert HC. Characteristics of functional
tolerance during barbiturate physical dependency production.
Ryan GP and Boisse NR. The production of benzodiazepine physical
dependence in rats. Eighth Annual Meeting, New England
Pharmacologists, Norwich, Connecticut, February 9-10, 1979.
Ryan GP and Boisse NR. The production of benzodiazepine physical
dependence in rats. Pharmacologist 21(3): 50, 1979.
Boisse NR and Ryan GP. Induction of tolerance and physical dependence to
phenobarbital in the rat. Fed. Proc. 39(3): 1326, 1980.
Boisse NR and Rivkin SM. Quantitative analysis of oxazepam in whole blood
by high pressure liquid chromatography. Tenth Annual Meeting, New
Ryan GP and Boisse NR. Alterations in excitatory spinal cord function during
benzodiazepine withdrawal. Fed. Proc. 40(3): 357, 1981.
Boisse NR and Rivkin SM. Simultaneous quantitation of chlordiazepoxide,
demoxepam, nor-chlordiazepoxide and nor-diazepam in blood by high
pressure liquid chromatography. Fed. Proc. 40(3): 2350, 1981.
Boisse NR, Ryan GP, Guarino JJ and Gay MH. Comparison of benzodia-
zepine and barbiturate tolerance and physical dependence in the rat.
ABSTRACTS (Continued)
Guarino JJ, Gay MH and Boisse NR. Benzodiazepine receptor binding: Effect
of flurothyl induced seizures. Proceedings of the New England
Pharmacologists Eleventh Annual Meeting, 1982.
Ryan GP and Boisse NR. Alterations in inhibitory spinal and cord function
during benzodiazepine withdrawal. Proceedings of the New England
Pharmacologists Eleventh Annual Meeting, 1982.
Ryan GP and Boisse NR. Rebound changes in synaptic transmission underlie
physical dependence and withdrawal following chronic high dose
benzodiazepine treatment. Fed. Proc. Abstracts, 7985, 1982.
Boisse NR, Gay MH, Guarino JJ, Kruger H and Ryan GP. Antagonist induced
withdrawal following chronic chlordiazepoxide dosing in the rat.
Guarino JJ, Gay MH and Boisse NR. Alterations in benzodiazepine receptor
binding following flurothyl induced seizures in the rat. Neuroscience
Guarino JJ, Boisse NR, Gay MH, Kruger HS and Periana R. Evidence for
common mechanism of spontaneous and precipitated benzodiazepine
withdrawal. Twelth Annual Meeting, New England Pharmacologists,
Boisse NR, Guarino JJ, Gay, MH, Kruger HS and Periana R. Quantitative
comparison of antagonist-precipitated and spontaneous chlordia-
zepoxide withdrawal in the rat. Forty-fifth Annual Scientific Meeting,
Committee on Problems of Drug Dependence, Lexington, KY,
Guarino JJ, Gay MH, Boisse NR, Kruger HS and Periana R. Ro15-1788
partially blocks development of chlordiazepoxide physical dependence
in the rat. Neurosci. Abstracts 9, 1983.
Kruger HS, Periana RM, Haase CA, Guarino JJ, Gay MH, Ryan GP and Boisse
NR. Comparison of chlordiazepoxide and phenobarbital for tolerance,
cross-tolerance, physical dependence and cross-dependence in the rat.
Thirteenth Annual Meeting, New England Pharmacologists, Woods
Brown DB, Callahan GB, Samoriski GM, Boisse NR and Guarino JJ. Detection
of protracted benzodiazepine withdrawal by analysis of fixed action
patterns of behavior. Pharmacologist 27(3): 308, 1985.
Guarino JJ, Boisse NR, Periana RM and Samoriski GM. Apparent lesser
dependence potential of diazepam and nor-diazepam compared to
chlordiazepoxide in the rat. Pharmacologist 27(3): 309, 1985.
ABSTRACTS (Continued)
Periana RM, Boisse NR, Guarino JJ and Kruger HS. Acute chlordiazpeoxide
dependence in the rat. Pharmacologist 27(3): 673, 1985.
