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PGF Veyx®
PGF Veyx® forte
PGF -Agonists
Therapy of oestrus disorders
and uterine diseases
Control of farrowing dates
Synchronisation of the oestrous
cycle, induction of abortion and
parturition in cattle
Reliable luteolysis
Hardly any adverse reactions
The active substance Cloprostenol contained in PGF Veyx® and PGF Veyx® forte be-longs to the group of Prostaglandin F -agonists that exhibit luteolytic effect depen- ding on the species and the time of administration. In addition to that this active substance group exhibits contractile activity on the smooth musculature (uterus, gastrointestinal tract, respiratory tract, vascular system).
The luteolytic effect of cloprostenol is 200- to 400-times higher compared to pros-taglandin F . Its effect on the smooth musculature, however, is comparable to that The administration of PGF agonists such as PGF Veyx® or PGF Veyx® forte during dioestrus or in the case of persisting corpus luteum leads to luteolysis. The resulting termination of the negative feedback mechanism caused by progesterone initiates the commencement of oestrus and ovulation in animals with cyclic ovarian func-tions. The mode and duration of administration of PGF agonists in cattle within the scope of the so-called ‘Ovsynch-procedure’ is described in detail in the product leaflet of the product Gonavet Veyx®. Through the treatment of PGF agonists abortion or birth can also be induced in the case of dead foetuses (e. g. mummified or macerated foetuses) or hydramnion/hydrallantois.
In cattle it is possible to stimulate lung maturation of the foetus and to reduce the incidence of respiratory distress syndrome in the premature calf through the applica-tion of PGF agonists where interruption of gestation is required for the dam’s sake (e. g. due to severe diseases of the dam) at least 24 hours before the planned date of birth. However, in cattle of the „German Black Pied“ breed this measure is in most cases not successful before a gestation age of at least 258 days.
The instructions for use of the products PGF Veyx® and PGF Veyx® forte are summa-rised following hereafter. Both preparations have marketing approval for the species cattle and pigs and only differ in the concentration of the active substance and consequently in the dosage rates.
Instructions for use
PGF Veyx® 0.0875 mg/ml solution for injection for cattle and pigs
Cloprostenol
PGF Veyx® forte 0.250 mg/ml solution for injection for cattle and pigsCloprostenol Active substances and other ingredients
PGF Veyx® is a clear, colourless aqueous solution for injection containing:
Active substance:
Cloprostenol
0.0875 mg/ml (corresponding to 0.092 mg/ml cloprostenol sodium) PGF Veyx® forte is a clear, colourless aqueous solution for injection containing:Active substance:Cloprostenol 0.250 mg/ml (corresponding to 0.263 mg/ml cloprostenol sodium) Indications
Cattle (heifers, cows):
- Scheduling of oestrus and ovulation and oestrus synchronisation in animals with
ovulation cycle for application during dioestrus (induction of oestrus in case of silent oestrus, synchronisation of oestrus) - Anoestrus and uterine diseases in case of progesterone-caused cycle blockade (oestrus induction in case of anoestrus, endometritis, pyometra, corpus luteum cysts, follicle lutein cysts, shortening of service period) - Induction of abortion until day 150 of pregnancy- Mummified foetuses- Induction of parturition Pigs (sows):Induction and synchronisation of parturition, respectively, beginning on day 114 of pregnancy (the last day of insemination is the first day of pregnancy).
Contraindications
- Do not use intravenously
- Do not use in pregnant animals for which the induction of abortion or parturition
- Do not use in case of spastic diseases of the respiratory system and the gastroin- Adverse reactions
If germs enter the tissue by way of the injection, the occurrence of infections caused
by anaerobes has to be reckoned with. This is particularly true for the intramuscular
injection.
Cattle: If applied for the induction of parturition in cattle, increased occurrence of
placental retention must be assumed depending on the time of treatment.
Pig: The abnormal behaviour that might occur in pigs immediately after treatment,
when the drug has been applied for induction of parturition, is similar to that of sows
before normal birth and normally subsides within one hour.
