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Read this Patient Information before you start taking STENDRA and each time you get a refill. There may be new
information. This information does not take the place of talking with your healthcare provider about your medical
condition or your treatment.
What is the most important information I should know about STENDRA?
STENDRA can cause your blood pressure to drop suddenly to an unsafe level if it is taken with certain other
Do not take STENDRA if you take any medicines called “nitrates.” Nitrates are used to treat chest pain
(angina). A sudden drop in blood pressure can cause you to feel dizzy, faint, or have a heart attack or stroke.
Tell all your healthcare providers that you take STENDRA.
If you need emergency medical care for a heart problem,
it will be important for your healthcare provider to know when you last took STENDRA.
Stop sexual activity and get medical help right away if you get symptoms such as chest pain, dizziness, or nausea during
sex. Sexual activity can put an extra strain on your heart, especially if your heart is already weak from a heart attack or
What is STENDRA?
STENDRA is a prescription medicine used to treat erectile dysfunction (ED).
STENDRA is not for use in women or children.
It is not known if STENDRA is safe and effective in women or children under 18 years of age. Who should not take STENDRA?
Do not take STENDRA if you:
• take medicines called “nitrates” • use street drugs called “poppers” such as amyl nitrate and butyl nitrate • are allergic to avanafil or any of the ingredients in STENDRA. See the end of this leaflet for a complete list of
What should I tell my healthcare provider before taking STENDRA?
Before you take STENDRA, tell your healthcare provider if you:
• have or have had heart problems such as a heart attack, irregular heartbeat, angina, or heart failure • have had heart surgery within the last 6 months • have had a stroke • have low blood pressure, or high blood pressure that is not controlled • have a deformed penis shape • have had an erection that lasted for more than 4 hours • have problems with your blood cells such as sickle cell anemia, multiple myeloma, or leukemia • have retinitis pigmentosa, a rare genetic (runs in families) eye disease
• have ever had severe vision loss, including an eye problem called non-arteritic anterior ischemic optic neuropathy
• have bleeding problems • have or have had stomach ulcers • have liver problems • have kidney problems or are having kidney dialysis • have any other medical conditions
Tell your healthcare provider about all the medicines you take
, including prescription and non-prescription medicines,
vitamins, and herbal supplements.
STENDRA may affect the way other medicines work, and other medicines may affect the way STENDRA works causing side effects. Especially tell your healthcare provider if you take any of the following:
• medicines called nitrates (s) • medicines called HIV protease inhibitors, such as ritonavir (Norvir), indinavir (Crixivan), saquinavir (Fortavase
• some types of oral antifungal medicines, such as ketoconazole (Nizoral), and itraconozale (Sporonox) • some types of antibiotics, such as clarithromycin (Biaxin), telithromycin (Ketek), or erythromycin • medicines called alpha blockers. These include Hytrin (terazosin), Flomax (tamsulosin HCl), Cardura
(doxazosin), Minipress (prazosin HCl), Uroxatral (alfuzosin HCl), Jalyn (dutasteride and tamsulosin HCl), or Rapaflo (silodosin). Alpha-blockers are sometimes prescribed for prostate problems or high blood pressure. In some patients, the use of STENDRA with alpha-blockers can lead to a drop in blood pressure or to fainting.
• other medicines that treat high blood pressure • other medicines or treatments for ED
Ask your healthcare provider or pharmacist for a list of these medicines, if you are not sure.
Know the medicines you take. Keep a list of them to show to your healthcare provider and pharmacist when you get a
How should I take STENDRA?
• Take STENDRA exactly as your healthcare provider tells you to take it.
• Your healthcare provider will tell you how much STENDRA to take and when to take it.
• Take STENDRA about 30 minutes before sexual activity.
• Do not
take STENDRA more than 1 time a day.
• Your healthcare provider may change your dose if needed.
• You should take the lowest dose of STENDRA that works for you. You and your healthcare provider should decide
about the lowest dose of STENDRA that works for you.
• STENDRA may be taken with or without food.
• Do not
drink too much alcohol when taking STENDRA (for example, 3 glasses of wine, or 3 shots of whiskey).
Drinking too much alcohol when taking STENDRA can increase your chances of getting a headache or getting dizzy, increasing your heart rate, or lowering your blood pressure.
What are the possible side effects of STENDRA?
The most common side effects of STENDRA are:
• headache • flushing • stuffy or runny nose • sore throat • back pain
STENDRA may uncommonly cause:
• an erection that will not go away (priapism).