Quaglietta N, Boisse NR, Guarino JJ and Periana RM. Experimental induction
of midazolam dependence in the rat by maximally tolerable loading.
Samoriski GM, Boisse NR, Quaglietta N and Guarino JJ. Induction of
midazolam dependence in the rat. In: Problems of Drug Dependence
1986, Proceedings of the 48th Annual Scientific Meeting, Committee on
Problems of Drug Dependence, Inc., L.S. Harris, Ed., NIDA Research
Samoriski GM, Boisse NR and Guarino JJ. Chronic chlordiazepoxide dose-
response study of anti-convulsant tolerance. Sixteenth Annual Meeting,
New England Pharmacologists, Westborough, MA, February 13-14, 1987.
Guarino JJ, Boisse NR and Gay MH. Differentiation of high vs low dose
benzodiazepine dependence in the rat. In: Problems of Drug
Dependence 1987, Proceedings of the 49th Annual Scientific Meeting,
Committee on Problems of Drug Dependence, Inc., L.S. Harris, Ed., NIDA
Boisse NR, Xie Y and Samoriski GM. GABA mediated chloride flux is not
altered during maximal benzodiazepine withdrawal. Neuro. Sci. Abstr.
Boisse NR, Samoriski GM and Xie YU. Effects of buspirone in the benzodiazepine
dependent rat. In: Problems of Drug Dependence 1989, Proceedings of the
51st Annual Scientific Meeting, Committee on Problems of Drug Dependence,
Inc., L.S. Harris, ed., NIDA Research Monograph. 95: 494, 1990.
Kermanidis P and Boisse NR. Selective changes in allosteric modulation
GABA-gated Cl- flux during maximal benzodiazepine withdrawal (Third IBRO
Boisse NR, Martin LP, Guarino JJ and Samoriski GM. Daily flumazenil dosing
during chlordiazepoxide dependence induction attenuates flumazenil
precipitated but not spontaneous withdrawal. Neurosci. Abstr. 18(1): 153.11,
Kermanidis P and Boisse NR. Further studies characterizing sensitization to
beta-carboline inhibition of GABA-gated chloride flux during maximal
benzodiazepine withdrawal. Boston Area Neuroscience Group (BANG-93)
Annual Scientific Meeting, January 12, 1993.
Leung J, Boisse NR and Amitay O. Sex differences in spontaneous withdrawal
following acute (single dose) benzodiazepine dependence induction. In:
Problems of Drug Dependence 1994, Proceedings of the 56th Annual
Scientific Meeting, College on Problems of Drug Dependence, Inc., L.S.
Harris, ed., NIDA Research Monograph. 153(II): 237, 1995.
Boisse NR, Amitay O and Leung J. Suppression of maximal benzodiazepine
withdrawal by pro-GABA-ergic drugs I. Chlordiazepoxide, phenobarbital,
sodium bromide and baclofen. In: Problems of Drug Dependence 1994,
Proceedings of the 56th Annual Scientific Meeting, College on Problems of
Drug Dependence, Inc.,L.S. Harris, ed., NIDA Research Monograph.
37. Boisse, NR, Christensen, M, Loring, R and Bateman, A. Interdisciplinary Nursing
Pharmacology: A Case Study Approach." presented at Northeastern
University Conference entitled this past summer at an NU conference
entitled "Academic Organizational Approaches to Transforming Health
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RE51-ALTERACIONES EN LA VASCULATURA OVÁRICA EN PACIENTES CON ALTA Y BAJA RESPUESTA A Scotti L1, Abramovich D1, Pascuali N1, Haro Durand L1, Bisioli C2, de Zúñiga I2, Tesone M1, Parborell F1. 1Instituto de Biología y Medicina Experimental (IByME-CONICET); 2PREGNA Medicina Reproductiva. RE54- ASOCIACION DE GLIPR1L1/GLIPR1L2 AL ESPERMATOZOIDE Y SU PARTICIPACION EN EL PROCESO DE FERTILIZACIÓN.