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Curriculum Vita of
NORMAN R. BOISSE

Campus Address:
Department of Pharmaceutical Sciences--206TF School of Pharmacy Telephone: Office -- (617) 373-4182 (or 373-3202)
EDUCATION
Institution
Degree/Date

PROFESSIONAL EXPERIENCE
Research Assistant, Department of Pharmacology, Cornell University Medical Assistant Professor of Pharmacology and Physiology, Section of Pharmacology, Northeastern University, College of Pharmacy and Allied Health Professions, Head, Section of Pharmacology, Northeastern University, College of Pharmacy and Director, M.S. in Pharmacology Program, Graduate School of Pharmacy and Allied Associate Professor of Pharmacology (Tenured, 1983), Section of Pharmacology, Northeastern University, College of Pharmacy and Allied Health Professions, 1983 - Associate Professor of Pharmacology, Department of Pharmaceutical Sciences, Northeastern University, Bouvé College of Pharmacy and Health Sciences, 1992 – 1998. Associate Professor of Pharmacology, Department of Pharmaceutical Sciences, Northeastern University, Bouvé College of Health Sciences, School of Pharmacy, 1999 -
PROFESSIONAL MEMBERSHIPS
Registered Pharmacist, State of Maine, 1970. American Association of Colleges of Pharmacy, 1979; 1999 - International Brain Research Organization, 1984 - American Society for Pharmacology and Experimental Therapeutics, 1985 -
HONORARY SOCIETIES AND OTHER HONORS
American Men and Women of Science, 14th ed. Pharmaceutical Manufacturers Association Visitation Program, Roche Laboratories, Who's Who in Frontier Science and Technology, 1984.
RESEARCH INTERESTS
Animal models for anxiolytic-sedative-hypnotic tolerance and dependence. Neuronal mechanisms of benzodiazepine tolerance and dependence. GABA (subeffectiveness) hypothesis for benzodiazepine withdrawal. Pharmacology of neurally released GABA in the substantia nigra using brain
PUBLICATIONS
Okamoto M and Boisse NR. Effect of chronic pentobarbital treatment of blood- cerebral fluid kinetics. Eur. J. Pharmacol. 33: 205-209, 1975. Okamoto M, Rosenberg HC, and Boisse NR. Tolerance characteristics produced during the maximally tolerable chronic pentobarbital dosing in the cat. J. Pharmacol. Exp. Ther. 192: 555-564, 1975. Okamoto M, Rosenberg HC, and Boisse NR. Withdrawal characteristics following chronic pentobarbital dosing in the cat. Eur. J. Pharmacol. 40: 107-119. Okamoto M, Rosenberg HC, and Boisse NR. "Barbiturate Withdrawal Syndrome in Cats". In: Alcohol Intoxication and Withdrawal, Vol. 38. Milton M. Gross, Ed., pp. 25-42, Plenum Publishing Corporation, New York, 1977. Okamoto M, Rosenberg HC, and Boisse NR. Evaluation of anticonvulsants in barbiturate withdrawal. J. Pharmacol. Exp. Ther. 202: 479-489, 1977. Boisse NR and Okamoto M. Physical dependency to barbitral compared to pentobarbital: Part I: "Chronically equivalent" dosing method. J. Pharmacol. Exp. Ther. 204: 497-506, 1978. Boisse NR and Okamoto M. Physical dependency to barbital compared to pentobarbital: Part II: Tolerance characteristics. J. Pharmacol. Exp. Publications (Cont’d)

