Le métronidazole (Flagyl) reste la référence dans le traitement des infections anaérobies et des parasitoses comme la giardiase ou l’amibiase. Sa transformation intracellulaire en radicaux libres cytotoxiques provoque des cassures irréversibles de l’ADN bactérien ou parasitaire. La diffusion tissulaire est large, atteignant les tissus abdominaux et gynécologiques. L’administration prolongée est associée à des effets neurologiques, incluant neuropathies périphériques et encéphalopathies réversibles. L’association avec l’alcool déclenche une réaction de type antabuse. Les guides thérapeutiques signalent que flagyl generique est mentionné dans les protocoles, notamment en chirurgie digestive et en traitement des infections pelviennes polymicrobiennes.
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Common Name : DIMENSION CRBM FLEX REAGENT CARTRIDGE Manufacturer : DADE BEHRING Internal ID : QADM0125 Revision Date : 01-10-2004 File Name : 001735 Material Safety Data Sheet ---------------------------------------------------------------------- "DIMENSION" CLINICAL CHEMISTRY SYSTEM CRBM FLEX(R) REAGENT CARTRIDGE QADM0125 Revised: 01/10/2004 ---------------------------------------------------------------------- CHEMICAL PRODUCT/COMPANY IDENTIFICATION Tradenames and Synonyms CAT. NO. DF87 CARBAMAZEPINE FLEX(R) REAGENT CARTRIDGE CRBM FLEX(R) REAGENT CARTRIDGE "DIMENSION" CRBM FLEX(R) REAGENT CARTRIDGE AMAPS 717087.901 Company Identification MANUFACTURER/DISTRIBUTOR Dade Behring Inc. P. O. Box 6101 Newark, DE 19714-6101 PHONE NUMBERS Product Information : 800-441-9250 Transport Emergency : CHEMTREC 800-424-9300 Medical Emergency : 800-228-5635 ext 284 COMPOSITION/INFORMATION ON INGREDIENTS Components Material CAS Number % Carbamazepine Antibody Reagent Sodium Chloride 7647-14-5 6 ProClin 300 0.2 Neomycin Sulfate 1405-10-3 0.01 Water 7732-18-5 >92 Carbamazepine Particle Reagent GAFAC, neutralized 6 ProClin 300 0.2 Neomycin Sulfate 1405-10-3 0.01 Water 7732-18-5 >92 Common Name : DIMENSION CRBM FLEX REAGENT CARTRIDGE Manufacturer : DADE BEHRING Internal ID : QADM0125 Revision Date : 01-10-2004 File Name : 001735 Carbamazepine Assay Buffer GAFAC 51811-79-1 0.6 ProClin 300 0.2 Neomycin Sulfate 1405-10-3 0.01 Water 7732-18-5 >96 HAZARDS IDENTIFICATION Potential Health Effects Since this mixture has not been tested as a whole to determine the hazards by all routes of exposure, information is provided for each hazardous component of the mixture to meet requirements of OSHA's Hazard Communication Standard (29 CFR 1910.1200). The effects noted occur from exposure to the pure component unless otherwise noted. INFORMATION FOR COMPONENTS SODIUM CHLORIDE is an IRRITANT. Human health effects of overexposure by inhalation, ingestion, or skin or eye contact may cause nonspecific discomfort, such as nausea, headache, or weakness upon ingestion; or eye irritation with tearing, or blurring of vision on eye contact. GAFAC is CORROSIVE to skin and eyes. Skin contact may cause irritation with discomfort, rash, burning sensations, inflammation, skin burns, painful blisters or ulceration. Eye contact may cause painful stinging or burning of eyes and lids, watering of eyes, conjunctivitis, opaqueness of cornea, possibly leading to loss of sight. Inhalation of mist could cause irritation to mucous membranes in nose and throat with coughing and difficulty breathing. NEOMYCIN SULFATE is harmful if swallowed, inhaled, or absorbed through the skin. May case allergic skin reaction. PROCLIN 300 is a skin sensitizer. May cause allergic skin rashes. Carcinogenicity Information None of the components present in this material at concentrations equal to or greater than 0.1% are listed by IARC, NTP, OSHA or ACGIH as a carcinogen. FIRST AID MEASURES Common Name : DIMENSION CRBM FLEX REAGENT CARTRIDGE Manufacturer : DADE