Le métronidazole (Flagyl) reste la référence dans le traitement des infections anaérobies et des parasitoses comme la giardiase ou l’amibiase. Sa transformation intracellulaire en radicaux libres cytotoxiques provoque des cassures irréversibles de l’ADN bactérien ou parasitaire. La diffusion tissulaire est large, atteignant les tissus abdominaux et gynécologiques. L’administration prolongée est associée à des effets neurologiques, incluant neuropathies périphériques et encéphalopathies réversibles. L’association avec l’alcool déclenche une réaction de type antabuse. Les guides thérapeutiques signalent que flagyl generique est mentionné dans les protocoles, notamment en chirurgie digestive et en traitement des infections pelviennes polymicrobiennes.

Ors.umkc.edu2

Technology Available For License
Drug Delivery that Overcomes
P-glycoprotein Mediated Drug Efflux
A drug delivery system that overcomes the problems associated with P-glycoprotein mediated drug efflux. Disadvantages of Current Treatments:
P-Glycoprotein (P-gp) is a transport protein that effluxes a wide variety of structural y unrelated drugs out of cel s. The bioavailability of various anticancer drugs, anti-HIV drugs, calcium channel drugs, and other drugs which are substrates is limited by this efflux transporter. Over-expression of P-gp by tumor cel s confers multi-drug resistance. Efflux of many anticancer drugs including taxol, vincristine, vinblastine, actinomycin D, colchicines, and daunorubicin, from tumor cel s makes P-gp a major barrier to chemothera-py. High expression of this transporter on the blood-brain-barrier (BBB) restricts the entry into the brain of P-gp substrates such as anti-HIV drugs such as ritonavir, saquinavir, nelfinavir, and various anticancer drugs, and thus imposes a major chal enge in the treat-ment of various diseases of the brain. Expression of the efflux transporter on various body tissues and cel s not only influences the in vivo disposition of various therapeuti-cal y active drugs, but also greatly influences the drugs' pharmacokinetics. It has been known that inhibition of P-gp by various modulators can lead to improved bioavailability of drugs across the intestines, the kidneys, and the BBB. Various modulators that inhibit P-gp are often co-administered with other bioactive agents to increase bioavailability. However, use of these compounds is limited by their toxicity. To achieve P-gp inhibition, doses that result in high serum concentrations of the toxic inhibitor are required. Although various approaches have been studied to overcome P-gp mediated drug efflux, P-gp remains a major barrier to bioa-vailability, chemotherapy, and effective permeation of P-gp substrates into the brain and other tissues. Invention Details:
In response to these troublesome efflux issues, UMKC researchers have developed methods of: Converting drugs that are substrates for the P-gp transporter into derivatives not recognized by P-gp as substrates, preferably targeted to and recognized by an influx membrane transporter/receptor (such as a peptide, vitamin or other nutrient trans-porter). The efflux of such derivatives from cel s by the P-gp transporter is thereby eliminated or substantial y reduced while their transport into target cel s by one or more influx transporters/receptors can be effectively enhanced increasing the bioa-vailability of bioactive compounds that are P-gp substrates. Increasing the concentration of bioactive compounds that are P-gp substrates in sanctuary sites of a mammalian subject. Enhancing cel ular delivery of bioactive compounds that are P-gp substrates. Suggested Uses:
For use with various anticancer drugs, anti-HIV drugs, calcium channel drugs, and other drugs which are substrates limited by this efflux transporter. Advantages:
Inhibition of P-gp by various modulators can lead to improved bioavailability of drugs across the intestines, the kidneys, and the blood-brain barrier. Lower toxicity due to less drugs being administered. Please visit our website at: http://www.umkc.edu/ors/ott for a detailed description of this and other technologies. UMKC Office of Technology Transfer

Source: http://ors.umkc.edu/docs/techtransfer/drug-delivery-p-gp-efflux.pdf?sfvrsn=0

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obesity reviews Obesity Management Recent advances in adaptive thermogenesis: potential implications for the treatment of obesity S. L. J. Wijers, W. H. M. Saris and W. D. van Marken LichtenbeltDepartment of Human Biology, Nutrition andToxicology Research Institute Maastricht,Large inter-individual differences in cold-induced (non-shivering) and diet-induced adaptive thermogenesis exi

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Actualização de rendas Entrada em vigor: Contratos habitacionais anteriores a 1990 Contratos não habitacionais anteriores a 1995 Coeficiente de actualização – art. 24º da Lei 6/2006 Publicado no DR até 30 de Outubro de cada anoRegra geral a que poderemos ter de recorrer se a actualização nos termos do artigo 35º (RABC) for inferior ao valor que resultaria da actualizaç

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