Italiano Farmacia on line: comprare cialis senza ricetta, acquistare viagra internet.
Detailed Guide: Waldenstrom's Macroglobulinemia
What Is Waldenstrom Macroglobulinemia?
Waldenstrom macroglobulinemia is a type of non-Hodgkin lymphoma (see the American Cancer
Society document on non-Hodgkin lymphoma) that produces large amounts of an abnormal
protein (called a macroglobulin). Having too much of this abnormal protein causes many of the
symptoms associated with this condition.
The lymphoma cells grow mainly in the bone marrow but can grow in other organs such as the
liver and the spleen. The lymphoma cells can crowd out the normal blood-producing cells of the
bone marrow. This can cause other symptoms, due to low blood counts. Waldenstrom
macroglobulinemia is named after Jan Waldenstrom, the Swedish doctor who first recognized this
condition in 1944. Although this is a type of lymphoma, most doctors call it Waldenstrom
macroglobulinemia. Lymphoid Tissue and the Immune System
Lymphoid tissue is formed by several types of immune system cells that work together to resist
infections. Lymphoid tissue also reacts to transplanted tissues (such as blood transfusions or
organ transplants) from other people and is involved in fighting some types of cancer.
Lymphoid tissue is found in lymph nodes,
which are pea-sized collections of immune system
cells found in the underarm area, in the groin, on the sides of the neck, inside the chest, and
inside the abdomen. Lymphoid tissue is found in the bone marrow, as well as other organs such
as the thymus (found behind the chest bone and in front of the heart), the spleen (on the left side
of the abdomen next to the stomach), and the tonsils and adenoids. Lymphoid tissue is also
scattered throughout the body within other systems such as the digestive system and respiratory
Waldenstrom macroglobulinemia is a cancer of the B lymphocytes (lymph cells). Lymphocytes
(lymph cells) are the main cell type of the immune system and of lymphoid tissue. There are 2
types of lymphocytes: T cells
and B cells
. When B cells respond to an infection, they mature and
change from round-shaped lymphocytes into oval-shaped plasma cells. As this change occurs,
the cells begin to produce and release proteins called immunoglobins
(antibodies) to attack and
help kill disease-causing germs such as bacteria. T cells mainly help direct the immune
response but also can directly kill invading infections. Cells Responsible for Waldenstrom Macroglobulinemia
The cancer cells in people with Waldenstrom macroglobulinemia have some similarities to those
of 2 other types of cancer: multiple myeloma and non-Hodgkin lymphoma. Multiple myeloma is
considered a cancer of plasma cells and non-Hodgkin lymphoma is a cancer of lymphocytes. The
cells of Waldenstrom macroglobulinemia are often described as lymphoplasmacytoid, meaning
that they have features of both plasma cells and lymphocytes. These cells produce large amounts
of an abnormal type of antibody protein (immunoglobulin M, or IgM) that causes most of the
symptoms of Waldenstrom macroglobulinemia, including excessive bleeding, problems with
vision, and nervous system problems.
Revised: 03/01/2004 What Are the Key Statistics About Waldenstrom Macroglobulinemia?
There are no exact statistics about this disease. It is estimated that about 1,000 to 1,500 people
are diagnosed with Waldenstrom macroglobulinemia each year in the United States. There is no
firm evidence that this number has either increased or decreased in the last few years.
The chance of developing this disease increases with age. In one large group of patients, half
were over the age of 67. It is exceptionally rare in people under age 50, but Waldenstrom
macroglobulinemia has been seen in patients as young as 27. White males develop this cancer
twice as often as black males or white or black females.
The average survival of people with Waldenstrom macroglobulinemia is about 7 to 9 years
according to various experts. Younger patients generally live longer. In one study the average
survival of those under age 65 was over 14 years. Those over 65 had an average survival of 7
years. Survival is shorter if there is extensive disease. It is important to know that these numbers
come from patients treated many years ago. Newer treatments have been developed and the
survival rate may be better now.
Revised: 03/01/2004 What Are The Risk Factors For Waldenstrom Macroglobulinemia?
