Sdb - mb 8 e - crofab - englisch.doc

Serum-Depot Berlin e. V.
Merkblatt 8 - E
CROFAB TM
CROTALIDAE POLYVALENT IMMUNE FAB (OVINE)

DESCRIPTION
CroFabTM [Crotalidae Polyvalent Immune Fab (Ovine)] is a sterile, nonpyrogenic, purified,
lyophilized preparation of ovine Fab (monovalent) immunoglobulin fragments obtained from
the blood of healthy sheep flocks immunized with one of the following North American
snake venoms: Crotalus atrox (Western Diamondback rattlesnake), Crotalus adamanteus
(Eastern Diamondback rattlesnake), Crotalus scutulatus (Mojave rattlesnake), and
Agkistrodon piscivorus (Cottonmouth or Water Moccasin). To obtain the final antivenin
product, the tour different monospecific antivenins are mixed. Each monospecific antivenin is
prepared by fractionating the immunoglobulin from the ovine serum, digesting it with papain,
and isolating the venom-specific fab fragments on ion exchange and affinity chromatography
columns.
CroFab is standardized by its abiliry to neutralize the lethal action of each of the fcur venom
immunogens following intravenous injection in mice. The potency of the product will vary
from batch to batch; however, a minimum number of mouse LD50 neutralizing units against
each of the four venoms is included in every vial of final product, as shown in Table t. For
comparison, the minimum potency of each monospecitic component in the batches
demonstrated to be efficacious in clinical trials is also included in Table 1.
Table 1.
Minimum Mouse LD50 Neutralizin Units* for Each Venom Component
Minimum Potency per Vial of CroFab
Minimum Potency per Vial of Clinical Trial Batches
[95 % Reference Intervall]
*One neutralizing unit is determined as the amount of the mixed monospecific Fab proteins necessary to neutralize one LD50 of each of the four venoms, where the LD50
is the amount of venom that would be lethal in 50 % of mice.

Each vial of CroFab contains up to 1g of total protein and sodium phosphate buffer consisting
of dibasic sodium phosphate USP and sodium chloride USP. Thimerosal is used as a
preservative in the manufacturing process, and as such, mercury is carried over into the final
product at an amount no greater than 104.5 mcg per vial, which amounts to no more than 1.9
mg of mercury per dose (based on the maximum dose of 18 vials used in clinical studies of
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CroFab). The product is intended for intravenous administration after reconstitution with 10
ml of Sterile Water for Injection USP.
CLINICAL PHARMACOLOGY
Mechanism ot Action:
CroFab is a venom-specific Fab fragment of immunoglobulin G (IgG) that works by binding
and neutralizing venom toxins, facilitating their redistribution away from target tissues and
their elimination from the body.

Animal Studies:
CroFab was effective in neutralizing the venoms of 10 clinically important North American
crotalid snakes in a murine lethality model (see Table 2) [1]. In addition, preliminary data
from experiments in mice using whole IgG from the sheep immunized for CroFab production
suggest that CroFab might possess antigenic cross-reactivity against the venoms of some
Middle Eastern and North African snakes; however, there are no clinical data available to
confirm these findings.
Table 2. ED50 Values for CroFab in Mice
Stody Objective &
Endpoint
Major Findings and Conclusions
Measured
the ED50 for each (Note: Lower numbers represent increased potency againsl S. m. barbouri 7 C. h. horridus 6 Based on the data from this study in mice, CroFab has relatively good cross-protection against venoms not used in the immunization of flocks used to produce it, except for C. v helleri, where a very high dose is required, and for C. m. molossus, where a moderately high dose is required.
Clinical Pharmacokinetics:
The planned pharmacokinetic study of CroFab was not adequately performed. A limited
number of samples were collected from three patients. Based on these data, estimates of
elimination half-life were made. The elimination half-life for total Fab ranged from
approximately 12 to 23 hours. These limited pharmacokinetic estimates of half-life are
augmented by data obtained with an analogous ovine Fab product produced by Protherics Inc.
using a similar production process. In that study, 8 healthy subjects were
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given 1 mg of intravenous digoxin followed by an approximately equimolar neutralizing dose
of 76 mg of digoxin immune Fab (ovine). Total Fab was shown to have a volume of
distribution of 0.3 L/kg, a systemic clearance of 32 mL/min (approximately 0.4 mL/min/kg)
and an elimination half-life of approximately 15 hours.
