Le métronidazole (Flagyl) reste la référence dans le traitement des infections anaérobies et des parasitoses comme la giardiase ou l’amibiase. Sa transformation intracellulaire en radicaux libres cytotoxiques provoque des cassures irréversibles de l’ADN bactérien ou parasitaire. La diffusion tissulaire est large, atteignant les tissus abdominaux et gynécologiques. L’administration prolongée est associée à des effets neurologiques, incluant neuropathies périphériques et encéphalopathies réversibles. L’association avec l’alcool déclenche une réaction de type antabuse. Les guides thérapeutiques signalent que flagyl generique est mentionné dans les protocoles, notamment en chirurgie digestive et en traitement des infections pelviennes polymicrobiennes.
Microsoft word - chemo%20orders[1]
Mohamed S. Ahmed, MD,PhD,PC 3117 Military Road Suite #2 MOHAMED S AHMED, MD, PHD, PC Niagara Falls, NY 14304 Phone: 716-298-4869 HEMATOLOGY-ONCOLOGY Fax: 888-847-3060 CHEMOTHERAPY ORDERS Patient Name: __________________________________________ Diagnosis: _________________________________ Protocol: _______________________________________________ Course # _____________ Cycle # _______________ Height: ________inches Dosing Weight: ________lbs/kg [ ] Actual [ ] Ideal [ ] Adjusted BSA* ________m2
Ideal weight in kg = (inches >5’ x 2.3) + 45.5 (females) or 50 (males)
Adjusted weight in kg = (total weight – ideal weight) x 0.25 + ideal weight
BSA is calculated in Meditech using the Haycock equation
Parameters: ANC > 1500, PLTS > 100,000, Creatnine < 1.5 Pre-Chemotherapy Orders [ ] Zofran 16mg IV and Dexamethasone 20mg IV [ ] PACLITAXOL PREMEDS: Dexamethasone 20mg IV, Zantac 50mg [ ] Benadryl 25mg IV [ ] Solucortef 100mg IV IV, Zofran 16mg IV, Benadryl 25mg IV Chemotherapy Orders: Pharmacist may round dose by ≤5% to nearest vial size in order to minimize waste. Calculated Diluent/Volume/ Frequency weight/BSA Modification Duration (if IVPB) [ ] IV Push [ ] One Time _______mg/kg Diluent: ___________ [ ] Daily x _____________________________ ________mg Volume:___________ [ ] ___________________________________ _______mg/m2 [ ] ______% [ ] ________ Duration:__________ ______________________________________ [ ] IV Push [ ] One Time _______mg/kg Diluent: ___________ [ ] Daily x _____________________________ ________mg Volume:___________ [ ] ___________________________________ _______mg/m2 [ ] ______% [ ] ________ Duration:__________ ______________________________________ [ ] IV Push [ ] One Time _______mg/kg Diluent: ___________ [ ] Daily x _____________________________ ________mg Volume:___________ [ ] ___________________________________ _______mg/m2 [ ] ______% [ ] ________ Duration:__________ ______________________________________ Carboplatin Only: Target AUC _____ GFR _____ ml/min Dose = Target AUC x (GFR + 25) = _________mg ALLERGIES: _________________________________________ Post-Chemotherapy Orders: ______________________________________________ ICD Codes ______________________ ____________________________________________________ __________________ ______________________ ____________________________________________________ _____________ _____ ______________________ Physician’s signature ______________________________________________ Date ____________________________
NATALIA MARTÍN CRUZ JUAN HERNANGÓMEZ BARAHONA JUAN MANUEL DE LA FUENTE SABATÉ El ámbito institucional en el que se circunscribe la regulación delos medicamentos en España y los cambios que en él se han producidohan influido necesariamente en el proceso de autorización de nuevosmentos genéricos y precios de referenciaen 1996. Los resultados de estas actuacio-rios creados para
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