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Uncertainty estimation in spot intensity ratio in microarray chip and its role in Evaluation of dose selection markers in radiation oncology: identifying differentially expressed genes What should we look for and how much do new markers improve outcomes? Contribution of alternative splicing isoforms in gene expression values Identification of immunologic biomarkers for prognosis in human breast cancer Translational profiling in childhood acute lymphoblastic leukemia: Evaluating dynamic prognostic indicators for patients’ perceived time of No evidence for glucocorticoid regulation on mRNA translation treatment failure: Application of joint modelling Detection of influential points in drug responses: Pearls and pitfalls in developing imaging biomarkers in oncology clinical trials Standardising reclassification tables for public health modelling de Uña-Álvarez Definition, theoretical properties and practical implementation of adjusted p- Biomarker based phase II trial designs for initial marker validation values for SGoF-type multitesting methods The gain in precision of estimating long-term effets using additional short-term Genetic mapping of blood pressure under salt and medication sensitivity in inbred rat line A combined nonparametric regression and classification model for subgroup Identifying high dimensional statistically significant synergistic interactions in dose-response Effective sample size in a conditionally independent hierarchical model Modelling weight loss success of obese children using a LASSO approach applied for a Bayesian dose finding study with multiple subgroups Using „K-means clustering on latent variables“ for identifying clinically Sample size determinations when planning for establishing indirect On the consistency of principal component scores in high-dimensional data Optimization of a randomized multi-arm phase I-II trial design to evaluate the A multivariate multilevel gaussian model with a mixed effects structure in the safety and immunogenicity of different HIV vaccine strategies Practical use of modified continual reassessment method with prior distribution Diffuse regularization for regression models with highly correlated covariates weighted by effective sample size for a phase I dose-finding study in a new region Interval search: Simultaneous tuning of multiple parameters for high- dimensional penalized regression and classification Phase II trial design with Bayesian response adaptive randomization using longitudinal patient outcomes Making a choice of classification function for class prediction model in gene expression data Investigating adaptive design approaches for bioequivalence trials in early clinical phases Model building strategies in case-control Omics studies with many zero-inflated predictors Spline based analysis and planning of dose-finding studies with active control Classifications of microarrays by new combined discriminant method based on Reducing sample sizes in phase II trials based on exact binomial tests by tinke- dissimilarities build on cumulative distribution function Modeling of p53 protein biosignature as endogenous cell stress sensor: Design of small clinical trial with repeated negative binomial distributed out- A cross sectional biomarker study after a chemical explosion come: A case study of pre-post intervention trial Investigating the association between the acoustic parameters of an inhalation Bias in estimated treatment effect associated with early stopping rules in clinical and the peak inspiratory flow rate of inhalation through a common Dry Powder Nikolakopoulos Sequential designs for small samples: Evaluation and recommendations Validation of a surrogate endpoint by using the meta-analytic approach when the Flexible sequential designs for multi-arm clinical trials Interim decision making strategies in adaptive designs for subpopulation selec- Exploring bias associated with low sample sizes in biomarkers that require a binary decision Some considerations on use of two-phase three-stage adaptive designs Surrogate endpoint validation for count data with application in drug development for Multiple Sclerosis Testing composite and mortality endpoints in group sequential tests A systematic review of the ECG effects of moxifloxacin in thorough QT trials A Bayesian supervised/unsupervised classification method for computer- aided diagnosis Cut-point identification in biomarkers for a censored failure time outcome Latent class models for medical diagnostic tests in multicenter trials The effect of missing data in prediction of survival using short term outcome in discharge Development of a mathematical model to predict hepatic fibrosis in chronic HCV patients based on non-invasive blood markers; data mining analysis Factor analysis of risk variables associated with NT-proBNP and SDMA in healthy Estimating sensitivity and specificity and respective confidence limits of diagnostic tests for clustered binary data Assessment of Bayesian meta-analytical techniques to evaluate surrogate end-points Parametric bootstrap for goodness-of-fit testing relative to the random-effects distribution in mixed models Confidence limits for prevalence of disease adjusted for estimated sensitivity and Simulation methods for design and analysis of disease registries Dental CT scanners and physical quality parameters Some practical issues in designing diagnostic RCTs Mortality associated with adding stereotactic radiosurgery to whole