Clinical Studies:
No clinical studies have been conducted comparing CroFab with other antivenins,
therefore, no comparisons can be made belween CroFab and other antivenins.

Two clinical trials using CroFab have been conducted. They were prospectivefy defined,
open-label, muhl-center trials conducted in otherwise healthy patients 11 years of age or older
who had suffered from minimal or moderate (as defined in Table 3) North American crotalid
envenomation that showed evidence of progression. Progression was defined as the
worsening of any evaluation parameter used in the grading of an envenomation: local injury,
laboratory abnormality or symptoms and signs attributable to crotalid snake venom
poisoning. Both clinical trials excluded patients with Copperhead envenomation. To date,
there are no clinical data supporting the efficacy of CroFab in patients presenting with severe
envenomation.
Table 3. Definitian of Minimal, Moderate, and Severe Envenomation in Clinical Studies
of CroFab
Envenomalian
Definition
Category
Swelling, pain and ecchymosis limited to the immediate bite site; Coagulation parameters normal with no clinical evidence of bleeding. Swelling, pain, and ecchymosis involving less than a full extremity or, if bite was sustained on the trunk, head or neck, extending less than 50 cm; Systemic signs and symptoms may be present but not life threatening, including but not limited to nausea, vomiting, oral paresthesia or unusual tastes, mild hypotension (systolic blood pressure <90 mmHg), mild tachycardia (heart rate <150), and tachypnea; Coagulation parameters may be abnormal, but no clinical evidence of bleeding present. Minor hematuria, gum bleeding and nosebleeds are ailowed if they are not considered severe in the investigatof`s judgment. Swelling pain, and ecchymosis involving more than an entire extremity or threatening the airway; Svstemic signs and symptoms are markedly abnormal, including severe alteration of mental status, severe hypotension, severe tachycardia, tachypnea, or respiratory insufficiency; Coagulation parameters are abnormal, with serious bleeding or severe threat of bleeding. In both clinical studies, efficacy was determined using a Snakebite Severity Score (SSS) [2] (referred to as the efficacy score or ES in these clinical studies) and an investigator's clinical assessment (ICA) of efficacy. The SSS (referred to as the ES) is a tool used to measure the severity of envenomation based on six body categories; local wound (e.g.,.pain, swelling and ecchymosis), pulmonary, cardiovascular, gastrointestinal, hematological, and nervous system SDB; Merkblatt 8 - E
effects. A higher score indicates worse symptoms. In a retrospective study using medical
records of 108 snakebite victims [2], the SSS has been shown to correlate well with physi-
cians' assessment of the patient's condition at presentation (Pearson correlation coefficient:
r=0.63, p<0.0001) and when the patient's condition was at its worst (r=0.70, p<0.0001). In
this study, the condition of 87/108 patients worsened during hospitalization. Changes in the
physicians' assessment of condition correlated well with changes in SSS. CroFab was
required to prevent an increase in the ES in order to demonstrate efficacy.
The ICA was based on the investigator's clinical judgment as to whether the patient had a:
· Clinical response (pre-treatment signs and symptoms of envenomation were arrested or
improved after treatment)
· Partial response (signs and symptoms of envenomation worsened, but at a slower rate than
expected after treatment)
· Non-response (the patient's condition was not favorably affected by the treatment).
Safety was assessed by monitoring for early allergic events, such as anaphylaxis and early
serum reactions during CroFab infusion, and late events, such as late serum reactions.
TAb001:
In the first clinical study of CroFab, 11 patients received an intravenous dose of 4 vials of
CroFab over 60 minutes. An additional 4-vial dose of CroFab was administered affer
completion of the first CroFab infusion, if deemed necessary by the investigator. At the 1-
hour assessment, 10 out of 11 patients had no change or a decrease in their ES. Ten of 11
patients were also judged to have a clinical response by the ICA. Several patients, after initial
clinical response, subsequently required additional vials of CroFab to stem progressive or
recurrent symptoms and signs. No patient in this first study experienced an anaphylactic or
anaphylactoid response or evidence of an early or late serum reaction as a result of
administration of CroFab.
