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Bedford laboratories

MATERIAL SAFETY DATA SHEET
Section I - IDENTITY
Common/Trade Name: Doxycycline for Injection, USP
Chemical Names: 2-Napthacenecarboxamide,4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-
3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo- Synonyms: Vibramycin Intravenous, Doxycycline, Liviatin, Doxiciclina, GS-3056
Manufacturer's Name:
Address:
Emergency Telephone Number:
Telephone Number for Info.: (440)232-3320 -or- (800)562-4797
Medical Emergency: Professional Services 1(800)521-5169
Date Prepared:
Section II - HAZARDOUS INGREDIENTS/COMPOSITION INFORMATION
Other Limits
Component
OSHA PEL ACGIH TLV
Recommended
Doxycycline is a sterile lyophilized drug provided in a vial.
Section III - HEALTH HAZARD DATA
Routes of Entry: Under normal use, Doxycycline presents little hazard. It may be
absorbed through the skin, through ingestion or via inhalation of aerosols.
Health Hazard (Acute & Chronic): Doxycycline is a broad spectrum antibiotic used to treat a variety of
gram positive and gram negative organisms. It may affect the digestive system and may cause allergic reactions. Carcinogenicity:
NTP? NO IARC Monographs?
OSHA Regulated? NO
Signs & Symptoms of Exposure: Doxycycline may cause irritation to the eyes, skin and respiratory
tract. It may also cause nausea, vomiting diarrhea, and difficulty in swallowing. May cause allergic
Medical Conditions Generally Aggravated by Exposure: Persons who are allergic to tetracyclines.
BVL Hazard Category: 2
Section IV - FIRST AID MEASURES
Eye Exposure: Flush eyes with large volumes of water for 15 or more minutes.
Skin Exposure: Wash skin with cool, soapy water for 15 minutes.
Ingestion:
If ingestion occurs, flush mouth with water and seek medical attention immediately.
If person is conscious, induce vomiting. Never induce vomiting on an unconscious person.
Inhalation:
If difficulty breathing, administer oxygen. Seek attention of a physician immediately.
If necessary, provide artificial respiration.
Section V - FIRE AND EXPLOSION HAZARD DATA
Flash Point (Method Used): Not Applicable LEL: Not Applicable UEL: Not Applicable
Flammable Limits: Not Applicable
Extinguishing Media: Use water or an ABC multi-purpose extinguisher.
Special Fire Fighting Procedures: As with all fires, evacuate personnel to a safe area. Fire fighters
should wear self-contained breathing apparatus to avoid inhalation of smoke. Unusual Fire/Explosion Hazards: NONE
Section VI - ACCIDENTAL RELEASE INFORMATION
Release to Land: Wet and wipe up Doxycycline with absorbent materials and dispose according to local,
Release to Air: If aerosolized, reduce exposures by ventilating area; clean up spill immediately to
Release to Water: Refer to local water authority. Drain disposal is not recommended; however,
refer to local, state, and federal disposal guidelines.
Section VII - PRECAUTIONS FOR SAFE HANDLING AND USE
Steps to be taken in case material is released or spilled: See Section VI above.
Wear latex or nitrile gloves and safety glasses when cleaning spills. A dust/mist respirator (N95)may be necessary if excessive aerosols are generated.
Waste Disposal Method: Incineration in an approved incinerator is recommended. Refer to local, state,
Precautions to be taken in handling and storing: Store at 25º C (77ºF). Follow instructions
provided in packaging. Protect from light.
Other Precautions: NONE
Section VIII - CONTROL MEASURES AND PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Under normal use, respirators are not required. If aerosols are generated, a
disposable dust/mist respirator (N95) may be used. Personnel wearing respirators should be fittested and approved for respirator use under the OSHA Respiratory Protection Standard 29 CFR1910.134.
Ventilation: Handle product in a well-ventilated area.
Protective Gloves: Latex or nitrile
Eye Protection:
Other Protective Clothing or Equipment: Lab Coat
Work/Hygienic Practices: Wash hands following use. No eating, drinking, or smoking while
Section IX - PHYSICAL/CHEMICAL CHARACTERISTICS
Physical State: Solid
Specific Gravity: Not Applicable
Appearance and Odor: White, odorless
Melting Point: Unknown
Boiling Point: Not Applicable
Evaporation Rate: Not Applicable
Vapor Pressure: Not Applicable
Solubility in Water: Soluble
Vapor Density: Not Applicable
pH: 6.0-7.5
Section X - STABILITY AND REACTIVITY DATA
Stability: Stable
Incompatibility (Materials to Avoid): Strong oxidizers or water-reactive materials.
Hazardous Decomposition or Byproducts: Decomposition products of this compound may include
potentially hazardous byproducts of nitrogen oxides, carbon monoxide, carbon dioxide, andsulfur oxides.
Hazardous Polymerization: Will not occur
Conditions to Avoid: Storage near oxidizers and water reactive materials
Section XI - TOXICOLOGICAL INFORMATION
LD50 mouse, intravenous = 241 mg/kgLD50 mouse, oral = 1870 mg/kgLD50 rat, intraperitoneal = 378 mg/kgLD50 rat, intravenous = 228 mg/kgLD50 rat, oral = >2 g/kgLD50 mouse, intraperitoneal = 410 mg/kg LD50 dog, intravenous = >100 mg/kgLD50 dog, oral = >500 mg/kg Additional reproductive health data is available from the National Institute for Occupational Safety andHealth (NIOSH) Registry of Toxic Effects of Chemical Substances (RTECS).
Section XII - ENVIRONMENTAL IMPACT INFORMATION
Information is currently not available on the environmental impact of Doxycycline. Handle in a manner toprevent spills or releases to the environment.
Section XIII - DISPOSAL INFORMATION
Dispose of by incineration at an approved/permitted incinerator.
Review local, state, and federal regulations for your regulatory area.
Section XIV - TRANSPORTATION INFORMATION
Doxycycline is not a DOT hazardous material.
Doxycycline is not a DOT Marine Pollutant.
Section XV - REGULATORY INFORMATION
Doxycycline is listed on California’s Proposition 65 List as Code D Section XVI - OTHER DATA
Use of this product should be through or under the direction of a physician.
This MSDS does not address therapeutic use of this material.
Persons administering this drug to patients must be careful to avoid needle sticks to syringes and other sharps used in the administration. All needle sticks must be reported to your companymanagement.
The information provided is believed to be complete and accurate. It is the user's responsibility to use the information according to theirapplication. Bedford Laboratories and Ben Venue Labs, Inc. assumes no additional liability or responsibility resulting from the use of orreliance on this information.

Source: http://amatheon.com/msds/Doxycycline_Inj_Bedford.pdf

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