Boisse NR and Okamoto M. Physical dependency to batbital compared to pentobarbital: Part III: Withdrawal Characteristics. J. Pharmacol. Exp. Boisse NR and Okamoto M. Physical dependency to barbital compared to pentobarbital: Part IV: Influence of elimination kinetics. J. Pharmacol. Okamoto M and Boisse NR. Comparison of ethanol and barbiturate withdrawal. Proceedings of the 40th Annual Scientific Meeting, Committee on Problems of Drug Dependence, pp. 444-461, 1978. Okamoto M, Boisse NR, Rosenbert HC, and Rosen R. Characteristics of functional tolerance during barbiturate physical dependency production. J. Pharmacol. Exp. Ther. 207: 906-915, 1978. Boisse NR and Okamoto M. "Ethanol as a Sedative-Hypnotic: Comparison with Barbiturate and Non-Barbiturate Sedative Hypnotics." In: Alcohol Tolerance and Dependence, H. Rigter and J. Crabbe, Eds., Ch. 11, pp. 265-292, Elsevier/North-Holland Biomedical Press, 1980. Guarino JJ and Boisse NR. Physiology Experiments for the Health Professions, Northeastern University Publishing Group, 1981. Okamoto M and Boisse NR. "Sedative-Hypnotic Tolerance and Physical Dependence." In: Trends in Pharmacological Science (TIPS), Elsevier Boisse NR, Ryan GP, and Guarino JJ. Experimental induction of benzodiazepine physical dependence in rodents. Proceedings of the 43rd Annual Scientific Meeting, Committee on Problems of Drug Dependence 1981, L.S. Harris, Ed., NIDA Research Monograph 41: 191-199, 1982. Ryan GP and Boisse NR. Experimental induction of benzodiazepine to tolerance and physical dependence. J. Pharmacol. Exp. Ther. 226: 100-107, 1983. Guarino JJ, Boisse NR and Campbell MD. Physiology Experiments for the Health Professions, Second Edition, Northeastern University, Custom Gay MH, Ryan GP, Boisse NR, and Guarino JJ. Phenobarbital tolerance and physical dependence: chronically equivalent dosing model. Eur. J. Ryan GP and Boisse NR. Benzodiazepine tolerance, physical dependence and withdrawal: electrophysiological study of spinal reflex function. J. Pharmacol. Exp. Ther. 231: 464-471, 1984. Publications (Cont’d)
Boisse NR and Neumeyer JL. "Non-Barbiturate Sedatives and Hypnotics." In: Handbook of CNS Agents and Local Anesthetics, Verderame M, ed., pp. 49-74, CRC Press, Inc., Boca Raton, FL, 1986. Neumeyer JL and Boisse NR. "Drugs Used to Treat Neuromuscular Disorders; Antiparkinsonism Agents and Skeletal Muscle Relaxants." In: Handbook of CNS Agents and Local Anesthetics, Verderame M., ed., pp. 171-194, Boisse NR, Periana RM, Guarino JJ and Kruger HS. Acute chlordiazepoxide dependence in the rat: comparisons to chronic. In: Problems of Drug Dependence 1985, Problems of Drug Dependence, Inc. Proceedings of the 47th Annual Scientiic Meeting, Committee on Problems of Drug Dependence, Inc., L.S. Harris, Ed., NIDA Research Monograph 67: Boisse NR, Periana RM, Guarino JJ, Kruger HS and Samoriski GM. Pharmacologic characterization of acute chlordiazepoxide dependence in the rat. J. Pharmacol. Exp. Ther. 239: 775-783, 1986. Boisse NR, Guarino JJ and Samoriski GM. Apparent lesser physical dependence potential of nor-diazepam compared to diazepam in the rat. In: Problems of Drug Dependence 1986, Problems of Drug Dependence, Inc., Proceedings of the 48th Annual Scientific Meeting, Committee on Problems of Drug Dependence, Inc., L.S. Harris, Ed., NIDA Research Boisse NR, Samoriski GM and Guarino JJ. Flurothyl seizure thresholds associated with acute and chronic chlordiazepoxide dependence and withdrawal. In: Problems of Drug Dependence 1987, Problems of Drug Dependence, Inc., Proceedings of the 49th Annual Scientific Meeting, Committee on Problems of Drug Dependence, Inc., L.S. Harris, Ed., NIDA Research Monograph 81, pp. 109-114, 1988. Boisse NR, Quaglietta N, Samoriski GM and Guarino JJ. Tolerance and physical dependence to a short-acting benzodiazepine, midazolam. J. Pharmacol. Exp. Ther. 252: 1125-1133, 1990. 27. Christensen, M, Boisse, NR, Sanchez, W, and Friedmann, PD. Enhancing vocational rehabilitation counselors’ substance abuse screening and brief intervention practices. J. of Vocational Rehabilitation 21: 157-163, 2004.
