Microsoft word - dermatomycoses--fact sheet #15.doc

[Ringworm (Dermatophytosis, Tinea, Trichophytosis, Microsporosis,
Jock Itch, Athlete's Foot)]
SPECIES: Dogs, cats, rodents, domestic animals
AGENT: Organisms are subclassified into: 1. Geophilic - inhabit soil 2. Zoophilic -
parasitic on animals 3. Anthropophilic - Primarily infects humans. All can produce
disease in humans. Grouped in three genera 1. Microsporum 2. Trichophyton 3.
RESERVOIR AND INCIDENCE: Fungal spores remain viable for long periods on
carrier animals and fomites. Exposure to reservoir hosts harboring different
dermatophytes determines the type and incidence of infection in humans. Microsporum
canis can be carried by up to 89% of nonsymptomatic cats. Up to 50% of people
exposed to infected cats, both symptomatic and asymptomatic, have acquired
Pets may also acquire disease from humans. **T. mentagrophytes is most
commonly transmitted to man from rodents, M. canis from dogs and cats, and T.
verrucosum from cattle and horses.
TRANSMISSION: Direct or indirect contact with asymptomatic animals or with skin
lesions of infected animals Contaminated bedding Equipment Fungi in air, dust, or on
surfaces of room (spores persist on contaminated surfaces)
DISEASE IN ANIMALS: Disease in rodents is often asymptomatic and not recognized
until people are affected. Infected cats are often asymptomatic. Dogs often show classic
skin lesions. Varying severity of dermatitis occurs with local loss of hair. Deeper
invasion produces a mild inflammatory reaction which increases in severity with the
development of hypersensitivity.
DISEASE IN MAN: Often mild, self limiting; scaling, redness, and occasionally
vesicles or fissures. Thickening & discoloring of nails. May show circular lesions which
clear in the center forming a ring affect. Fungal infections in man are categorized as to
the location on the body: 1. Tinea capitis - Scalp & hair 2. Tinea corporis - Body
(extremities, arm and hand, are most often affected in infections acquired from lab
animals.) 3. Tinea pedis - foot 4. Tinea unguium - Nails
DIAGNOSIS: KOH mount of skin scrapings, Fungal culture
TREATMENT: Macerated (moist softening and fissuring) stage- aluminum subacetate
("Domeboro") solution soaks with potassium permanganate for secondary infections.
Broad spectrum antifungal creams and solutions containing imidazoles or ciclopirox)
instead of tolnaftate and haloprogin help to combat diphtheroids and other gram-positive
organisms present at this stage and alone may be adequate therapy. Dry and scaly stage-
several topical creams, liquids, or lotions are recommended (miconazole, clotrimazole,
ketoconazole, econazole, sulconazole, oxiconazole, ciclopirox or naftifine.
Betamethasone dipropionate with clotrimazole is recommended for acutely inflamed tinea lesions. For severe cutaneous infections, griseofulvin or ketoconazole is recommended. PREVENTION/CONTROL: Screen newly received animals. Routine sanitization of
contaminated environment, equipment, and caging. Gloves, protective clothing, wash
hands after exposure.
(This publication is courtesy of the University Research Compliance Office, Kansas State University.)



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Microsoft word - doxycycline vascular type of ehlers.docx

Doxycycline ameliorates the susceptibility to aortic lesions in a mouse model for the vascular type of Ehlers-Danlos syndrome Wilfried Briest, Timothy K. Cooper, Hyun-Jin Tae, Melissa Krawczyk, Nazli B. McDonnell, Mark I. Talan Laboratory of Cardiovascular Sciences (W.B., H.J.T., M.K., M.I.T.) and; Laboratory of Clinical Investigation (N.B.M.), National Institute on Aging, Baltimore, MD; De

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