COMPOSITION 100 gram IMEX contains 3.0 g Tetracycline as an active ingredient. As excipients, White vaseline, medium chain triglyceride, Titanium dioxide, Brown iron oxide, Red iron oxide exist. PHARMACOLOGICAL PROPERTIES According to common belief about acne pathogenesis among physician, acne formation is associated with clogging of pilosebaceous gland follicles. This occurs as a result of defective keratinization of follicles. It has been proven that Tetracycline is effective against to all factors involving in acne development: – Reduction of lipase in Propionibacterium acnes – Inhibition of chemotaxis of polymorph nuclear lymphocytes – Blockage of free oxygen radicals’ release from polymorph nuclear lymphocytes – Antagonism of calmodulin activity
Following topical application tetracycline should be available between 0.05 microgram/ml – 100 microgram/ml in the affected area,. It was demonstrated that tetracycline’s follicular concentration was equal to 64 microgram/ml or greater, after topical Imex administration. Severe acne forms are characterized with persistent inflammatory nodules, which end up with scars that cause dysmorphosis. Histological examinations of these lesions indicated that intense lymphocytic and granuloma formation. It was believed that granuloma stimulation arises from Propionibacterium acnes. Tetracycline’s well known effect probably may be related partially to its antigranuloma activity. It was shown that in vitro inhibition of granuloma formation is due to Protein Kinase C inhibition. Antibiotics (ampicillin, cefalotin, erythromycin and clindamycin) that have no effects on granuloma either have no effects or little effects on Protein Kinase C. It has been determined that Imex’s active ingredient tetracycline does not penetrate into corium even in the highest concentration. Since Imex does not contain penetration mediator, it is not possible to be absorbed and to have systemic effect. INDICATIONS Topical acne treatment, particularly inflammatory forms. CONTRAINDICATION Imex should not be used in individuals who have a known hypersentivity to tetracycline.
WARNINGS / PRECAUTIONS Imex should not be used after expiry date. According to current knowledge, it is recommended that patients should take following precautions in addition to medical treatment: • Skin should be cleaned regularly but not vigorously with non-alkaline soap preferably.
• In spite of comedones can be cleaned; do not mechanically remove acne with signs of
inflammation and pustules, in order to avoid scar formation.
• Do not apply make-up or use face powder, in order to avoid re-clog of sebaceous glands. USE IN PREGNANACY AND LACTATION Although there is no information about teratogenic effect and sign of Imex’s usage, no clinical studies have been conducted with Imex in pregnant and nursing women. Therefore, as with all other products, it is not recommended to use in pregnant women. UNDESIRABLE EFFECTS By this time, no significant side effects have been reported with the use of Imex. It is well tolerated by patients. IN CASE UNDESIRABLE EFFECTS, PLEASE CONSULT YOUR DOCTOR. DRUG INTERACTIONS No drug incompatibilities have been reported with topical use of Imex. METHOD OF ADMINISTRATION Unless, prescribed otherwise by physician, apply daily 1- 3 times to the affected skin area, gently massage to allow its penetration. OVERDOSE There is no knowledge about overdose of Imex Ointment. STORAGE CONDITIONS Keep it at room temperature under 25 °C. Keep out of the reach and sight of the children and store it in its package. COMMERCIAL PRESENTATION AND CONTENT OF CONTAINER IMEX ointment presented in 20 gram aluminum tubes. REGISTRATION OWNER AND IMPORTER ASSOS İlaç, Kimya, Gıda Ürünleri Üretim, Tic. Ltd. Şti, ÜMRANİYE 34773, İSTANBUL MANUFACTURER Merz Pharmaceuticals, GmbH, Frankfurt, Germany REGISTRATION NUMBER: 26.11.2001, 111/25 AVAILABLE WTH PRESCRIPTION
RESULTS OF DANCE SECTIONS – WYNNUM MANLY EISTEDDFOD 2011 WEDNESDAY 26-4-2011 JEMMA POAK, ALICIA STIBBARD, ELLEN GWILLIM VHC ALICIA STIBBARD, VHC KAYLEE SCHIPPLOCK HC AMELIA BOFINGER, KAYLA BECHLY, IRELAND KNOWLES, NIA SAVAS, JACK JONES,ELLIE CASEY HC MIDORI KAYE, BROOKE STANEK, ELLIE CASEY D204 SONG AND TAP GROUP 6 YRS & UNDER D176 MODERN JAZZ U/T GROUP 6YRS & UNDER D198 SONG
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