BEHRING Internal ID : QADM0125 Revision Date : 01-10-2004 File Name : 001735 First Aid INHALATION Inhalation is not an expected route of exposure during normal use of the product. SKIN CONTACT Flush skin with water after contact. Wash contaminated clothing before reuse. EYE CONTACT In case of contact, immediately flush eyes with plenty of water for at least 15 minutes. Call a physician. INGESTION Ingestion is not an expected route of exposure during normal use of the product. If ingested, consult a physician. FIRE FIGHTING MEASURES Flammable Properties Material is a nonflammable water-based solution. Extinguishing Media Use media appropriate for surrounding material. Fire Fighting Instructions Evacuate personnel to a safe area. Wear full protective equipment. ACCIDENTAL RELEASE MEASURES Safeguards (Personnel) NOTE: Review FIRE FIGHTING MEASURES and HANDLING (PERSONNEL) sections before proceeding with clean-up. Use appropriate PERSONAL PROTECTIVE EQUIPMENT during clean-up. Initial Containment Common Name : DIMENSION CRBM FLEX REAGENT CARTRIDGE Manufacturer : DADE BEHRING Internal ID : QADM0125 Revision Date : 01-10-2004 File Name : 001735 Dike spill. Spill Clean Up Soak up with sawdust, sand, oil dry or other absorbent material. Comply with Federal, State, and local regulations for reporting releases. HANDLING AND STORAGE Handling (Personnel) Avoid contact with eyes, skin or clothing. Do not store or consume food, drink or tobacco in areas where they may become contaminated with this material. Wash hands and contaminated skin thoroughly after handling. See product/insert sheet. EXPOSURE CONTROLS/PERSONAL PROTECTION Personal Protective Equipment Eye/Face : safety glasses Protective Gloves : latex or nitrile Exposure Guidelines Exposure Limits: None Established PHYSICAL AND CHEMICAL PROPERTIES Physical Data Self-contained cartridge with Particle Reagent in wells 1 and 2, Assay Buffer in wells 3 and 4, Antibody Reagent in wells 5 and 6. STABILITY AND REACTIVITY Chemical Stability Stable at normal temperatures and storage conditions. Common Name : DIMENSION CRBM FLEX REAGENT CARTRIDGE Manufacturer : DADE BEHRING Internal ID : QADM0125 Revision Date : 01-10-2004 File Name : 001735 Decomposition Decomposition does not occur under normal use conditions. Polymerization Polymerization will not occur. DISPOSAL CONSIDERATIONS Waste Disposal Treatment, storage, transportation, and disposal must be in accordance with applicable Federal, State/Provincial, and Local regulations. REGULATORY INFORMATION State Regulations (U.S.) WARNING - SUBSTANCES KNOWN TO THE STATE OF CALIFORNIA TO CAUSE CANCER, BIRTH DEFECTS OR OTHER REPRODUCTIVE HARM- Neomycin Sulfate OTHER INFORMATION "DIMENSION" is a trademark of Dade Behring Inc. ---------------------------------------------------------------------- The data in this Material Safety Data Sheet relates only to the specific material designated herein and does not relate to use in combination with any other material or in any process. Technical Assistance Center Dade Behring Inc. Newark, DE 19714-6101 1-800-441-9250 End of MSDS
Dioxygen Activation under Ambient Conditions: Cu-Catalyzed Oxidative Amidation - Diketonization of Terminal Alkynes Leading to r -Ketoamides State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking Uni V ersity, Xue Yuan Road 38, Beijing 100191, China, and State Key Laboratory of Organometallic Chemistry, Chinese Academy of Received October 1
Lab Activity for Chapter 9 This laboratory period will be spent working on a few problems in context exercises from Chapter 9. Work on each problem as if you were doing it for homework. Use the computer to obtain graphs andnumerical data values, and to find solutions to equations using graphical and numerical methods. Then, either copy the computer results onto your homework paper by hand, or m