Fisher BioReagents® Antibiotics and Antimycotics
In many life science laboratories, the in vitro culturing of bacterial,
Optimized for cell culture
plant, and animal cells is a routine task. High quality antibiotics and antimycotics from Fisher BioReagents can be used to ensure success-ful growth of cells by eliminating unwanted bacterial strains and fungi while maintaining the health and vitality of the desired cells. Advantages t High quality - antibiotics and antimycotics meet rigorous quality
control tests, including verifi cation of potency, purity, and solubility using microbiological and chromatographic methods.
t Built for selection - excellent choice of antibiotics for selection of
antibiotic resistance genes in both bacterial and mammalian cells.
t High purity and stability - ultrapure antibiotics ensure successful
growth of target cells and reproducible results.
t Maximum convenience - antibiotics and antimycotics come in both Applications
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Table 1. Antibiotic modes of action Molecular Catalog No. Product Description Mode of Action Susceptible Organisms Packaging
Inhibitor of protein disulfide isomerase. Interferes with
BP2950-1
building blocks of peptidoglycan bacterial cell wall. Inhibitor of bacterial cell wall synthesis. Eliminates
BP2951-1
Agrobacterium species after inoculation.
Alters membrane permeability and allows potassium ion
BP2949-5 BP2953-1
Interferes with peptidoglycan synthesis in bacterial cell
BP2955-5
Interferes with synthesis of bacterial cell wall. Inhibits
BP2959-50*
protein synthesis; binds to 30S ribosomal subunit.
Interferes with synthesis of bacterial cell wall. Inhibits
BP2960-50*
protein synthesis. Interferes with bacterial cell division.
Interferes with synthesis of bacterial cell wall. Inhibits
BP2961-50*
protein synthesis. Disrupts the integrity of DNA, and blocks S-phase entry
BP2962-100 BP2954-1
Interferes with cytoplasmic membrane. BP2956-100
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BP2963-1
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BP2957-1
Inhibits formation of peptidoglycan polymers of bacterial
BP2958-1 * Molecular weights are not available because products are mixtures.Table 2. Selective antibiotics used in transformation studies Catalog No. Product Description Antibiotic Resistance Genes
The aph4 gene (also known as hph or hyg) encodes an enzyme, hygromycin phosphotrans-
BP2952-1MU
ferase, which confers resistance to hygromycin B. This antibiotic is particularly useful as a
selective agent for the incorporation of aph4 in plant tissue.
Phleomycin resistance is conferred by the Sh ble gene from Streptoalloteichus hindustanusBP2962-100
which encodes a protein that binds to phleomycin, inhibiting its DNA cleavage activity. Useful
in transformation studies involving plant and mammalian cells.
Selection agent for cells transformed with pac gene. Used for stable transfection of DNA into
BP2956-100
Resistance to spectinomycin may develop by mutations in rpsL gene that prevent this
BP2957-1
antibiotic from binding to the 30S ribosomal subunit and inhibiting proper translation;
streptomycin resistance is recessive. Table 3. Additional antibiotics available from Fisher BioReagents Catalog No. Product Description BP928, BP2645 Hygromycin B
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Your GP or Endocrinologist may also check: What do I need to know about my medication? Hypoparathyroidism The aim of treatment is to abolish symptoms – not to restore ‘normal’ calcium levels in the blood. In the absence of PTH, higher levels of calcium are found in the urine for a given blood calcium level. When hypoparathyroidism occurs as a complication This can caus
CONCILIACIÓN y ARBITRAJE Medidas precautorias en un proceso arbitral La Ley 1770 de Arbitraje y Conciliación en sus artículos 35, 36 y 37 establece la posibilidad de aplicar Medidas Precautorias. El sometimiento de la resolución de una causa a través de un Arbitraje, muchas veces crea laincertidumbre de si la parte demandada cumplirá con lo dictado en el Laudo Arbitral. Para ello,
Fisher BioReagents® Antibiotics
Table 2. Selective antibiotics used in transformation studies