brain Simultaneous confidence intervals for the Area Under the ROC Curve (AUC), radiotherapy in brain metastases patients with lung cancer history; sensitivity and specificity in diagnostic studies conventional logistic and instrumental variables approach Multiclass classification: A comparison of modelling tools and classification Treatment of missing data in crossover randomised controlled trial (RCT): Ap- plication to TOMADO trial of oral Mandibular Advancement Devices (MAD) for Methods for exploring treatment effect heterogeneity in subgroup analysis: Obstructive Sleep Apnoea-Hypopnoea (OSAH) Alternative weighting strategies when planning a multi-level cluster Consistency-adjusted alpha allocation methods for composite endpoints randomized clinical trial with highly variable cluster and patient panel sizes A randomized control trial for the treatment of acute asthma exacerbations in The CIHR Canadian HIV Trials Network (CTN) International Fellowship Program: A model for mentoring young researchers in limited resource settings children: Challenges and opportunities in the paediatric emergency context A Dose-finding Approach Based on Cohort Partitioning for Combination of Two Agents in Phase I Trials in Oncology Omitting an individual time varying binary frailty in Cox´s model for analyzing clinical trials: Consequences on the estimated treatment effect Adaptive Bayesian design of age-dependence dose-response relationship Sample size requirements for pilot randomised controlled trials with binary Fully Bayesian hierarchical modelling in two stages Are Bayesian methods useful for a frequentist? The case of survival analysis Sample size requirements for pilot randomised controlled trials with continuous outcomes: A simulation study A Bayesian Monte-Carlo Markov Chains approach (MCMC) to predict the long-term antibody persistence after Japanese encephalitis vaccination Misconceptions about the three-arm non-inferiority design including a placebo for inference of difference in means or proportions Justification of a prospective meta-analysis approach in therapeutic evaluation BayMeth: An empirical Bayes approach for improved DNA methylation Importance of biostatistics in measurement uncertainty of clinical biochemistry: An application of “Use of the External Quality Control Data” approach quantification from affinity capture sequencing data A study on sample size determination of clinical trials using power prior Design and analysis of three-arm non-inferiority trial with a fixed margin for hazard ratio Using a Bayesian approach with reverse philosophy to design clinical trials Multivariate meta-analysis for multiple outcomes of QOL measurement: Estimation of treatment effect using interval-censored measurement at Corticosteroid and antiviral therapy for Bell’s Palsy: A network meta-analysis Non-compliance and missing data: Using data collected after non-compliance to An individual patient data network meta-analysis of time-to-event data using a one-stage poisson approach Comparison of methods to handle missing data in a multi-item questionnaire Novel presentational standards for reporting network meta-analysis Functional linear regression model for the analysis of daily patient self-rated The impact of control group risk in the relative effectiveness of interventions estimated in network meta-regression scores of the pain in a 6 months observational study Effects after media reports on adolescent suicide: A 10-year time series analysis Evaluation of inconsistency in networks of interventions Decline in the number of patients without antiretroviral therapy among Handling multi-armed trials in frequentist network meta-analysis Characterizing the flow of evidence in a mixed treatment comparison A missing data sensitivity analysis of the phase III study PATENT-1 in Hierarchical frailty model for familial testicular cancer Multiple imputation for missing data from an Intensive Care Unit (ICU) Comparing Multilevel Analysis with Longitudinal IRT modelling in estimating register – problems and consequences for results development over time in three likert-item questionnaires Factors influencing increased left ventricular mass in children and teenagers Trajectories of kidney function decline: Application of the latent class linear with or without family history of premature myocardial infarction mixed model and comparison with standard linear mixed model Clinical progression of high-grade cervical lesions: Estimating the time to precli- Handling missing not at random explanatory variables in repeated nical cervical cancer from doubly censored national registry data Collaborative targeted maximum likelihood estimation for variable importance Bayesian hierarchical modelling of longitudinal glaucomatous visual fields Multistate models in survival analysis of hip replacement in Slovak Impact of missing data on estimates of prevalence of poor outcome after stroke: Serum vitamin A levels and the risk of all-cause and cardiovascular mortality Sensitivity analysis for bed-sharing risk in Sudden infant death syndrome A multi-level multi-process piecewise-linear hazard model for adjusting selection bias: Applications to modeling duration in power Multiple imputation in the presence of non-normal data A simulation study based on empirical clinical data confirms the dangers of the Assessing situations of attenuation bias of estimates of the logistic regression model in the presence of unobserved heterogeneity: A simulation study wide-spread use of composite