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Teratology course learning objectives.xls

Behavioral Objectives
Lecture #
Lecture Title
1. List the principles of teratology2. List and describe the four manifestations of abnormal 3. Define the critical periods of development4. Discuss the mechanisms of developmental toxicity 1. Describe the absorption of chemicals across different surfaces2. Discuss the volume of distribution and parameters of tissue 3. Distinguish between Phase I and Phase II metabolism4. Discuss excretion and the kinetics of elimination 1. Review key concepts in pharmacogenetics2. Discuss the history of pharmacogenetics 3. Discuss various case examples of polymorphisms in therapy4. Describe and understand caveats in pharmacogenetics 1. Discuss the formation and timing of neural tube development 2. Describe the major findings from folic acid recurrence studies 3. Explain the metabolic functions of folic acid and folic acid 1. Discuss maternal metabolic and genetic disorders 2. Describe the role of physical agents in teratogenesis3. Describe well studied viral teratogens 1. Discuss the thalidomide as a drug used in pregnancy2. Describe the nature of the limb defects seen with thalidomide embryopathy 3. Contrast the species sensitivity of thalidomide4. Discuss the various regulatory aspects and current status of thalidomide 1. Describe the major and minor malformations seen with 2. Discuss the teratogenic effects of specific antiepileptics 1. Describe the epidemiology of diabetes in pregnancy2. Describe the pathophysiology of diabetes during pregnancy3. Describe the fetal/neonatal concerns of diabetic embryopathy by system4. Discuss the management and long term risks of pregnancies complicated with diabetes 1. Describe the neurodevelopmental processes subject to toxic insult 2. Discuss the teratogenic effects of various developmental neurotoxicants 1. Describe classifications of medications 2. Discuss the teratogenic effects of various prescription medications and drugs used to treat illness Lithium in Pregnancy 2. Christine VanLengen Moskalik 1. Describe criteria of a diagnosis of FAS2. Describe the management of FAS in school aged children, adolescents, and adults3. Explain the likely mechanism of FAS4. Discuss screening and prevention of FAS 1. Review radiation2. Discuss sources of natural and man-made background radiation 3. Describe the congenital effects of ionizing radiation4. Describe the hereditary effects of ionizing radiation 1. Discuss organogenesis with respect to the central nervous system2. Describe Fetal Minimata Disease and the regulatory response that followed3. Discuss the EPA’s Developmental Neurotoxicity Test guidelines and design 1. Review retinoids and vitamin A2. Describe the normal functions of retinoids and vitamin A 3. Describe the clinical applications of retinoids4. Describe the teratogenic effects of retinoids5. Discuss current protocols aimed at preventing retinoid 1. Describe the physiologic effects of various drugs of abuse 2. Describe the teratogenicity of various drugs of abuse 1. Review common congenital infectious diseases2. Describe the patterns of fetal injury associated with congenital infections3. Review strategies relevant to prevention, treatment, and counseling 1. Contrast the actions of estrogens, progestins, and androgens2. Describe the control of sexual differentiation by steroid hormones3. Explain how endocrine disruptor chemicals can alter development 4. Give examples of the teratogenic effects of abnormal environmental exposure to reproductive endocrine disruptors



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