A risk factor
is anything that increases a person's chance of getting a disease. Different cancers
have different risk factors. For example, unprotected exposure to strong sunlight is a risk factor for
skin cancer. Smoking is a risk factor for cancers of the lung, mouth, larynx, bladder, kidney, and
several other organs.
Researchers have found few risk factors that make a person more likely to develop Waldenstrom
macroglobulinemia. However, most people with these risk factors never develop the disease.
Even if a patient with Waldenstrom macroglobulinemia does have one or more risk factors, it is
impossible to know for sure how much that risk factor contributed to causing the cancer. Monoclonal Gammopathy of Undetermined Significance (MGUS):
Monoclonal gammopathy of
undetermined significance (MGUS), which is found with a special blood test, is an abnormality of
antibody-producing cells that is related to multiple myeloma and Waldenstrom
macroglobulinemia. In MGUS, there is also too much production of an antibody protein
(immunoglobulin) by abnormal plasma cells, or "lymphoplasmacytoid" cells. However, these
abnormal cells do not form an actual tumor or mass and do not cause any symptoms. MGUS
usually has no impact on a person's health. But, about 20% of people with MGUS will develop
multiple myeloma or non-Hodgkin lymphoma within 20 years. Most of these cases of non-Hodgkin
lymphoma involve cancer cells with "lymphoplasmacytoid" features. Aging:
Age is among the most significant risk factor. This disease is rare among people younger
than 50 years old. Race:
Waldenstrom macroglobulinemia is more common among whites than among African
Americans. This is the opposite of the situation for multiple myeloma, which is about twice as
common among African Americans as white Americans. The reasons for these differences are
Men are more likely to develop this disease than are women. Heredity:
Genetic factors may play a role. In one study, about 20% of patients with Waldenstrom
macroglobulinemia had a close relative with another type of lymphoma or Waldenstrom
How Is Waldenstrom Macroglobulinemia Staged?
There is no standard staging system for Waldenstrom macroglobulinemia as there is for most
other cancers. This means that the usual staging studies such as imaging tests are not as
important in this disease. The diagnosis of Waldenstrom macroglobulinemia is made by finding
the abnormal protein in the blood and the typical lymphoplasmacytoid lymphoma cells in the bone
marrow. Doctors look at the degree of anemia, the amount of immunoglobulin in the blood and,
most importantly, a protein in the blood called beta-2-macroglubulin. People with a level of beta-2-
macroglobulin below 3 mg/L (milligrams per liter) live 2 to 3 times longer than those whose level
is above 3. Patients with Waldenstrom macroglobulinemia who are anemic or have a low blood
platelet count also have a shorter survival. Being older also leads to a poorer outlook.
In one study, people with none of these unfavorable signs had an average survival of 14 years.
People with all of them lived, on average, only about 4 years.
How Is Waldenstrom Macroglobulinemia Treated?
This information represents the views of the doctors and nurses serving on the American Cancer
Society's Cancer Information Database Editorial Board. These views are based on their
interpretation of studies published in medical journals, as well as their own professional
The treatment information in this document is not official policy of the Society and is not intended
as medical advice to replace the expertise and judgment of your cancer care team. It is intended to
help you and your family make informed decisions, together with your doctor.
Your doctor may have reasons for suggesting a treatment plan different from these general
treatment options. Don't hesitate to ask him or her questions about your treatment options.
In recent years, some progress has been made in treating people with Waldenstrom
macroglobulinemia. It is important to understand all treatment options. It is often a good idea to
seek a second opinion, since it can provide additional information and help the patient feel more
confident about the treatment plan that is chosen.
Revised: 03/01/2004 Systemic Chemotherapy
Chemotherapy uses anticancer drugs that are injected into a vein or a muscle, or are taken by
mouth. These drugs enter the bloodstream and reach all areas of the body (that is why it is called "systemic"), making this treatment very useful for lymphoma. There are many drugs that are useful in the treatment of patients with lymphoma and Waldenstrom macroglobulinemia. The most commonly used drugs have been chlorambucil (Leukeran) and prednisone, given together. Other chemotherapy drugs are cyclophosphamide (Cytoxan) and doxorubicin (Adriamycin). Recently, doctors have begun to favor the drugs fludarabine (Fludara) and cladribine (Leustatin). These are given intravenously for several days at a time. Sometimes, several drugs are combined. Most of these chemotherapy treatments are given on an outpatient basis (in the doctor's office or clinic or hospital outpatient department), but some require hospital admission. Sometimes a patient may take one chemotherapy combination for several cycles and later be switched to a different one if the first treatment combination does not seem to be working effectively. This is usually determined after retesting blood samples for IgM levels, by physical examination (for example, if an enlarged lymph node hasn't shrunk), or by imaging tests (for example, CT or MRI scans indicate that internal organs or lymph nodes inside the body have not shrunk).
