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Vitamin C and Fertility
• Vitamin C is also an antioxidant, and studies show The results of this preliminary study suggest that that vitamin C enhances sperm quality, protecting vitamin C improves hormone levels and increases sperm and the DNA within it from damage. Some fertility in some women with luteal phase defect. (3) research has indicated that certain types of DNA damage in the sperm can make it difficult to conceive • Vitamin C may benefit fertility in its ability to promote in the first place, or it can cause an increased risk of collagen synthesis, its role in hormone production and miscarriage if conception does take place. If DNA is its ability protect cells from free radicals. (4) damaged, there may be a chromosomal problem in the baby, should the pregnancy proceed. Whether • As in males vitamin C has been suggested or not DNA damage does have these effects has not as a regulator of female fertility. Vitamin C been conclusively proven, but it’s worth taking vitamin supplementation enhances the ovulation-inducing C and the other antioxidants as a precautionary effects of clomiphene by an apparently local ovarian Vitamin C also appears to keep the sperm from • Large quantities of vitamin C are utilized during clumping together, making them more motile.
One study has shown that women taking the drug • conception and are necessary to maintain clomiphene to stimulate ovulation will have a better the integrity of fetal membranes. Dietary chance of ovulating if vitamin C is taken alongside supplementation during pregnancy may reduce the the drug. Clomiphene does not always work in every frequency of birth defects and a daily supplement woman, but the chances are often increased when of at least 500 mg of vitamin C starting as early in pregnancy as possible has been suggested for • A moderate amount of supplemental vitamin C improves hormone levels and increases fertility in • The Vitamin C Connection reports that Dr. Ingarshi women with luteal phase defect, according to a new treated forty-two women with differing ovarian study published in Fertility and Sterility (2003;80:459– problems. Clomiphene citrate, a popular fertility drug of the time, had failed to help these women who produced no fertile eggs (anovulation) or had no • One hundred fifty women with luteal phase menstrual period (amenorrheic). Of these forty-two defect seeking medical attention for infertility were women, 40% began to ovulate and 21% later became enrolled in the current study. Levels of estrogen and pregnant. Dr. Igarashi observes that “the possible progesterone were monitored for three menstrual site of action of ascorbic acid seems to be at the cycles. The participants were randomly assigned to receive 750 mg of vitamin C per day or no treatment beginning at the onset of the third cycle of the study. • These findings lead to the conclusion that Sesamum During the third cycle, progesterone levels increased indicum + Vitamin C promote fertility due to both their significantly in women receiving vitamin C but did not testosterone-increasing effects and their antioxidant change in women receiving no treatment. Estrogen levels also increased in the treatment group but • A low intake of antioxidant nutrients was associated not the untreated group. Moreover, there was a with a poor semen quality in this case-control study of significantly higher pregnancy rate in the vitamin Spanish men attending infertility clinics. (10) C group than in the untreated group: 25% of the women receiving vitamin C became pregnant within six months of starting treatment, while only 11% of untreated women became pregnant in the same time References:
1. Dr. Marilyn Glenville
7. “Ascorbic Acid and Fertility”, Luck, Martin R., et al, Biology of Reproduction, 1995;52:262-266.
8. Dr. Masao Igarashi Department of Obstetrics and Gynecology, School of Medicine, Gunma University, 4. “Ascorbic Acid and Fertility”, Luck, Martin R., et al, Biology of Reproduction, 1995;52:262-266.
9. Efficacy of vitamin C and ethanolic extract of 5. “Ascorbic Acid and Fertility”, Luck, Martin R., et al, Biology of Reproduction, 1995;52:262-266.
6. “Ascorbic Acid and Fertility”, Luck, Martin R., et al, Biology of Reproduction, 1995;52:262-266.



CHAPTER 15 Nervous System Drugs Nonphenothiazine Half-life: Onset: Duration: IM: 15–30 min IM: 30–45 min IM: 4–8 hIM: Decanoate IM: Decanoate IM: Decanoate behavioral problems in children, short-term treatment of hyperactivity in children; treatment of infantile autism, Huntington’s chorea, nausea/vomiting associated with cancer therapy. Pregnancy Pharmacokinetic: PB: 8

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