If you notice any serious effects or other effects not mentioned in this leaflet, please
inform your veterinary surgeon or pharmacist.
Target species
Cattle (heifers, cows) and pigs (sows)
Dosage for each species, routes and method of administration
For intramuscular injection in cattle (heifers, cows).
For deep intramuscular injection in pigs (sows) (needle length min. 4 cm)
Cattle (heifers, cows): 0.5 mg Cloprostenol per animal, equivalent to 5.7 ml PGF Veyx® per animal equivalent to 2.0 ml PGF Veyx® forte per animal For oestrus synchronization in a cattle herd, treatment of ani-mal groups is carried out twice at an interval of 11 days.
equivalent to 2.0 ml PGF Veyx® per animal equivalent to 0.7 ml PGF Veyx® forte per animal (use automatic syringe equipment for 50 ml perforable bottle) The rubber stopper of the vial may be safely pierced up to 25 times. Otherwise, auto-matic syringe equipment or a suitable draw-off needle should be used for the 50 ml vials to avoid excessive piercing of the closure.
Advice on correct administration
See „Dosage for each species, routes and method of administration“
Withdrawal periods
Cattle, pig:
Special storage precautions
Keep out of the reach and sight of children. Do not store above 25 °C. Keep the bottle
in the outer carton.
Do not use after the expiry date which is stated on the label and the outer carton.
Shelf life after first opening the container: 28 days. After the expiry of this period the
remainer of the drug in the container is to be disposed of.
Special warnings
Injections into soiled cutaneous areas should be avoided for the reason of infections
caused by anaerobes. Before application the injection site should be cleaned and
disinfected thoroughly.
Pig: Only use the medicinal product if the mating dates are known. If administered
at a too early stage, the viability of the piglets can be impaired. This is the case if the
injection is administered more than 2 days before expiry of the mean pregnancy pe-
riod of the stock. The last day of insemination is reckoned as the 1st day of pregnancy.
The duration of pregnancy generally ranges between 111 and 119 days.
Special precautions to be taken by the person administering the veterinary medicinal product to animals: - This product must be handled carefully to avoid accidental self-injection or con- tact with the skin or mucous membranes of the user.
- Prostaglandins of the F type may be absorbed through the skin and may cause - Pregnant women, women in childbearing age, asthmatics and people suffering from other respiratory tract diseases should wear waterproof gloves during admin- istration of the product. - Accidental spillage on the skin should be washed off immediately with soap and - In case of accidental self-injection, seek medical advice and show the package leaflet to the doctor. Should respiratory distress result from accidental inhalation or injection, a rapid acting bronchodilator, e.g. isoprenaline or salbutamol by in-halation is indicated.
Use during pregnancy, lactation or lay: Do not use in animals where induction of abortion or parturition is not desired. The safety of the veterinary medicinal product during lactation has not been established.
Interaction with other medicinal products and other forms of interaction: Oxytocin and Cloprostenol applied simultaneously increase the efficacy on the uterus.
Overdose (symptoms, emergency procedures, antidotes), if necessary: In case of overdosing the following symptoms may occur: Intensification of pulse and respiratory rate, bronchoconstriction, increase of the body temperature, increa-sed defecation and urination, salivation, nausea and vomiting.
No antidotes available.
Incompatibilities:In the absence of compatibility studies, this veterinary medicinal product must not be mixed with other veterinary medicinal products.
Special precautions for the disposal of unused product or waste
materials, if any
Any unused veterinary medicinal product or waste materials derived from such ve-
terinary medicinal product should be disposed of in accordance with local require-
ments. Ask your veterinary surgeon how to dispose of medicines no longer required.
Package sizes
PGF Veyx
Veyx-Pharma is GMP-, QS- and DIN EN ISO 9001-certified.
Veyx-Pharma GmbH · Soehreweg 6 · 34639 Schwarzenborn · Germany Phone 0049 5686 99860 · Fax 0049 5686 1489 · E-Mail zentrale@veyx.de

Source: http://www.veyx.net/fileadmin/_veyx/pdfs/KB_PGF_Veyx_PGF_Veyx_forte_EN.pdf

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