September MIMS Monthly Medicine Update NEW PRODUCTS
Priligy (dapoxetine hydrochloride)
Zaltrap (aflibercept (rch)) is a
Erivedge (vismodegib) is a low
severe chronic neutropenia (SCN); and in
endothelial growth factor (VEGF) receptor
(1 and 2) extracellular domains fused to
HIV therapy. Zarzio is contraindicated in
ejaculatory latency time (IELT) of less than
patients with known hypersensitivity to E
(SMO) leads to the activation and nuclear
coli derived products. Zarzio is available
localisation of GLI transcription factors
ejaculation with minimal sexual stimulation
GyMiso is contraindicated in the following
before, on, or shortly after penetration
microgram per 0.5 mL prefilled syringe.
situations: if there is a contraindication
expression system. Zaltrap in combination
SAFETY RELATED CHANGES
transduction. Erivedge is indicated for the
chemotherapy is indicated in adults with
Avapro, Karvea (irbesartan) and
treatment of adult patients with metastatic
treatment with anticoagulants; uncertainty
a poor control over ejaculation. Priligy
Avapro HCT, Karvezide (irbesartan/
is contraindicated in all of the following
hydrochlorothiazide) are now
conditions: significant pathological cardiac
contraindicated with aliskiren containing
surgery and/or radiation therapy are not
mifepristone. GyMiso is available as a 200
medicines in patients with diabetes or with
appropriate. Erivedge is contraindicated
failure), conduction abnormality (2nd, 3rd
hyperosmotic properties of Zaltrap. Zaltrap
moderate to severe renal impairment.
Jakavi (ruxolitinib phosphate) is an
degree A-V block or sick sinus syndrome)
is available in vials of 100 mg/4 mL and
Efudix (fluorouracil) is now
inhibitor of the Janus Associated Kinases
Zarzio (filgrastim (rbe)) is a
treatment and for 7 months after the last
potency. JAKs mediate the signalling of a
disease; concomitant MAOIs, thioridazine,
dose. It is also contraindicated in nursing
Stimulating Factor (rmetHuG-CSF) derived
Normison (temazepam) is now
mothers during the course of treatment and
drugs/ herbs (eg L-tryptophan, triptans,
from E. coli. Zarzio is indicated in the
for 7 months after the last dose because of
and immune function. Ruxolitinib inhibits
tramadol, linezolid, lithium, St John’s
reduction of neutropenia duration, clinical
the potential to cause serious development
JAK-STAT signalling and cell proliferation
wort) (including less than 14 days before
defects in breastfed infants and children.
starting, less than 7 days after ceasing
depression, due to a risk of suicide.
Erivedge is available as a 150 mg tablet in
Xarelto (rivaroxaban) is now
is indicated for the treatment of disease
inhibitors eg ketoconazole, itraconazole,
atazanavir, nelfinavir, ritonavir, saquinavir,
GyMiso (misoprostol) is a synthetic
mobilisation of peripheral blood progenitor
telithromycin, nefazodone; and in moderate
analogue of prostaglandin E1. In the event
patients with primary myelofibrosis, post-
to severe hepatic impairment. Priligy is
This list is a summary of only some of the
available as a 30 mg tablet is packs of 3’s
changes that have occurred over the last
essential thrombocythemia myelofibrosis.
donors (allergenic); infection incidence
month. Before prescribing, always refer to
Jakavi is available as 5 mg, 15 mg and 20
Widespread accumulation of [3H]testosterone in the spinal cord of a wild bird with an elaborate courtship display J. DOUGLAS SCHULTZ AND BARNEY A. SCHLINGER*Department of Physiological Science and Laboratory of Neuroendocrinology, Brain Research Institute, University of California, Los Angeles, CA 90095-1527 Communicated by Peter Marler, University of California, Davis, CA, June 22, 1999 (rece
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