Chemotherapy drugs are intended to kill lymphoma cells but they can also damage normal cells. For this reason, some side effects occur. Side effects depend on the type and dose of drugs given and the length of time they are taken. Drugs used in cancer chemotherapy specifically attack cells that are rapidly dividing. These drugs are useful because cancer cells spend more of their time dividing and reproducing than normal cells do. There are some normal tissues such as the bone marrow, the lining of the mouth and intestines, and the hair follicles that also grow rapidly to replace cells that wear out. These rapidly growing normal cells are the ones most likely to be adversely affected by chemotherapy. As a result, a patient may have hair loss, mouth sores, lowered resistance to infection due to low white blood cell counts, and easy bruising and bleeding due to low platelet counts. Loss of appetite, nausea, and vomiting result in part from damage to intestinal cells. The effects of certain drugs on areas of the brain controlling appetite also contribute to these problems. The doctor will try to avoid them with special drugs that are designed to overcome some of these side effects. For example, drugs can be given along with the chemotherapy to prevent or reduce nausea and vomiting. He or she will also discuss what the patient can do to lessen the side effects. These side effects are temporary and go away after treatment is finished. Some chemotherapy drugs also have side effects that are not related to their effects on rapidly dividing cells. Organs that could be directly damaged by these chemotherapy drugs include the kidneys, liver, testes, ovaries, brain, heart, and lungs. With careful monitoring, such side effects are rare. If serious side effects occur, the chemotherapy may have to be reduced or stopped, at least temporarily. Careful monitoring and adjustment of drug doses is important because some side effects to organs are permanent. One of the most serious late complications of successful chemotherapy is the possibility of developing leukemia. This affects a small percentage of patients. Revised: 03/01/2004
Biological Therapy or Immunotherapy
Biological therapies use naturally occurring substances produced by the immune system. These
substances may kill lymphoma cells, slow their growth, or may activate the patient's immune
system to more effectively fight the lymphoma. Interferon:
Interferon is a hormone-like protein naturally produced by white blood cells to help the
immune system fight infections. Some studies have suggested that interferon can cause tumors
of some lymphomas to shrink. Side effects of this treatment include moderate to severe fatigue,
fever, chills, headaches, muscle and joint aches, and mood changes. It is still not certain whether
interferon is the best treatment for some patients who have non-Hodgkin lymphoma with
Waldenstrom macroglobulinemia. It is usually used only in patients who continue to get sicker
after treatment with standard chemotherapy drugs. Immunotherapy with monoclonal antibodies:
Antibodies are normally produced by the immune
system to help fight infections. Similar antibodies called monoclonal antibodies
can be made in
the laboratory. Instead of attacking germs as usual antibodies do, some monoclonal antibodies
can be designed to attack lymphoma cells. After years of laboratory research, several monoclonal
antibodies are now being tested in clinical trials as treatments for non-Hodgkin lymphoma.
The most widely used monoclonal antibody is rituximab (Rituxan). Rituximab specifically
recognizes and attaches to a substance called CD20 that is found on the surface of the lymphoma
cells responsible for Waldenstrom macroglobulinemia. This attachment seems to cause the
lymphoma cell to die. Patients receive intravenous (in a vein) infusions once a week for 4
treatments. The treatments can be given in the oncologist's office or clinic. Common side effects
include chills, fever, nausea, rashes, fatigue, and headaches. Although more serious side effects
rarely occur, side effects similar to those seen during chemotherapy do not occur. This treatment
has generally been used for patients whose lymphoma either has not responded to
chemotherapy or has come back. Many doctors are now using monoclonal antibodies together
with chemotherapy for the initial treatment of people with Waldenstrom macroglobulinemia.