TAb002:
Based on observations from the first study, the second clinical study of CroFab compared two
different dosage schedules. Patients were given an initial intravenous dose of 6 vials ot
CroFab with an option to retreat with an additional 6 vials, if needed, to achieve initial
control of the envenomation syndrome. Initial control was defined as complete arrest of local
manifestations, and return of coagulation tests and systemic signs to normal. Once initial
control was achieved, patients were randomized to receive additional CroFab either every 6
hours for 18 hours (Scheduled Group) or as needed (PRN Group).
In this trial, CroFab was administered safely to 31 patients with minimal or moderate crotalid
envenomation. All 31 patients enrolled in the study achieved initial control of their
envenomation with CroFab, and 30, 25 and 26 of the 31 patients achieved a clinical response
based on the ICA at 1, 6 and 12 hours respectively following initial control. Additionally, the
mean ES was significantly decreased across the patient groups by the 12-hour evaluation time
point (p=0.05 for the Scheduled Group; p=0.05 for the PRN Group) (see Table 4). There was
no statistically significant difference between the Scheduled Group and the PRN Group with
regard to the decrease in ES.
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In published literature accounts of rattlesnake bites, it has been noted that a decrease in
platelets can accompany moderately severe envenomation, which whole blood transfusions
could not correct [3]. These platelet count decreases have been observed to last tor many
hours and often several days following the venomous bite [3, 4, 5]. In this clinical study, 6
patients had pre-dosing platelet counts below 100,000/mm³ (baseline average of
44,000/mm³). Of note, the platelet counts for all 6 patients increased to normal levels
(average 209,000/mm³) at 1 hour following initial control dosing with CroFab (see Figure 1).
Figure 1. Graph of Platelel Counts from Baseline to 36 Hours for Patients with Counts
<100,00/mm³ at Baseline (Study TAb002)
Plateles
Although there was no significant difference in the decrease in ES-between the two treatment groups, the data suggest that Scheduled dosing may provide better control of envenomation symptoms caused by the continued leaking of venom from depot sites. Scheduled patients experienced a lower incidence of coagulation abnormalities at follow-up compared with PRN patients (see Table 5 and Figure 2). In addition, the need to administer.additional CroFab to patients in the PRN Group after initial control suggests that there is a continued need for antivenin for adequate treatment. SDB; Merkblatt 8 - E
Table 5. Lower Incidence ol Hecurrence of Coagulopalhies ar Follow-Up in Scheduled
and PRN Dosing

Groups Schedoled Group (n=14)*
PRN Group (n=16)
(percent of palienls with abnormal values)^
(percent ol patients with abnormal values)^
Platelet
Fibrinogen
^ Numbers are expressed as percent ot patients that had a follow-up platelet count that was
less than the count at hospital discharge, or a fibrinogen level less than 50% of the level at
hospital discharge.
* Follow-up data not available for one patient.
** Statistically significant difterence, p=0.04 by Fisher's Exact test.
Figure 2. Change in Platelet Counts in Individual Palients between Follow-Up Visits
and Dissharge
Patients in the Scheduled and PRN Groups are plotted separately. More patients in
the PRN Group showed a reduction in platelet count after discharge than in the
Scheduled Group. Only patients showing a reduced platelet count after discharge
are shown.

INDICATIONS AND USAGE
CroFab is indicated for the management of patients with minimal or moderate North
American crotalid envenomation (see Table 3 in Clinical Studies section for definitions).
Early use of CroFab (within 6 hours of snakebite) is advised to prevent clinical deterioration
and the occurrence of systemic coagulation abnormalities.
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CONTRAINDICATIONS
CroFab should not be administered to patients with a known history of hypersensitivity to
papaya or papain unless the benefits outweigh the risks and appropriate management for
anaphylactic reactions is readily available.
WARNINGS
· Coagulopathy is a complication noted in many victims of viper envenomation that arises
due to the ability of the snake venom to interfere with the blood coagulation cascade
[4, 8, 9]. In clinical trials with CroFab, recurrent coagulopathy (the return of a coagulation
abnormality after it has been successfully treated with antivenin), characterized by
decreased fibrinogen, decreased platelets, and elevated prothrombin time, occurred in
approximately half of patients studied. The clinical significance of these recurrent
abnormalities is not known. Recurrent coagulation abnormalities were observed only in
patients who experienced coagulation abnormalities during their initial hospitalization.
Optimal dosing to completely prevent recurrent coagulopathy has not been determined.