endpoints in chronic myeloid leukaemia trials Vertical modeling: Analysis of competing risks data with a cured proportion Modelling innovative moments in clinical psychotherapy Multistate models: A common structure for survival models to deal with Weighted discrimininant function for longitudinal data with application to pre-dicting pre-eclampsia from longitudinal hemoglobin and hematocrit profiles Optimal model selection in principal stratification for causal inference Imputing missing data in a pre-post observational study: A comparison The obesity paradox – differential effects of abdominal and general obesity on Using biological sample data to refine latent class growth analysis of repeated ordinal response measures of smoking behaviour A choice of approach for the detection of depression and anxiety among stroke Sample size for a non-inferiority clinical trial with survival data under the Wei-bull distribution and competing risks patients: Do latent class models agree with the commonly used cut off points of the Hospital and Anxiety Depression Scale (HADS)? Challenges of risk prediction in the presence of competing events: Application to transplantation data On the joint use of propensity and prognostic scores in estimation of the average treatment effect on the treated: A simulation study The SIMEX method for correcting the bias in a survival cure model with mismeasured covariates Colliders’ related bias in Propensity Score Estimators Empirical-likelihood-based estimator of multiple robustness for the average Charles-Nelson Analysing recurrent events stopped by several types of terminal events: Strengthening Mendelian randomization through utilizing multiple Semi-parametric methods for multi-state survival models in randomized trials independent paired combinations of genetic variants to evaluate Inverse probability of censoring weighted U-statistics for Quality-Adjusted Survival adjusting for covariate-dependent censoring Comparing inverse probability weighting and G-computation in a longitudinal Pseudo-values for a binary time-dependent covariate in survival analysis Extension of a landmarking model using a fractional polynomial function for Mendelian randomization using summarized data Marginal structural models for estimating the impact of HIV-1 subtype on virolo- Bayesian disease mapping of suicide in the Korean elderly gical and immunological response to HIV treatment in Sweden Finding the optimal prediction time using a dynamic prediction by landmarking Summarising time to event data: A novel estimator of the mean residual function Reporting of censures in survival studies A variance estimator of the cause-specific cumulative incidence function that can be used with standard software Application of cox regression analysis on the case of violation of proportional hazards assumption Methods of tied events handling in Cox proportional hazard model Statistical analysis of determinants of non-adherence to antiretroviral Analysis of censored duration intervals overlapping a fixed time point where treatment and its effect on immunological recovery: A case study at Hawassa censoring and survival times are correlated Individual estimates of disease risks from data on polygenic susceptibility: Communicating time-dependent effects of adjuvant therapies for early stage breast cancer using risk-difference curves Asymptotic results for non-Markov empirical transition probabilities in the Life expectancy after HIV diagnosis based on counseling center for behavioral Construction and validation of prognosis models for cancer survival accounting Survival and perinatal health of fetuses and newborns after pandemic H1N1 Flexible simulation of competing risks data following prespecified Estimation of relative survival of HIV/AIDS patients on antiretroviral therapy in Optimal scheduling of post therapeutic visits of patients treated for cancer for A comparison between the relative and the new net survival analyses Use of serotonin antagonists and QTc prolongation: A retrospective cohort study Non-inferiority using shared fragility models. A randomized trial to evaluate using a electronic medical record database treatment for severe neutropenia in leukemia patients Antimicrobial use in hospital and primary care in Portugal Mainland A covariate adjusted Mann-Whitney test for comparing two Sojourn times under right censoring INN mandatory prescription in Portugal mainland Impact of health policy intervention of new profit margins for wholesale compa-nies and pharmacies The determinant of birth interval in rural Ethiopia Mortality and morbidity after mild head injury hospital admission: Use of routinely collected data for identification of control groups and long-term follow- Methods to assess growth in a systematic review of data from registries in a rare Additive interaction between continuous risk factors, using a logistic Intestinal parasites amongst pre-school aged children in the Democratic Republic of Congo: A multilevel analysis Screening for data clustering in multicenter studies: The variance partitioning A statistical model for the social clustering of subclinical infection among day care groups – an application to Streptococcus pneumoniae colonisation coefficient and residual intraclass correlation Verifying the adequacy of a sample for testing interrater agreement Flexible parametric adjustment method for correcting the impacts of exposure detection limits in regression Growth curves related with height and weight of 0-5 aged