A second monoclonal antibody, called alemtuzumab (Campath), has also helped patients with
Waldenstrom macroglobulinemia when they stopped responding to other treatments. Thalidomide:
Thalidomide is a drug that has been useful in treating multiple myeloma. A small
number of patients with Waldenstrom macroglobulinemia have improved with thalidomide
treatment. Many have stopped the drug because of its side effects of drowsiness, fatigue, severe
constipation, and sometimes, nerve damage. New drugs that work like thalidomide but without the
side effects are being developed. Bortezomib (Velcade):
This newly approved drug has also been useful in people whose disease
has stopped responding to other drugs.
The cost of the biological medicines is very high, even with a good insurance company. Changes
in recent laws require that patients pay for 20% of their medicine as copayment. If your medicine
costs thousands of dollars, this becomes quite expensive, unless you have health insurance that
fully covers the cost. Be sure to check with your health insurance company before deciding to take
these kinds of treatments.
This treatment is used to lower the viscosity ("thickness") of the blood. Blood is removed from a
vein and the plasma
(liquid part of the blood) is separated from the blood cells. The blood cells
are mixed with salt solution and given back to the patient. The plasma containing the abnormal
protein is discarded. Often this is done continuously with a cell separator device, but if the blood is
too viscous, it may need to be done manually by removing a single pint of blood at a time. Each
plasmapheresis treatment takes a few hours.
Plasmapheresis is very helpful in relieving symptoms of newly diagnosed patients (while
chemotherapy is starting to work) and for those whose Waldenstrom macroglobulinemia is not
controlled by chemotherapy, biological therapy, or other treatments. When patients have
symptoms from elevated IgM, they need to have plasmapheresis right away to prevent
Stem Cell Transplantation (SCT)
This is a treatment that is still being studied and should be done as part of a clinical trial.
There are 2 main methods of SCT: allogeneic
. In an allogeneic stem cell
, the donor and patient are matched by certain basic cell characteristics that are
inherited. Usually the donor is a brother or sister. If there is no sibling that can be matched, an
unrelated donor may also be matched. The blood-forming stem cells can be taken from several
bone marrow aspirates or they can be separated from the peripheral (circulating) blood by a
method known as apheresis.
Recent studies have shown that there may be an advantage to using
blood-forming stem cells obtained by apheresis instead of bone marrow aspiration. This has
become the usual way to obtain these. Al ogeneic transplantation has limited usefulness due to the need for a matched donor. Another limitation is that side effects of this treatment are too severe for most people older than 50 years old. In an autologous stem cell transplant
, a patient's own blood-forming stem cells are removed from his bloodstream. This is usually done after the patient has received treatment that destroys as much as possible of the Waldenstrom macroglobulinemia cells. Blood-forming stem cells collected from a donor or the patient are carefully frozen and stored. The patient then receives high-dose chemotherapy and sometimes whole body radiation treatment as well. This destroys remaining cancer cells, but it also kills all or most normal cells in the bone marrow. After therapy, the frozen stem cells are thawed and returned to the body in a blood transfusion. A radiation oncologist will see the patient before the stem cell transplant is done and will take measurements of the patient so that radiation shields can be built to protect the lungs, heart, and kidneys from damage during high-dose, whole body radiation therapy. The patient having a stem cell transplant may be admitted to the hospital transplant unit or receive treatment as an outpatient depending on a variety of factors. If done as an outpatient, patients and families need to be able to identify early complications requiring their doctor's attention. Unless they live close to the transplant center, they will be asked to stay in a nearby hotel. After the patient and family are educated about the process and complications, the patient starts high-dose chemotherapy and may be given high-dose whole body radiation. Next, the patient's own stem cells (autologous), or a matched donor's stem cells (allogeneic), are given through a vein or venous access line. Even though the cells are given into a vein, they will eventually settle into the bone marrow where they will begin to grow. Then the waiting period begins. Patients who receive a donor's stem cells are given antirejection drugs (such as prednisone or cyclosporine). For the next 3 to 4 weeks the patient is given as much supportive therapy as needed. This can include intravenous nutrition, antibacterial, antiviral, and antifungal antibiotics, red blood cell transfusions, platelet transfusions, or other medications as needed. Usually around 14 to 21 days after the stem cells have been infused, they begin producing white blood cells. This is followed by the production of platelets and, several weeks later, red blood cells. Patients are kept in protective isolation until their white blood cell count rises above 500. They can usually leave the hospital when their white blood cell count nears 1,000. The patient is then examined in the outpatient clinic almost every day for several weeks. Patients typically make regular visits to the outpatient transplantation clinic for about 6 months, after which time their care is continued by their oncologist or internist. At this point they only come back to the bone marrow transplant clinic for their annual exam. If they have symptoms, these should be brought to the attention of their doctor. Bone marrow or peripheral blood stem cell transplant is still a complex treatment. If the doctors think the patient may benefit from transplantation, the best place to have it done is at a nationally recognized cancer center where the staff has experience with the procedure and with managing the recovery period. Patients should not hesitate to ask the doctor about the number of times he or she has done this procedure and how patients responded to the treatment. Experience and knowledge are key factors in providing the best care.
