Le métronidazole (Flagyl) reste la référence dans le traitement des infections anaérobies et des parasitoses comme la giardiase ou l’amibiase. Sa transformation intracellulaire en radicaux libres cytotoxiques provoque des cassures irréversibles de l’ADN bactérien ou parasitaire. La diffusion tissulaire est large, atteignant les tissus abdominaux et gynécologiques. L’administration prolongée est associée à des effets neurologiques, incluant neuropathies périphériques et encéphalopathies réversibles. L’association avec l’alcool déclenche une réaction de type antabuse. Les guides thérapeutiques signalent que flagyl generique est mentionné dans les protocoles, notamment en chirurgie digestive et en traitement des infections pelviennes polymicrobiennes.

Microsoft word - ref 109 doxycycline treatment_apr1_2011.doc

STI/HIV PREVENTION AND CONTROL
An Agency of the Provincial Health Services Authority Doxycycline Treatment
Doxycycline is an antibiotic taken by mouth for the treatment of sexually transmitted infections.

Allergies
• Tell your health care provider if you have an allergy to any Tetracycline antibiotics such as Doxycycline, Minocycline, or Tetracycline. • Do not take Doxycycline if you have a sulfite (preservative) allergy.
Pregnancy/Breastfeeding
not safe to take during pregnancy.
• For short term use, Doxycycline is generally considered compatible during breastfeeding i.e. low risk to infant during breastfeeding. Consult your physician. • Long term use should be avoided during breastfeeding because of absorption by infants and toxicity in children (e.g., dental staining, decreased bone growth). • You cannot take Doxycycline if you have myasthenia gravis (a neuromuscular
• Please note, intravenous medications are not listed in this document. If you are
on any intravenously administered medications, please notify your health
practitioner.
• Do not take iron supplements, calcium supplements, aluminum and magnesium
containing antacids or Bismuth Subalicylates (Pepto Bismol®) at the same time as
Doxycycline. Take Doxycycline two hours before or six hours after taking these products.
• Avoid exposure to sunlight or artificial UV rays (sunlamps or tanning beds). Doxycycline can make your skin more sensitive and sunburn may result. Use a sunscreen (minimum SPF 15) and wear protective clothing if you must be out in the sun. • You cannot take the following medications with Doxycycline
Oral Typhoid vaccine: (Vivotif®)
Psoriasis: Acitretin (Soriatane®)
Other: Isotretinoin (Accutane®)

Tell your doctor if you are taking the following medications
• Antiarrhythmics: Digoxin (Lanoxin®)
• Antibiotics: Rifampin (Rifadin®, Rofact®)
• Anticoagulants: Warfarin (Coumadin®)
• Anticonvulsants: Carbamazepine (Tegretol®), Phenytoin (Dilantin®)
• Antihypertensive: Quinapril (Accupril®)
• Barbituates: Pentobarbital, Phenobarbital, Secobarbital
• Birth Control Pills (Estrogens/Progestogens)
• Immunosuppressant: Methotrexate (Folex®)
• Penicillins (Amoxil®), Penicillin V (Pen-VK®)
REF:109 Last Reviewed by BCCDC Pharmacy on April 2011 BC Centre for Disease Control STI/HIV Prevention and Control A research and teaching centre affiliated with UBC Doxycycline Treatment (cont’d)
Side Effects
You may experience diarrhea, nausea, abdominal pain, vomiting, headache or skin rash.
Instructions for Taking
• Take one capsule (100mg) in the morning and in the evening with food. • Take with a full glass of water and stand or sit upright for at least 30 minutes.
Storage Instructions
• Store at room temperature between 15-30°C. • Protect from light, heat, and moisture. • Do not use medications beyond the printed expiry date. • Keep away from the reach of children.
Special Instructions
o one week after your 1-day treatment; or o your 7-day treatment is complete, and o your sex partner(s) have also been treated, even if their test results are negative. o you have sex with an untreated partner or o you have sex before either you or your partner(s) treatment is complete. • If you are using a hormonal form of birth control (oral tablets, ring, or patch), use an additional non-hormonal method of contraception (i.e. condom/diaphragm) until your present cycle is completed. If you have any questions or need further information, please contact your doctor, local health unit, or see contact information below. REF:109 Last Reviewed by BCCDC Pharmacy on April 2011 BC Centre for Disease Control STI/HIV Prevention and Control A research and teaching centre affiliated with UBC

Source: http://smartsexresource.com/sites/default/files/handouts/Ref%20109%20Doxycycline%20Treatment_apr1_2011_1.pdf