Turkish children A framework to interpret external validition studies of prediction models On the interpretation of the estimated association between a composite score Recommended versions of the McNemar test for paired binomial probabilities comprising of multiple binary exposures on continuous outcomes* Testing of gender differences on sib-sib correlations for binary traits: Likelihood based inference with application to arterial blood pressures data Modelling the effects of antimicrobial and antiseptic treatment on carriage levels of MRSA A stepwise variable selection for a Cox proportional hazards cure model Confidence intervals and sample size calculations for sensitivity and specificity Statistical issues arising when the interval between initiation of exposure and death is more than half a century Characterizing the ideal Renal Replacement Therapy: Statistical lessons out of current dialysis practice Predicting the degree of inconsistency among studies in a meta-analysis A novel use of circular statistics to investigate explanatory factors surrounding A new class of additive frailty models with bivariate current status data emergent (unplanned) C-section deliveries Categorisation of continuous covariates in Cox regression models: CONSORT ClinPharm – interim results of a new working group for reporting A closer look at the apparent obesity and mortality “Paradox” Modelling the association between seasonal series: A simulations study Estimation of half-life periods in nonlinear data with fractional polynomials A framework for individual participant data meta-analysis in the presence of Repeated measures design analysed with ANOVA tools in MS-Excel Confidence intervals for odds ratio and relative risk can be improved by the Impact of vitamin D on insulin resistance in type ÐÐ diabetic patients: Sample size determination for cost-effectiveness trials Assessment of the case-chaos analysis as an alternative to the case-control design A sample size formula for confirming PFS and OS in cancer clinical trials A randomised multicenter study of intensive versus standard treatment of pati- Schizophrenia susceptibility and age of diagnosis - a frailty approach A mixture model for the analysis of data derived from record linkage Comparison of the clinical association of current classification schemes for CVID Population- based Metabolic Syndrome Risk Score and its determinants: Designing a study for shift analysis: Applications to acute stroke therapy trials Prediction of being a risk family for colorectal cancer Meta-analysis of time-to-event outcomes from randomized trials using Using propensity scores subclassification for a complex sampling design to restricted mean survival time: Application to individual participant data evaluate the effect of depression on self-reported suicidal ideation The unique difficulties of rare disease patients to access health and social care in Modeling the risk of Borrelia infection after a tick bite - a Bayesian approach Europe and the role of early diagnosis: The case of Prader-Willi Syndrome (PWS) Validation of prediction models based on penalized regression with multiply Prediction of hemoglobin level in blood donors using longitudinal data: Trial designs and methodological aspects of clinical research in Indian systems of Bayesian machine learning approaches for longitudinal latent class modelling to define wheezing phenotype to elucidate genetic and environmental Development and validation of a model to predict liver disease diagnosis in primary care using accelerated failure time models Causes of death and risk of heart related mortality in cancer survivors Developing prognostic models utilising clinical trials data and the baseline compared to the general population, a large population based study Childhood acute lymphoid leukaemia in relation to infections in the community Graphical monitoring of longitudinal clinical trial data Bayesian analysis of pooled dihyroartemisinin concentration data from severe malaria patients and selection of key clinical covariates Evaluation of tests for equality of intra subject variability in bioequivalence studies Sample size requirements for developing a reliable risk prediction model for clus-tered data with a binary outcome: A simulation study Regression models as a tool in medical research - lessons learned from writing a book Reporting of prognostic studies of tumour markers: Do guidelines help? SEchart: An R-function for graphical display of state and event histories The role of Akaike´s information criterion in medical, time related, nested regres-sion models comparison Using time-to-event designs for clinical trials in epilepsy: What about patient safety? Morphological clustering of cancer cell images Optimal sample proportion for a two-treatment clinical trial in presence of surrogate endpoints Non-inferiority using shared fragility models. A randomized trial to evaluate treatment for severe neutropenia in leukemia patients (9(5<<($5:(,19(67025(7+$1ੂ%,//,21,15 ' ZZZPHUFNVHURQRFRP

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MEDIA RELEASE Kavita Gadkari joins Grey Mumbai as Vice President, Planning Singapore, 10 December 2010 – In a year that has seen a constant stream of great talent joining Grey Group, Kavita Gadkari’s appointment as Vice President, Planning will further strengthen the robust planning function at the Mumbai office. Kavita joins Grey from Stellar Search in Dubai where she singl

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