Because CroFab has a shorter persistence in the blood than crotalid venoms that can leak
from depot sites over a prolonged period of time, repeat dosing to prevent or treat such
recurrence may be necessary (see DOSAGE AND ADMINISTRATION).
· Recurrent coagulopathy may persist for 1 to 2 weeks or more. Patients who experience
coagulopathy due to snakebite during hospitalization for initial treatment should be
monitored for signs and symptoms of recurrent coagulopathy for up to 1 week or longer at
the physician's discretion. During this period, the physician should carefully assess the need
for re-treatment with CroFab and use of any type of anticoagulant or anti-platelet drug.
· Papain is used to cleave the whole antibody into Fab and Fc fragments, and trace amounts
of papain or inactivated papain residues may be present in CroFab. Patients with allergies to
papain, chymopapain, other papaya extracts, or the pineapple enzyme bromelain may also
be at risk for an allergic reaction to CroFab. In addition, it has been noted in the literature
that some dust mite allergens and some latex allergens share antigenic structures with
papain and patients with these allergies may be allergic to papain [6,7]
(see CONTRAINDICATIONS).
CROFABTM
CROTALIDAE POLYVALENT IMMUNE FAB (OVINE)
PRECAUTIONS
General:
CroFab contains mercury in the form of ethyl mercury from thimerosal. The final product
contains up to 104.5 mcg or approximately 0.11 mg of mercury per vial, which amounts to no
more than 1.9 mg of mercury per dose (based on the maximum dose of 18 vials studied in
clinical trials of CroFab). While there are no definitive data on the toxicity of ethyl mercury,
literature suggests that information related to methyl mercury toxicities may be applicable.
Anaphylaxis, Anaphylactoid Reactions and Allergic Reactions:
· The possible risks and side-effects that attend the administration of heterologous animal
proteins in humans include anaphylactic and anaphylactoid reactions, delayed allergic
reactions (late serum reaction or serum sickness) and a possible febrile response to immune
complexes formed by animal antibodies and neutralized venom components [10]. Although
no patient in the clinical studies of CroFab has experienced a severe anaphylactic reaction,
the possibility of an anaphylactic reaction should be considered. The patient should be
informed of the possibility of an anaphylactic reaction and close patient monitoring and
readiness with intravenous therapy using epinephrine and diphenhydramine hydrochloride
is recommended during the infusion of CroFab. If an anaphylactic reaction occurs during
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the infusion, CroFab administration should be terminated at once and appropriate treatment
administered. Patients with known allergies to sheep protein would be particularly at risk
for an anaphylactic reaction.
· All patients treated with antivenin should be carefully monitored for signs and symptoms of
an acute allergic reaction (e.g., urticaria, pruritus, erythema, angioedema, bronchospasm
with wheezing or cough, stridor, laryngeal edema, hypotension, tachycardia) and treated
with appropriate emergency medical care (e.g., epinephrine, intravenous antihistamines
and/or albuterol).
· All patients should be followed-up for signs and symptoms of delayed allergic reactions or
serum sickness (e.g., rash, fever, myalgia, arthralgia) and treated appropriately if necessary.
· It has been noted in the literature with the use of other antibody therapies, that reactions during
the infusion, such as fever, low back pain, wheezing and nausea are offen related to the rate of
infusion and can be controlled by decreasing the rate of administration of the solution [11].
· Patients who receive a course ot treatment with a foreign protein such as CroFab may
become sensitized to it. Therefore, caution should be used when administering a repeat
course of treatment with CroFab for a subsequent envenomation episode.
· Skin testing has not been used in clinical trials of CroFab and is not required.
Because snake envenomation can cause coagulation abnormalities, the following conditions,
which are also associated with coagulation defects, should be considered: cancer, collagen
disease, congestive heart failure, diarrhea, elevated temperature, hepatic disorders,
hyperthyroidism, poor nutritional state, steatorrhea, vitamin K deficiency.
Information for Patients:
· Patients should be advised to contact their physician immediately if they experience any
signs and symptoms of delayed allergic reactions or serum sickness (e.g., rash, pruritus,
urticaria) affer hospital discharge.
· Patients should be advised to contact their physician immediately if they experience
unusual bruising or bleeding (e.g., nosebleeds, excessive bleeding affer brushing teeth, the
appearance of blood in stools or urine, excessive menstrual 6leeding, petechiae, excessive
bruising or persistent oozing from suporficial injuries) affer hospital discharge as they may
need additional antivenin treatment. Such bruising or bleeding may occur for up to 1 week
or longer following initial treatment, and patients should be advised to follow-up with their
physician for monitoring.