ABSTRACTS
Okamoto M, Rosenberg HC and Boisse NR. Tolerance characteristics produced during the maximally tolerable chronic pentobarbital dosing in the Boisse NR and Okamoto M. Comparison of barbital and pentobarbital tolerance during equieffective chronic treatment. Pharmacologist 16: 247, Boisse NR and Okamoto M. Comparison of barbital and pentobarbital tolerance during equieffective chronic treatment. Pharmacologist 17: Okamoto M, Boisse NR and Rosenberg HC. Evaluation of anticonvulsants in barbiturate withdrawal. Fed. Proc. 34: 3169, 1975. Okamoto M, Rosenberg HC and Boisse NR. Comparison of ethanol and barbiturate withdrawal syndromes. Fed. Proc. 36: 331, 1977. Okamoto M, Boisse NR and Rosenbert HC. Characteristics of functional tolerance during barbiturate physical dependency production. Ryan GP and Boisse NR. The production of benzodiazepine physical dependence in rats. Eighth Annual Meeting, New England Pharmacologists, Norwich, Connecticut, February 9-10, 1979. Ryan GP and Boisse NR. The production of benzodiazepine physical dependence in rats. Pharmacologist 21(3): 50, 1979. Boisse NR and Ryan GP. Induction of tolerance and physical dependence to phenobarbital in the rat. Fed. Proc. 39(3): 1326, 1980. Boisse NR and Rivkin SM. Quantitative analysis of oxazepam in whole blood by high pressure liquid chromatography. Tenth Annual Meeting, New Ryan GP and Boisse NR. Alterations in excitatory spinal cord function during benzodiazepine withdrawal. Fed. Proc. 40(3): 357, 1981. Boisse NR and Rivkin SM. Simultaneous quantitation of chlordiazepoxide, demoxepam, nor-chlordiazepoxide and nor-diazepam in blood by high pressure liquid chromatography. Fed. Proc. 40(3): 2350, 1981. Boisse NR, Ryan GP, Guarino JJ and Gay MH. Comparison of benzodia- zepine and barbiturate tolerance and physical dependence in the rat.
ABSTRACTS (Continued)
Guarino JJ, Gay MH and Boisse NR. Benzodiazepine receptor binding: Effect of flurothyl induced seizures. Proceedings of the New England Pharmacologists Eleventh Annual Meeting, 1982. Ryan GP and Boisse NR. Alterations in inhibitory spinal and cord function during benzodiazepine withdrawal. Proceedings of the New England Pharmacologists Eleventh Annual Meeting, 1982. Ryan GP and Boisse NR. Rebound changes in synaptic transmission underlie physical dependence and withdrawal following chronic high dose benzodiazepine treatment. Fed. Proc. Abstracts, 7985, 1982. Boisse NR, Gay MH, Guarino JJ, Kruger H and Ryan GP. Antagonist induced withdrawal following chronic chlordiazepoxide dosing in the rat. Guarino JJ, Gay MH and Boisse NR. Alterations in benzodiazepine receptor binding following flurothyl induced seizures in the rat. Neuroscience Guarino JJ, Boisse NR, Gay MH, Kruger HS and Periana R. Evidence for common mechanism of spontaneous and precipitated benzodiazepine withdrawal. Twelth Annual Meeting, New England Pharmacologists, Boisse NR, Guarino JJ, Gay, MH, Kruger HS and Periana R. Quantitative comparison of antagonist-precipitated and spontaneous chlordia- zepoxide withdrawal in the rat. Forty-fifth Annual Scientific Meeting, Committee on Problems of Drug Dependence, Lexington, KY, Guarino JJ, Gay MH, Boisse NR, Kruger HS and Periana R. Ro15-1788 partially blocks development of chlordiazepoxide physical dependence in the rat. Neurosci. Abstracts 9, 1983. Kruger HS, Periana RM, Haase CA, Guarino JJ, Gay MH, Ryan GP and Boisse NR. Comparison of chlordiazepoxide and phenobarbital for tolerance, cross-tolerance, physical dependence and cross-dependence in the rat. Thirteenth Annual Meeting, New England Pharmacologists, Woods Brown DB, Callahan GB, Samoriski GM, Boisse NR and Guarino JJ. Detection of protracted benzodiazepine withdrawal by analysis of fixed action patterns of behavior. Pharmacologist 27(3): 308, 1985. Guarino JJ, Boisse NR, Periana RM and Samoriski GM. Apparent lesser dependence potential of diazepam and nor-diazepam compared to chlordiazepoxide in the rat. Pharmacologist 27(3): 309, 1985. ABSTRACTS (Continued)

