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Vicky khanna

Vicky Khanna
C-1 Shiv Vihar, Dwarka Modh, New Delhi, India ¬ To Create, Invent or Discover something that compliments Humankind.
¬ Pursuing Masters in Technology (Bio-Informatics)
International Institute of Information Technology, Hyderabad, A.P. India.
¬ Bachelors in Technology (Biotechnology)
Ambala College of Engineering and Applied Research, Ambala (ACE&AR)Kurukshetra University, Kurukshetra, Haryana, India.
Scaled marks
University
Ambala College of Engg. & Applied Research, ¬ Molecular Pathway Modelling & Analysis ¬ Published Paper Titled “Anti-Alzheimer’s Drug-VikAsthra” in Annual journal of IIT-
Kanpur - Eureka.
Abstract:
Alzheimer's disease (AD) is a neurodegenerative disease with symptoms like short-term memory loss and visual-spatial confusion. On the basis of "cholinergic hypothesis" various drugs have been designed which inhibits acetyl cholinesterase (AchE), an enzyme that breaks down the neurotransmitter acetylcholine at the synaptic cleft. AChE-inhibitors like Huperzine B and Donepezil reduce the rate at which acetylcholine (ACh) is broken down thereby contributing to the clinical efficacy in AD treatment.
Structure based drug design approach was used to design new and more effective analogues of existing ACh inhibitors. Using scaffolds from Donepezil and Huperzine, three different combinatorial libraries were enumerated. Libraries were filtered using Lipinski’s rule of five and docked with the receptor after active site identification and validation. By intensive analysis and interaction site calculation, three potent hits were obtained which have up to 150% decrease in docking energy as compared to Donepezil and Huperzine. These were named as1) VikAstra I- Similar to Donepezil.
2) VikAstra II - Donepezil and Huperzine B Chimera.
3) VikAstra III - Novel Structure.
¬ Development of Web Tool and Database for identifying peptide periodic repeats (PEPPER).
The project is to maintain an already existing web application of Peptide Periodic repeat finder. The need was to: - 1. Change the already existing web interface,2. Increase the efficiency of the system and3. Development of Database for Repeats in Protei The project demands of learning how to fetch a file from the client, then process it on server and display on the results to the user. The database creation used PERL scripting to parse fasta and protein files for finding the repeats (which are then inserted into database) and cross-referencing the repeats (so found) to other databases.
My solo efforts to produce web application and database creation has helped me to learn PHP, MySQL, PERL, HTML, C languages with many basics of web application development.
¬ Dynamic Modelling of Vascular Smooth Muscle Cells: The project involves modeling of various membrane pumps that determines the membrane potential, salts (i.e Ca, Na, K conc) inside the cells with respect to time. It demands coding in C with application of gsl libraries for solving differential equations. While modeling I have developed basics of integrators and complex equations which involved concepts of file handling, pointers, memory management etc.
¬ Analysis & Modeling of NSAID Drug Pathways.
This project is my independent study endeavor to learn and analyze a pathway from a systemic point of view. The project has helped me a lot in generating my intuitions for the nature of response of different types of metabolic/drug pathways. For the analysis of NSAIDS we have to first model the cox and pox pathways. This was a challenging task as there were many values of rate constants predicted and some rate constants were even not reported in the literature. So the most challenging task was to model the pathway which consists of total 8 cycles (5 POX and 3 COX). The model was built on COPASI software which included some 140 odd reactions and some 50 differential equations. The model was then validated with the previous literature work reported. Asprin action on COX had already been analysed which is in accordance to the previous work reported. The project is in its final stages where the action of celecoxib (another NSAID) will be analyzed and then finally VIOXX will be tried. It will also be used for analysis of different combination of drugs and its effects.
¬ In-silico Drug Designing and analysis of Anti-Alzheimer’s Drug using Advanced
Structure based drug design approach was used to design new and more effective analogues of existing ACh inhibitors. Using scaffolds from Donepezil and Huperzine, three different combinatorial libraries were enumerated. Libraries were filtered using Lipinski’s rule of five and docked with the receptor after active site identification and validation. By intensive analysis and interaction site calculation, three potent hits were obtained which have up to 150% decrease in docking energy as compared to Donepezil and Huperzine. ¬ Isolation, Cloning and characterization of DNA polymerase from Thermus Thermophilus.
¬ Identifying Unique Conserved Region Among Conserved Region of Genomes in
Evolution Right from The Very Primitive Species to Highly Advanced Species, using
Bioinformatics tools.
¬ GATE Scholarship for the year 2009-2011 to pursue M-Tech in IIIT-Hyderabad
SYSTEMS BIOLOGY MODELNIG EXPERIENCE:-I have successfully modeled:- • (Dynamic Calcium concentrations in Cells. (ref:-“Ca Dynamics in a population of Smooth Muscle Cells: Modeling the Recruitment and Synchronization.” BioPhy Jounl vol 87 July (2004) 92-104.) NSAID Pathway (i.e. COX and POX pathways ref:- Alexey Goltsov et al. Kinetic modelling of NSAID action on COX-1: Focus on invitro/in vivo aspects and drug combinations European journal of pharmaceutical sciences 36 (2009) 12-16) Epidermal Growth factor Pathway. (ref:- Boris N. Kholodenko et al. "Quantification of Short Term Signaling by the Epidermal Growth Factor Receptor", Journ of Biol Chem. Vol. 274, No. 42,October 15,1999 30169 –30181) G-Protein Cycle of Yeast. (ref:- Yi et al. “A quantitative characterization of the yeast heterotrimeric G protein cycle” PNAS.September16,2003 vol. 100((10764 –10769)) ¬ Worked as a Software Engineer with Infosys Technologies Limited from 2nd March 2009 to 30th
Aug 2009.
¬ Basics of Computer:
¬ Advanced: C, C++, C#, ORACLE, MySQL,Dot Net-Asp.Net, ADO.net,
Visual Basic, PHP, PERL, Python, HTML.
ACHIEVEMENTS:
AT GRADUATE LEVEL:
¬ Recipient of Dean’s Award for Academic Excellence during year 2009-2010.
¬ Recipient of Gate Scholarship for the M-Tech program in IIIT for 2009-2011.
AT UNDERGRADUATE LEVEL:
¬ Recipient of Second Prize in Poster Presentation at International conference
Techkriti’08 organized by IIT-Kanpur.
¬ Awarded First Prize in Paper presentation at National level Technical Festival, 2008.
¬ Awarded Second Prize in Paper presentation at National level Technical Festival, 2008.
¬ Awarded Second Prize in Paper Presentation at National level Technical Festival 2007.
¬ Recipient of Second Prize in Paper Presentation at National level Technical Symposium
¬ Recipient of Third Prize in Paper Presentation at college.
¬ Distinctive Recognition of model at Science Fair-07 organized by Renewable Energy
Club-ACE & AR sponsored by HAREDA.
¬ Organized and Participated in Patent Awareness Workshop-ACE&AR sponsored by
TIFAC and HSCST (DST) Gov. of India.
AT SCHOOL LEVEL:
¬ Represented school in Various Debates Declamations and Mono acting at district level.
¬ Won Second prize in volley ball at zonal level.
¬ Awarded Best Parliamentarian at youth parliament by Kapil Dev.
¬ Recipient of many prizes in various Debates, Declamations, Extemporary, Recitation
and Speeches.
¬ Recipient of First Prize in exam conducted by Delhi State Science Forum.
Date: 10th Mar, 2011 (Vicky Khanna)

Source: http://web.iiit.ac.in/~vicky.khanna/downloads/vicky_resume.pdf

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