Bone marrow transplantation is very expensive (more than $100,000) and can require a lengthy hospital stay. Some insurance companies view this procedure as experimental and may not pay for it. Because there are fewer complications with autologous (stem cells from the patient) transplants than with allogeneic (stem cells from a matched donor), they are usually less expensive. Side effects from a stem cell transplant are generally divided into early and long-term effects. The early complications and side effects are basically the same as those caused by any other type of high-dose chemotherapy. They are caused by damage to the bone marrow and other rapidly growing tissues of the body. Complications and side effects that can persist for a long time or not occur until years after the transplant include: ▪ Radiation damage to the lungs, causing shortness of breath ▪ Graft-versus-host disease, which occurs only in allogeneic (donor) transplants (see below) ▪ Damage to the ovaries that can cause infertility and loss of menstrual periods ▪ Damage to the thyroid gland that can cause problems with metabolism ▪ Cataracts (damage to the lens of the eye that can affect vision) ▪ Bone damage called aseptic necrosis. If damage is severe, the patient will need to have part of
the affected bone and the joint replaced.
▪ Leukemia that can develop because of damage to bone marrow cells Graft-versus-host disease is the major complication of allogeneic (donor) stem cell transplants. It occurs after an allogeneic transplant because the immune system of the patient is taken over by that of the donor. The donor immune system then begins reacting against the patient. The most disabling symptoms are severe rashes with itching and severe diarrhea. The liver and lungs may also be damaged. The patient may develop fatigue and muscle aching. Sometimes the graft-versus-host disease becomes chronic and disabling. If it is severe enough, it can be fatal. Usually drugs can control most of the symptoms of graft-versus-host disease. On the positive side, the graft-versus-host disease also leads to graft-versus-lymphoma activity. Lymphoma cells remaining after the chemotherapy and radiation therapy will often be killed by immune reactions of the donor cells. (For information about bone marrow and stem cell transplants, please refer to the American Cancer Society document, "Bone Marrow and Peripheral Blood Stem Cell Transplants.") Revised: 03/01/2004 Copyright 2007 American Cancer Society, Inc. All content and works posted on this website are owned and copyrighted by the American Cancer Society, Inc. All rights reserved.
Civil Action Group, Ltd. 7800 Glenroy Road Minneapolis, MN 55439 Phone: 952.831.7776 Tol Free: 1.800.328.7171 Fax: 952.831.8150 Company Profile vil Action Group, Ltd. is the largest full service legal support company in the world. Since 68, CAG has provided the highest quality service to almost every large law firm in the U.S. T his same superior level of servi
GeneDx 207 Perry Parkway Gaithersburg, MD 20877 Phone: 301-519-2100 Fax: 301-519-2892 E-mail: firstname.lastname@example.org www.genedx.com Genetic testing of the SCN9A Gene in Inherited Pain Syndromes Includes: Inherited erythromelalgia (IEM); Paroxysmal extreme pain disorder (PEPD); Small fiber neuropathy (SFN); Congenital indifference to pain (CIP) Mend