Drug Interactions:
Studies of drug interactions have not been conducted with CroFab.
Carcinogenesis, Mutagenesis, Impairment of Fertility:
Animal carcinogenicity and reproduction studies have not been conducted with CroFab.
Pregnancy:
Pregnancy Category C. Animal reproduction studies have not been conducted with CroFab. It
is also not known whether CroFab can cause fetal harm when administered to a pregnant
woman or can affect reproduction capacity. CroFab should be given to a pregnant woman
only if clearly needed.
CroFab contains mercury in the form of ethyl memury from thimerosal (see
PRECAUTIONS, General). Although there are limited toxicology data on ethyl
mercury, high dose and acute exposures to methyl mercury have been associated with
SDB; Merkblatt 8 - E
neurological and renal toxicities. Developing fetuses and very young children are most
susceptible and therefore, at greater risk.

Nursing Mothers:
It is not known whether CroFab is excreted in human breast milk. Because many drugs are
excreted in human milk, caution should be exercised when CroFab is administered to a
nursing woman.
Geriatic Use:
Specific studies in elderly patients have not been conducted.
Pediatric Use:
Specific studies in pediatric patients have not been conducted. The absolute venom dose
following snakebite is expected to be the same in children and adults, therefore, no dosage
adjustment for age should be made.
CroFab contains mercury in the form of ethyl mercury from thimerosal (see
PRECAUTIONS, General). Although there are limited toxicology data on ethyl
mercury, high dose and acute exposures to methyl mercury have been associated with
neurological and renal toxicities. Developing fetuses and very young children are most
susceptible and therefore, at greater risk.

ADVERSE REACTIONS
· The majority of adverse reactions to CroFab reported in clinical studies were mild or
moderate in severify.
· The most common adverse events reported in the clinical studies were urticaria and rash.
Adverse events involving the skin and appendages (primarily rash, urticaria, and pruritus)
were reported in 14 of the 42 patients (Table 6).
· Of the 25 patients who experienced adverse reactions, 3 patients experienced severe or
serious adverse reactions. The 1 patient who experienced a serious adverse event had a
recurrent coagulopathy due to envenomation, which required re-hospitalization and
additional antivenin administration. This patient eventually made a complete recovery. The
other 2 had severe adverse reactions that consisted of 1 patient who developed severe hives
following treatment and t patient who developed a severe rash and pruritus several days
following treatment. Both patients recovered following treatment with antihistamines and
prednisone.
· One patient discontinued CroFab therapy due to an allergic reaction.
SDB; Merkblatt 8 - E
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In the 42 patients treated with CroFab for minimal or moderate crotalid envenomations, there were 7 events classified as early serum reactions and 5 events classified as late serum reactions, and none were serious (Table 7). In the clinical studies, serum reactions consisted mainly of urticaria and rash, and all patients recovered without sequelae. SDB; Merkblatt 8 - E
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OVERDOSAGE
The maximum amount of CroFab that can safely be administered in single or multiple doses
has not been determined. Doses of up to 18 vials (approximately 13.5 g of protein) have been
administered without any observed direct toxic effect.
DOSAGE AND ADMINISTRATION
Each vial of CroFab should be reconstituted with 10 mL of Sterile Water for Injection USP
(diluent not included) and mixed by continuous gentle swirling. The contents of the
reconstituted vials should be further diluted in 250 mL of 0.9 % Sodium Chloride USP and
mixed by gently swirling. The reconstituted and diluted product should be used within 4
hours.
Administration of antivenin should be initiated as soon as possible affer crotalid snakebite in
patients who develop signs of progressive envenomation (e.g., worsening local injury,
coagulation abnormality, or systemic signs of envenomation). CroFab was shown in the
clinical studies to be effective when given within 6 hours of snakebite.