Periana RM, Boisse NR, Guarino JJ and Kruger HS. Acute chlordiazpeoxide dependence in the rat. Pharmacologist 27(3): 673, 1985. Quaglietta N, Boisse NR, Guarino JJ and Periana RM. Experimental induction of midazolam dependence in the rat by maximally tolerable loading. Samoriski GM, Boisse NR, Quaglietta N and Guarino JJ. Induction of midazolam dependence in the rat. In: Problems of Drug Dependence 1986, Proceedings of the 48th Annual Scientific Meeting, Committee on Problems of Drug Dependence, Inc., L.S. Harris, Ed., NIDA Research Samoriski GM, Boisse NR and Guarino JJ. Chronic chlordiazepoxide dose- response study of anti-convulsant tolerance. Sixteenth Annual Meeting, New England Pharmacologists, Westborough, MA, February 13-14, 1987. Guarino JJ, Boisse NR and Gay MH. Differentiation of high vs low dose benzodiazepine dependence in the rat. In: Problems of Drug Dependence 1987, Proceedings of the 49th Annual Scientific Meeting, Committee on Problems of Drug Dependence, Inc., L.S. Harris, Ed., NIDA Boisse NR, Xie Y and Samoriski GM. GABA mediated chloride flux is not altered during maximal benzodiazepine withdrawal. Neuro. Sci. Abstr. Boisse NR, Samoriski GM and Xie YU. Effects of buspirone in the benzodiazepine dependent rat. In: Problems of Drug Dependence 1989, Proceedings of the 51st Annual Scientific Meeting, Committee on Problems of Drug Dependence, Inc., L.S. Harris, ed., NIDA Research Monograph. 95: 494, 1990. Kermanidis P and Boisse NR. Selective changes in allosteric modulation GABA-gated Cl- flux during maximal benzodiazepine withdrawal (Third IBRO Boisse NR, Martin LP, Guarino JJ and Samoriski GM. Daily flumazenil dosing during chlordiazepoxide dependence induction attenuates flumazenil precipitated but not spontaneous withdrawal. Neurosci. Abstr. 18(1): 153.11, Kermanidis P and Boisse NR. Further studies characterizing sensitization to beta-carboline inhibition of GABA-gated chloride flux during maximal benzodiazepine withdrawal. Boston Area Neuroscience Group (BANG-93) Annual Scientific Meeting, January 12, 1993. Leung J, Boisse NR and Amitay O. Sex differences in spontaneous withdrawal following acute (single dose) benzodiazepine dependence induction. In: Problems of Drug Dependence 1994, Proceedings of the 56th Annual Scientific Meeting, College on Problems of Drug Dependence, Inc., L.S. Harris, ed., NIDA Research Monograph. 153(II): 237, 1995. Boisse NR, Amitay O and Leung J. Suppression of maximal benzodiazepine withdrawal by pro-GABA-ergic drugs I. Chlordiazepoxide, phenobarbital, sodium bromide and baclofen. In: Problems of Drug Dependence 1994, Proceedings of the 56th Annual Scientific Meeting, College on Problems of Drug Dependence, Inc.,L.S. Harris, ed., NIDA Research Monograph. 37. Boisse, NR, Christensen, M, Loring, R and Bateman, A. Interdisciplinary Nursing Pharmacology: A Case Study Approach." presented at Northeastern University Conference entitled this past summer at an NU conference entitled "Academic Organizational Approaches to Transforming Health

Source: http://nuweb4.neu.edu/bouve-faculty/resumes/44.pdf

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