If you have an erection that lasts more than 4 hours, get medical help
• sudden vision loss in 1 or both eyes.
Sudden vision loss in 1 or both eyes can be a sign of a serious eye problem
called non-arteritic anterior ischemic optic neuropathy (NAION). Stop taking STENDRA and call your healthcare provider right away if you have sudden vision loss in 1 or both eyes.
• sudden hearing decrease or hearing loss.
Some people may also have ringing in their ears (tinnitus) or dizziness.
Tell your healthcare provider if you have any side effect that bothers you or does not go away.
These are not all the possible side effects of STENDRA. For more information, ask your healthcare provider or pharmacist.
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
How should I store STENDRA?
• Store STENDRA at 68°F to 77°F (20°C to 25°C). • Keep STENDRA out of the light.
Keep STENDRA and all medicines out of the reach of children
General information about the safe and effective use of STENDRA.
Medicines are sometimes prescribed for purposes other than those listed in a Patient Information leaflet. Do not use STENDRA for a condition for which it was not prescribed. Do not give STENDRA to other people, even if they have the same symptoms that you have. It may harm them.
This Patient Information leaflet summarizes the most important information about STENDRA. If you would like more information, talk with your healthcare provider. You can ask your healthcare provider or pharmacist for information about STENDRA that is written for health professionals.
For more information, go to www.STENDRA.com or call 1-877-663-0412.
What are the ingredients in STENDRA?
mannitol, fumaric acid, hydroxypropylcellulose, low substituted hydroxypropylcellulose, calcium
carbonate, magnesium stearate, and ferric oxide yellow
This Patient Information has been approved by the U.S. Food and Drug Administration.
Norvir (ritonavir) is a trademark of Abbott Laboratories
Crixivan (indinavir sulfate) is a trademark of Merck Sharp & Dohme Corp.
Invirase (saquinavir mesylate) is a trademark of Hoffmann-LA Roche, Inc.
Reyataz (atazanavir sulfate) is a trademark of Bristol-Myers Squibb Co.
Biaxin (clarithromycin) is a trademark of Abbott Laboratories
Ketek (telithromycin) is a trademark of Aventis Pharma S.A.
Nizoral (ketoconazole) is a trademark of Johnson & Johnson
Sporanox (itraconazole) is a trademark of Johnson & Johnson
Hytrin (terazosin HCl) is a trademark of Abbott Laboratories
Flomax (tamsulosin HCl) is a trademark of Yamanouchi Pharmaceutical Co., Ltd.
Cardura (doxazosin mesylate) is a trademark of Pfizer Inc.
Minipress (prazosin HCl) is a trademark of Pfizer Inc.
Uroxatral (alfuzosin HCl) is a trademark of Sanofi Societi Anonyme France
Jalyn (dutasteride and tamsulosin HCl) is a trademark of Glaxo Group Limited
Rapaflo (silodosin) is a trademark of Watson Pharmaceuticals, Inc.
Manufactured for: VIVUS, Inc.
Mountain View, CA 94041
Manufactured in Osaka Japan
Distributed by: Auxilium Pharmaceuticals, Inc.
Chesterbrook, PA 19087
is a registered trademark of VIVUS, Inc.
2012-2014, VIVUS, Inc. All rights reserved.
US Patent Number: 6,656,935 and 7,501,409
STENDRA is a registered U.S. trademark of VIVUS, Inc. 2012 - 2014, VIVUS, Inc.
HIGHLIGHTS OF PRESCRIBING INFORMATION
FULL PRESCRIBING INFORMATION: CONTENTS*
5.2 Concomitant Use of CYP3A4 Inhibitors
5.6 Alpha-Blockers and Other Antihypertensives
5.8 Combination with Other PDE5 Inhibitors or Erectile Dysfunction Therapies
5.10 Counseling Patients about Sexually Transmitted Diseases
7.1 Potential for Pharmacodynamic Interactions with STENDRA
7.2 Potential for Other Drugs to Affect STENDRA
7.3 Potential for STENDRA to Affect Other Drugs
13.1 Carcinogenesis, Mutagenesis and Impairment of Fertility
13.2 Animal Toxicology and/or Pharmacology
16 HOW SUPPLIED/STORAGE AND HANDLING
17.2 Cardiovascular Considerations
17.3 Concomitant Use with Drugs Which Lower Blood Pressure
17.4 Potential for Drug Interactions
17.9 Sexually Transmitted Disease
17.10 Recommended Administration
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