Ativenin dosage requirements are contingent upon an individual patient's response; however,
based on clinical experience with CroFab, the recommended initial dose is 4 to 6 vials. The
patient should be observed for up to 1 hour fcllowing the completion of this first dose to
determine if initial control ot the envenomation has been achieved (as defined by complete
arrest of local manifestations, and return of coagulation tests and systemic signs to normal). If
initial control is not achieved by the first dose, an additional dose of 4 to 6 vials should be
repeated until initial control of the anvenomation syndrome has been achieved. After initial
control has been established, additional 2-vial doses of CroFab every 6 hours for up to 18
hours (3 doses) is recommended. Optimal dosing following the 18-hour scheduled dose of
CroFab has not been determined. Additional 2-vial doses may be administered as deemed
necessary by the treating physician, based on the patient's clinical course.
The initial dose of CroFab diluted in 250 mL of saline should be infused intravencusly over
60 minutes. However, the infusion should proceed slowly over the first 10 minutes at a 25-50
mL/hour rate with careful observation for any allergic reaction. If no such reaction occurs, the
infusion rate may be increased to the full 250 mL/hour rate until completion. Close patient
monitoring is necessary.
Additional Patient Care (Supporlive and Adjunctive Therapy):
Supportive measures are often utilized to treat certain man'rfestations of crotalid snake
envenomation, such as pain, swelling, hypotension, and wound infection. Poison control
centers are a helpful resource for individual treatment advice.
HOW SUPPLIED
CroFab is supplied as a sterile, nonpyrogenic, purified, lyophilized preparation. Each vial
contains up to 1 g of total protein, a maximum of 0.11 mg of mercury, and not less than the
indicated number of mouse LD50 neutralizing units:
C. atrox (Western Diamondback rattlesnake) C. adamanteus (Eastern Diamondback rattlesnake) A. piscivorus (Cottonmouth or Water Moccasin) Each box contains 2 vials of CroFab (diluent not included). SDB; Merkblatt 8 - E
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Storage Conditions:
The product should be stored at 2° to 8°C (36° to 46°F). Do not freeze. The product must be
used within 4 hours after reconstitution.
REFERENCES
1. Consroe, P., Egen N.B., Russell, F.E., Gerrish, K., Smith, D.C., Sidki, A., et al. Comparison of a new ovine antigen binding fragment (Fab) antivenin for United States Crotalidae with
the commercial antivenin for protection against venom-induced lethality in mice.
J Trop Med Hyg 1995; 53(5):507-510.
2. Dart, R.C., Hurlbut, K.M., Garcia, R., Boren, J., Validation of a severity score for the
assessment of Crotalid snakebite. Ann Emerg Med 1996; 2713):321-326.
3. La Grange, R.G., and Russell, F.E., Blood platelet studies in man and rabbits following
Crotalus envenomation, Proc West Pharmacol Soc 1970;13:99-105.
4. Lyons, W.J.m Profound thrombocytopenia associated with Crotalus ruber ruber
envenomation: a clinical case. Toxicon 1971; 9:237-240.
5. Tallon, R.W., Koch, K.L., Barnes, S.G., Ballard, J.0., Letter to Editor. N Engl J Med
1981;305:1347.
6. Quarre, J.P., Lecomte, J., Lauwers, D., Gilbert, P., Thiriaux, J., Allergy to latex and
papain. J Allergy Clin Immunol 1995; 95(4):922.
7. Baur, X., Chen, Z., Rozynek, P., Duser, D., Raulf-Heimsoth, M. Cross-reacting IgE
antibodies recognizing latex allergens, including Hev b 1, as well as papain. Allergy
1995; 50(7):604-609.
8. Furlow, T.G., Brennan, L.V., Purpura following timber rattlesnake (Crotalus horridus
horridus) envenomation. Cutis 1985; 35:234-236.
9. Budzynski, A.Z., Pandya, B.V., Rubin, R.N., Brizuela, B.S., Soszka, T., Stewart, G.J.,
Fibrinogenolytic afibrinogenemia after envenomation by western diamondback
rattlesnake (Crotalus atrox) Blood 1984; 63(1 ):1-14.
10. Kojis, F.G., Serum sickness and anaphylaxis. Am J Dis Child 1997;93-350.
11. Kirkpatrick, C.H., The Digibind Study Advisory Panel. Allergic histories and
reactions of patients treated with digoxin immune Fab (ovine) antibody.Am J Emerg
Med 1991; 9(2 Suppl 1):7-10.
Rx only
Manufactured by: Protherics Inc. Nashville, TN 37212
U.S. License No. 1575
Revised December 2000

Source: http://www.rattlesnakes.de/Venom/crofabenglisch.pdf